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| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | Linear approach for solving a piecewise linear vendor selection problem of quantity discounts using lexicographic method显示文摘 | Arunkumar N Karunamoorthy L Anand S Ramesh B T | 2006 | International Journal of Advanced Manufacturing Technology2006，28，11： | 1 |
| 3 | Chemical and structural instability of the chemically delithiated(1-z) Li O2 · (z) Li O2 (0≤y≤1 and 0≤z≤1) solid solution cathodes显示文摘 | Arunkumar T A Alvarez E Manthiram A | 2008 | J Mater Chem2008，18，2： | 1 |
| 4 | 显示文摘 | Arunkumar T A Manthiram A | 2005 | Electrochimica Acta2005，50，： | 1 |
| 5 | Experimental studies on the superplastic forming of square shaped components and diffusion bonding characteristics of Ti-6AI-4V alloy显示文摘 | RAYUDU R K ARUNKUMAR T BHATTACHARYA S S | 2013 | Transactions of the Indian Institute of Metals2013，66，4： | 1 |
| 6 | Linear approach for solving a piecewise linear vendor selection problem of quantity discounts using lexieographie method显示文摘 | Arunkumar N Karunamoorthy L Anand S and Ramesh B T | 2006 | International Journal of Advanced Manufacturing Technology2006，28，11： | 1 |
| 7 | Effect of water and air flow on concentric tubular solar water desalting system显示文摘 | Arunkumar T Jayaprakash R Ahsan A | 2013 | Applied Energy2013，103，： | 1 |
| 8 | Effect of water and air flow on concentric tubular solarwater desalting system 显示文摘 | T Arunkumar R Jayaprakash Amimul Ahsan | 2013 | Applied Energy2013，103，： | 1 |
| 9 | Proton insertion into oxide cathode during chemical delithiation显示文摘 | Choi J Alvarez E Arunkumar T A | 2006 | Electrochemical and Solid-State Letters2006，9，5： | 1 |
| 10 | Structure and stability of an acidic fibroblast growth factor from Notophthalmus viridescens显示文摘 | ARUNKUMAR A I SRISAILAM S KUMAR T K | 2002 | J Bid Chem2002，277，46： | 1 |
| 11 | Achiral bisi?mine in combination with CoCh: A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol显示文摘 | Arunkumar K Reddy M A Kumar T Sv | 2010 | Beilstein J Org Chern2010，6，： | 1 |
| 12 | Spatial variation of heat flux at the metal mold interface due to mold filling effects in gravity die-casting显示文摘 | ARUNKUMAR S RAO K V S KUMAR T S P | 2008 | International Journal of Heat and Mass Transfer2008，51，： | 1 |
| 13 | Genetic algorithm based heuristics for the mapping problem 显示文摘 | Chockalingham T Arunkumar S | 1994 | Computers & Operations Research1994，22，1： | 1 |
| 14 | 显示文摘 | Arunkumar T A Wu Y Manthiram A | 2007 | Chem Mater2007，19，： | 1 |
| 15 | Genetic algorithm based heuristics for the mapping problem 显示文摘 | Chockalingham T Arunkumar S | 1994 | Computer & Operations Research1994，22，1： | 1 |
| 16 | Genetic search algorithms and their randomized operators 显示文摘 | Arunkumar S Chocklingam T | 1996 | Computers Math1996，25，12： | 1 |
| 17 | Genetic search algorithms and their randomized operators显示文摘 | Arunkumar S Chockalingam T | 1993 | Computers Math Applic1993，25，： | 1 |
| 18 | An improved Bayesian classification data mining method for early warning landslide susceptibility model using GIS显示文摘 | VENKATESAN M ARUNKUMAR T | 2013 | Advances in Intelligent Systems and Computing2013，2，7： | 1 |
| 19 | Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis显示文摘 | Jacovina Andrew T Deora Arunkumar B Ling Qi Broekman M Johan Almeida Dena Greenberg Carojine B Marcus Aaron J Smith Jonathan D Hajjar Katherine A | 2009 | Journal of Clinical Investigation2009，，11： | 1 |
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