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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020,26,34: | 5 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017,25,9: | 2 |
| 3 | Celiac artery aneurysm em- bolization by coil occlusion 显示文摘 | Syed M Shaikh A Neravetla S | 2005 | Ann Vase Surg2005,19,: | 1 |
| 4 | MRG15 is a novel PALB2-interaeting :ctor involved in homologous recombin:ion 显示文摘 | Sy S M Huen M S Chen J | 2009 | J Biol Chem2009,284,21: | 1 |
| 5 | Polypropylene/polystyrene blends-preliminary studies for compatibilization by aromatic-grafted polypropylene显示文摘 | Syed Mustafa S J Nor Azlan M R Ahmad Fuad M Y | 2001 | J Appl Polym Sci2001,82,: | 1 |
| 6 | New symptomatic vertebral compression fractures within a year following vertebroplasty inosteoporotic women显示文摘 | Syed M Patel N Jan S | 2005 | AJNR2005,26,: | 1 |
| 7 | Treatment of oily water using hydrophobic nano-silica 显示文摘 | Syed S Alhazzaa M I Asif M | 2011 | Chemical Engineering Journal2011,167,1: | 1 |
| 8 | A rearranged hydroperoxide from the reduction of artemisinin 显示文摘 | Sy L K Hui S M Cheung K K | 1997 | Tetrahedron1997,53,22: | 1 |
| 9 | Production of polyclonal antiserum against recombinant VP28 protein and its application for the detection of white spot syndrome virus in crustaceans显示文摘 | Yoganandhan K Syed M S Narayanan R B | | 0,,09: | 1 |
| 10 | Anatomic study of a new axial skin flap based on the cutaneous branch of the medial plantar artery显示文摘 | Zhang G M Syed S A Tsai T M | 1995 | Microsurgery1995,16,21: | 1 |
| 11 | Management of button battery stricture in 22-day-old neonate显示文摘 | RABOEI E H SYED S S MAGHRABi M | 2009 | Eur J Pediatr Surg2009,19,: | 1 |
| 12 | Inhibitory effect of Maobushi-Saishin-to on prostaglandin E2 synthesis in C6 rat glioma cells 显示文摘 | Saito SY Kamiyama S Oda M | 2004 | Biol Pharm Bull2004,27,7: | 1 |
| 13 | Production of doubled haploid on- ions(A//ium cepa)and evaluation of their field perfonnanee显示文摘 | Kim S Kil SY Leonard M | 2007 | Hort Environment and Biotechnology2007,48,3: | 1 |
| 14 | Treatment of toenailonychomycosis with 2% butenafine and 5% Melaleuca altemifolia(tea tree ) oil in cream 显示文摘 | SYED T A QURESHI Z A ALI S M | 2002 | Trop Med Int Health2002,4,4: | 1 |
| 15 | Prehypertension-associatedelevation in circulating lysophosphatidlycholines,Lp-PLA2activity,and oxidative stress显示文摘 | Kim M Jung S Kim SY | 2014 | PLoS One2014,9,96: | 1 |
| 16 | c- Mangostin, a xanthone form mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth 显示文摘 | JOHNSON 3 J PETIWALA S M SYED D M | 2012 | Carcinogenesis2012,33,2: | 1 |
| 17 | Squamous cell carcinoma of the thyroid gland: primary or secondary disease 显示文摘 | Syed MI Stewart M Syed S | 2011 | J Laryngol Otol2011,125,: | 1 |
| 18 | A scalable hybrid decision system (HDS) for Roman wordrecognition using ANN wordrecognition 显示文摘 | OMAR N A1-BOERIDI S M SYED AHMAD S P Koh | 2015 | Neural SVM:study case on Malay Comput&Applic2015,26,: | 1 |
| 19 | Intradiskal extravasation with low-volume cement filling in percutaneous vertebroplasty显示文摘 | Syed M Patel N Jan S | 2005 | AJNR2005,26,9: | 1 |
| 20 | Role of the pulsed dye laser in the management of ulcerated capillary haemangiomas 显示文摘 | Lacour M Syed S Linward J | 1996 | Arch Dis Child1996,74,2: | 1 |