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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | A Prospective Randomized Comparison of Bilateral Subtotal Thymidectomy Versus Unilateral Total and Contralateral Subtotal Thyroidectomy for Graves,diseaso显示文摘 | Hsei KC Sheen SM | 2005 | World J Surg2005，29，2： | 1 |
| 3 | Overexpression of multiple drug resistance genes in endothelial cells from patients withrefractory epilepsy显示文摘 | Dombrowski SM Desai SY Marroni M | 2001 | Epilepsia2001，42，12： | 1 |
| 4 | Preconditioning and postcon-ditioning:the essential role of the mitochondrial permeability transition pore显示文摘 | Lim SY Davidson SM Hausenloy DJ | 2007 | Cardiovasc Res2007，75，3： | 1 |
| 5 | Design, methodology and baseline data of a school-based cohort study in central China: the Anyang Childhood Eye Study 显示文摘 | Li SM Liu LR Li SY | 2013 | Ophthalmic Epidemiol2013，20，6： | 1 |
| 6 | Effects of activation of Caspase-3in cerebral ischemic reperfusion injury显示文摘 | Yang Y Zhang SM Fan SY | 2004 | Zhonghua Yi Xue Za Zhi2004，84，： | 1 |
| 7 | Neutralization epitopes on the antigenic domain U of the Orientia tsutsugamushi 56-kDa protein revealed by monoclonal antibodies显示文摘 | Seong SY Kim MK Lee SM | 2000 | Vaccine2000，19，1： | 1 |
| 8 | Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enbanced expression of FasL 显示文摘 | Syed V Ho SM | 2003 | Oncogene2003，22，： | 1 |
| 9 | Regulation of ROS-independent ERK signaling rescues replicative cellular senescence in ex vivo expanded human c-kit-positive cardiac progenitor cells 显示文摘 | Choi SH Jung SY Yoo SM | 2013 | Int J Cardiol2013，169，1： | 1 |
| 10 | lmpact of extravascular lung water index on outeomes of severe sepsis patients in a medical intensive care unit显示文摘 | Chung FT Lin SM Lin SY | 2008 | Respir Med2008，102，7： | 1 |
| 11 | Cerebrospinal Fluid Markers of Alzheimer' s Disease Pathology and Microglial Activation are Associated with Ahered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer' s Disease显示文摘 | Melah KE Lu SY Hoscheidt SM | 2015 | J Alzheirners Dis2015，50，3： | 1 |
| 12 | Experimental Study on Oxygen-enriched Combustion of Biomass Microfuel显示文摘 | Luo SY Xiao B Hu ZQ Liu SM Guan YW | 2009 | Energy2009，34，11： | 1 |
| 13 | Incidence, clinical features, and prognostic impact of CALR exon 9 mutations in essential thrombocythemia and primary myelofibrosis: an experience of a single tertiary hospital in Korea显示文摘 | Park SH Kim SY Lee SM | 2015 | Ann Lab Med2015，35，2： | 1 |
| 14 | The transgression record of the Gucheng Lake in 9.6 ka B. P.显示文摘THE Gucheng Lake is located in Gaochun County, Jiangsu Province, China (31°14′36'—31°19′28'N, 118°51′34'—118°57′56'E). It lies in the southeast monsoon climate area. To study the pateoclimatic and environmental change of the lake area since Late Ice Age and clarify evolution of the southeast monsoon, a core of 20 m (GS1) was drilled at the center of | Shen, J Wang, SM Liu, SY Zhang, G | 1997 | Chinese Science Bulletin1997，42，17： | 1 |
| 15 | A prospective randomized comparison of bilateral subtotal thyroidectomy versus unilater- al total and contralateral subtotal thyroidectomy for Graves' disease显示文摘 | Chi SY Hsei KC Sheen-Chen SM | 2005 | Word J Surg2005，29，2： | 1 |
| 16 | A multi-center survey of HPV knowledge and attitudes toward HPV vaccination among women,government officials,and medical personnel in China显示文摘 | Zhao FH Tiggelaar SM Hu SY | 2012 | Asian Pac J Cancer Prey2012，13，： | 1 |
| 17 | Impact of combined prophy- lactic unilateral central neck dissection and hemithyroidectomy in patients with papillary thyroid microcarcinoma显示文摘 | Hyun SM Song HY Kim SY | 2012 | Ann Surg On- col2012，19，2： | 1 |
| 18 | hnpact of adequate empirical combination therapy on mortality from bacteremic Pseudomonas aeruginosa pneumonia 显示文摘 | Park SY Park HJ Moon SM | 2012 | BMC Infect Dis2012，12，1： | 1 |
| 19 | Exposure to suicide and suicidal behaviors among Hong Kong adolescents 显示文摘 | Wong Joy PS Stewart SM Ho SY | 2005 | Soe Sci Med2005，61，3： | 1 |
| 20 | The novel adipocytokine vis- fatin exerts direct cardio-protective effects 显示文摘 | Lim SY Davidson SM Paramanathan A J | 2008 | J Cell Med2008，12，4： | 1 |
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