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| 1 | Multimodality management of gallbladder cancer can lead to a better outcome:Experience from a tertiary care oncology centre in North India显示文摘BACKGROUND Surgical resection is a treatment of choice for gallbladder cancer(GBC)patients but only 10%of patients have a resectable disease at presentation.Even after surgical resection,overall survival(OS)has been poor due to high rates of recurrence.Combination of surgery and systemic therapy can improve outcomes in this aggressive disease.AIM To summarize our single-center experience with multimodality management of resectable GBC patients.METHODS Data of all patients undergoing surgery for suspected GBC from January 2012 to December 2018 was retrieved from a prospectively maintained electronic database.Information extracted included demographics,operative and perioperative details,histopathology,neoadjuvant/adjuvant therapy,follow-up,and recurrence.To know the factors associated with recurrence and OS,univariate and multivariate analysis was done using log rank test and cox proportional hazard analysis for categorical and continuous variables,respectively.Multivariate analysis was done using multiple regression analysis.RESULTS Of 274 patients with GBC taken up for surgical resection,172(62.7%)were female and the median age was 56 years.On exploration,102 patients were found to have a metastatic or unresectable disease(distant metastasis in 66 and locally unresectable in 34).Of 172 patients who finally underwent surgery,93(54%)underwent wedge resection followed by anatomical segment IVb/V resection in 66(38.4%)and modified extended right hepatectomy in 12(7%)patients.The postoperative mortality at 90 d was 4.6%.During a median follow-up period of 20 mo,71(41.2%)patients developed recurrence.Estimated 1-,3-,and 5-years OS rates were 86.5%,56%,and 43.5%,respectively.Estimated 1-and 3-year disease free survival(DFS)rates were 75%and 49.2%,respectively.On multivariate analysis,inferior OS was seen with pT3/T4 tumor(P=0.0001),perineural invasion(P=0.0096),and R+resection(P=0.0125).However,only pT3/T4 tumors were associated with a poor DFS(P<0.0001).CONCLUSION Multimodality treatment significantly improves the 5-year survival rate of patients with GBC up to 43%.R+resection,higher T stage,and perineural invasion adversely affect the outcome and should be considered for systemic therapy in addition to surgery to optimize the outcomes.Multimodality treatment of GBC has potential to improve the survival of GBC patients. | Shaifali Goel Abhishek Aggarwal Assif Iqbal Vineet Talwar Swarupa Mitra Shivendra Singh | 2021 | World Journal of Gastroenterology2021，27，45： | 5 |
| 2 | Pulmonary and Cardiovascular Complications of Obesity: An Autopsy Study of 76 Obese Subjects显示文摘 | Haque Abida K Gadre Swarupa Taylor Jerrod Haque Sajid A Freeman Daniel Duarte Alex | 2008 | Archives of Pathology & Laboratory Medicine2008，，9： | 2 |
| 3 | Study of cyanide removal from contaminated water using zinc peroxide nanomaterial显示文摘The present study highlights the potential application of zinc peroxide(ZnO_2)nanomaterial as an efficient material for the decontamination of cyanide from contaminated water. A process patent for ZnO_2 synthesis has been granted in United States of America(US Patent number 8,715,612; May 2014),South Africa,Bangladesh,and India. The ZnO_2 nanomaterial was capped with polyvinylpyrrolidone(PVP)to control the particle size. The PVP capped ZnO_2nanomaterial(PVP-ZnO_2)before and after adsorption of cyanide was characterized by scanning electron microscope,transmission electron microscope,X-ray diffractometer,Fourier transform infrared spectroscopy and time of flight-secondary ion mass spectrometry. The remaining concentration of cyanide after adsorption by PVP-ZnO_2 was determined using ion chromatograph. The adsorption of cyanide over PVP-ZnO_2 was also studied as a function of p H,adsorbent dose,time and concentration of cyanide. The maximum removal of cyanide was observed in p H range 5.8–7.8 within 15 min. The adsorption data was fitted to Langmuir and Fruendlich isotherm and it has been observed that data follows both the isotherms and also follows second order kinetics. | Himani Uppal S. Swarupa Tripathy Sneha Chawla Bharti Sharma M.K. Dalai S.P. Singh Sukhvir Singh Nahar Singh | 2017 | Journal of Environmental Sciences2017，29，5： | 2 |
