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| 1 | Science behind cisplatin-induced nephrotoxicity in humans:A clinical study显示文摘Objective:To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity.Methods:We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolytes,creatinine,blood urea nitrogen(BUN) and urine potassium,sodium and pH levels before and after the cisplatin chemotherapy.All the patients had cancer and were treated with 40-50 mg/day cisplatin.Renal injury was assessed by measuring serum electrolytes,creatinine,BUN levels and urine potassium,sodium and pH levels. Results:The five cycles of cisplatin based chemotherapy resulted in hypomagnesia(P=0.029), hypocalcaemia(P=0.001~*),hypophosphatemia(P=0.003*),hypokalemia(P=0.001~*)and increased serum creatinine(P=0.001~*)and BUN(P=0.292~*)levels.In urine analysis,decrease in potassium(P=0.024~*)was found,except potassium there was no significant changes in sodium and urine pH. Conclusions:The present study demonstrates that,acute nephrotoxicity was observed in patients with different types of cancers undergoing cisplatin based chemotherapy due to electrolyte disturbances,when no corrective measures were initiated. | Arunkumar PA Viswanatha GL Radheshyam N Mukund H Belliyappa MS | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 3 |
| 2 | Drug-induced hypersensitivity syndrome with human herpesvirus-6 reactivation 显示文摘 | Riyaz N Sarita S Arunkumar G | 2012 | Indian J Dermatol Venereol Leprol2012，78，2： | 1 |
| 3 | Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3 显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
| 4 | Linear approach for solving a piecewise linear vendor selection problem of quantity discounts using lexicographic method显示文摘 | Arunkumar N Karunamoorthy L Anand S Ramesh B T | 2006 | International Journal of Advanced Manufacturing Technology2006，28，11： | 1 |
| 5 | Linear approach for solving a piecewise linear vendor selection problem of quantity discounts using lexieographie method显示文摘 | Arunkumar N Karunamoorthy L Anand S and Ramesh B T | 2006 | International Journal of Advanced Manufacturing Technology2006，28，11： | 1 |
| 6 | Induction of apoptosis and histone hyperacetylation by diallyl disulfide in prostate cancer cell line PC-3显示文摘 | Arunkumar A Vijayababu M R Gunadarini N | 2007 | Cancer Lett2007，251，1： | 1 |
| 7 | Garlic compound, diallyl disulfide induces cell cycle ar-rest in prostate cancer cell line PC-3显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Bio-chem2006，288，12： | 1 |
| 8 | Garlic compound,diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3显示文摘 | Arunkumar A Vijayababu M R Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
| 9 | The antibac- terial compound sulphougiyeerolipid 1-opalmitoyl-3-o (6- sulpho-c:-oquinovopyranosyl)-glycerol from Sargassum wig- htii Greville ( Phaeophyceae ) 显示文摘 | Arunkumar K Selvapalam N Rengasamy R | 2005 | Bot Mar2005，48，1： | 1 |
| 10 | Induction of apoptosis and histone hyperacetylation by diallyl disulfide in prostate cancer cell line PC-3显示文摘 | Arunkumar A Vijayababu MR Gunadharini N | 2007 | Cancer Lett2007，251，1： | 1 |
| 11 | Induction of apoptosis and histone hyperacetylation by diallyl disulfide in prostate cancer cell line PC-3 显示文摘 | Arunkumar A Vijayabatu M R Gunadharini N | 2007 | Cancer Letters2007，251，1： | 1 |
| 12 | Oomparison of dexmedetomidine and clonidine as an adjuvant to ropivacaine for epidural anesthesia in lower abdominal and lower limb surgeries显示文摘 | Arunkumar S Kumar VRH Krishnaveni N | 2015 | Saudi journal of anaesthesia2015，9，4： | 1 |
| 13 | Experimental design to predict process variables in the preparation of cellulose based sustained release microspheres system loaded with prednisolone-cyclodextrin complex显示文摘 | MOHANRAJ P JASMINA K ARUNKUMAR N | 2011 | Korean Journal Chemical Engineering2011，28，10： | 1 |
| 14 | Polyvalent Antigens Stabilize B Cell Antigen Receptor Surface Signaling Microdomains 显示文摘 | Thyagarajan R Arunkumar N Song W | 2003 | J Immunol2003，170，12： | 1 |
| 15 | Nanosuspension technology and its applications in drug delivery显示文摘 | Arunkumar N Deecaraman M Rani C | 2009 | Asian JPharm2009，3，3： | 1 |
| 16 | Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC - 3显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
| 17 | Multi - criteria supplier evaluation and selection using fuzzy AHP ( alpha cut analysis) : A case study 显示文摘 | ARUNKUMAR N KARUNAMOORTHY L MUTHUKUMAR S | 2011 | International Journal of Industrial and Systems Engineering2011，8，4： | 1 |
| 18 | Garlic compound,diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
| 19 | Drug-induced hypersensitiv- ity syndrome with human herpesvirus -6 reactivation显示文摘 | Riyaz N Sarita S Arunkumar G | 2012 | Indian J Dermatol Venereol Leprol2012，78，2： | 1 |
| 20 | Prevalence of measles, mumps, rubella, and varicella susceptibility among health science students in a University in India 显示文摘 | Arunkumar G Vandana KE Sathiakumar N | 2013 | Am J Ind Med2013，56，1： | 1 |
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