| 4 | Structural and functional a- nalysis of Staphylococcus aureus NADP - dependent IDH and its comparison with bacterial and human NADP- dependent IDH 显示文摘 | Prasad U V Swarupa V Yeswanth S | 2014 | Bioinformation2014，10，2： | 1 |
| 5 | Comparison of the expression patterns of two small gene families of S gene family receptor kinase genes during the defence response in Brassica oleracea and Arabidopsis thaliana显示文摘 | Pastugliaa M Swarupa R Rochera A | 2002 | Gene2002，282，12： | 1 |
| 6 | Chlorination byproducts, their toxicodynamics and removal from drinking water显示文摘 | Krishna Gopal Sushree Swarupa Tripathy Jean Luc Bersillon Shashi Prabha Dubey | 2006 | Journal of Hazardous Materials2006，，1： | 1 |
| 7 | Removal of Fluoride from Drinking Water by Adsorption onto Alumimpregoated Activated Alumina 显示文摘 | Sushree Swarupa Tripathy Jean - Luc Bersillon Krishna Gopal | 2006 | Separation and Purification Technology2006，50，30： | 1 |
| 8 | Removal of fluoride from drinking water by adsorption onto alumimpregnated activated alumina显示文摘 | Bersillon JEAN-LUC | 2006 | Separation and Purification Technology2006，50，3： | 1 |
| 9 | Abatement of fuoride from water using manganese dioxide-coated activated alumina 显示文摘 | Sushree Swarupa Tripathy Ashok M Raichur | 2008 | Journal of Hazardous Materials2008，153，3： | 1 |
| 10 | Chlorination byproducts, their toxicodynamics and removal from drinking water 显示文摘 | GOPAL Krishna TRIPATHY Sushree Swarupa BERSILLON Jean Luc | 2007 | Journal of Hazardous Materials2007，140，12： | 1 |
| 11 | Removal of fluoride from drinking water by adsorption onto alum - impregnated activated alumina 显示文摘 | Sushree Swarupa Tripathy Jean - Luc Bersillon Krishna Gopal | 2006 | Separation and Purification Technology2006，50，31： | 1 |
| 12 | Abatement of fluoride from water using manganese dioxide-coated activated alumina显示文摘 | Sushree Swarupa Tripathy Ashok M. Raichur | 2007 | Journal of Hazardous Materials2007，，3： | 1 |
| 13 | Chlorination byproducts, their toxieodynamics and removal from drinking water 显示文摘 | Krishna Gopal Sushree Swarupa Tripathy Jean Luc Bersillon | 2007 | Journal of Hazardous Materials2007，，10： | 1 |
| 14 | Design of a nonglycosylated outer domain-derived HIV-1 gp120 immunogen that binds to CD4 and induces neutralizing antibodies显示文摘 | Bhattacharyya S Rajan RE Swarupa Y | 2010 | J Biol Chem2010，285，27： | 1 |
| 15 | Chlorination byproducts ,their toxicodynamics and removal from drinking water显示文摘 | Krishna Gopal Sushree Swarupa Tripathy Jean Luc Bersillon etal | 2007 | Journal of Hazardous Materials2007，，10： | 1 |
| 16 | The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat显示文摘 | Somsuta Chakraborty Sami Stalin Nirmalendu Das Somsubhra Thakur Choudhury Swarupa Ghosh Snehasikta Swarnakar | 2012 | Biomaterials2012，，10： | 1 |
| 17 | Removal of fluoride from drinking water by adsorption unto alum-impregnated activated alumina显示文摘 | Sushree Swarupa Tripathy Jean-Luc Bersillon Krishna Go- pal | 2006 | Separation and Purification Technology2006，，50： | 1 |
| 18 | Removal of fluoride from drinking water by adsorption onto alum-impregnated activated alumina显示文摘 | Sushree Swarupa Tripathy Jean-Luc Bersillon Krishna Gopal | 2005 | Separation and Purification Technology2005，，3： | 1 |
| 19 | Adsorption of Cd^2+ on Hydrous Manganese Dioxide from Aqueous Solutions 显示文摘 | Sushree Swarupa Tripathya | 2006 | esalination2006，194，： | 1 |
| 20 | Comments on'Review of the role of diagnostic modalities and imaging findings in the COVID-19 pandemic'显示文摘The present letter to the editor corresponds to the article entitled“Comprehensive literature review on the radiographic findings,imaging modalities,and the role of radiology in the coronavirus disease 2019(COVID-19)pandemic”by Pal et al,published in World J Radiol.2021;13(9):258-282.With zero to unknown prevalence,COVID-19 has created a heterogeneous and unforeseen situation across the world.Healthcare providers encountered new challenges in image interpretation,characterization,and prognostication of the disease.Pal et al delineated the radiological findings,which would guide the radiologists to identify the early signs of severe infection. | Sai Swarupa R Vulasala Dheeraj R Gopireddy Priya Bhosale Mayur K Virarkar | 2022 | World Journal of Radiology2022，14，2： | 0 |
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