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| 1 | Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants显示文摘The process of carcinogenesis is tightly regulated by antioxidant enzymes and matrix degrading enzymes, namely, matrix metalloproteinases(MMPs). Degradation of extracellular matrix(ECM) proteins like collagen, proteoglycan, laminin, elastin and fibronectin is considered to be the prerequisite for tumor invasion and metastasis. MMPs can degrade essentially all of the ECM components and, most MMPs also substantially contribute to angiogenesis, differentiation, proliferation and apoptosis. Hence, MMPs are important regulators of tumor growth both at the primary site and in distant metastases; thus the enzymes are considered as important targets for cancer therapy. The implications of MMPs in cancers are no longer mysterious; however, the mechanism of action is yet to be explained. Herein, our major interest is to clarify how MMPs are tied up with gastrointestinal cancers. Gastrointestinal cancer is a variety of cancer types, including the cancers of gastrointestinal tract and organs, i.e., esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The activity of MMPs is regulated by its endogenous inhibitor tissue inhibitor of metallopro-teinase(TIMP) which bind MMPs with a 1:1 stoichiometry. In addition, RECK(reversion including cysteinerich protein with kazal motifs) is a membrane bound glycoprotein that inhibits MMP-2,-9 and-14. Moreover, α2-macroglobulin mediates the uptake of several MMPs thereby inhibit their activity. Cancerous conditions increase intrinsic reactive oxygen species(ROS) through mitochondrial dysfunction leading to altered protease/anti-protease balance. ROS, an index of oxidative stress is also involved in tumorigenesis by activation of different MAP kinase pathways including MMP induction. Oxidative stress is involved in cancer by changing the activity and expression of regulatory proteins especially MMPs. Epidemiological studies have shown that high intake of fruits that rich in antioxidants is associated with a lower cancer incidence. Evidence indicates that some antioxidants inhibit the growth of malignant cells by inducing apoptosis and inhibiting the activity of MMPs. This review is discussed in six subchapters, as follows. | Sugreev Verma Kousik Kesh Nilanjan Ganguly Sayantan Jana Snehasikta Swarnakar | 2014 | World Journal of Biological Chemistry2014，5，3： | 10 |
| 2 | Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress显示文摘AIM: To examine the effect of doxycycline on the activity of matrix metalloproteinases (MMPs) and oxidative stress in gastric tissues of rats following gastric injury.METHODS: Gastric ulcers were generated in rats by administration of 70% ethanol,and activity of doxycycline was tested by administration 30 min prior to ethanol.Similarly,the effect of doxycycline was tested in an indomethacin-induced gastric ulcer model.The activities and expression of MMPs were examined by zymography and Western blot analysis.RESULTS: Gastric injury in rats as judged by elevated ulcer indices following exposure to ulcerogen,either indomethacin or ethanol,was reversed significantly by doxycycline.Indomethacin-induced ulcerated gastric tissues exhibited about 12-fold higher proMMP-9 activity and about 5-fold higher proMMP-3 activity as compared to control tissues.Similarly,ethanol induced about 22-fold and about 6-fold higher proMMP-9 and proMMP-3 activities,respectively,in rat gastric tissues.Both proMMP-9 and MMP-3 activities were markedly decreased by doxycycline in ulcerogen treated rat gastric tissues.In contrast,the reduced MMP-2 activity in ulcerated tissues was increased by doxycycline during ulcer prevention.On the other hand,doxycycline inhibited significantly proMMP-9,-2 and -3 activities in vitro.In addition,doxycycline reduced oxidative load in gastric tissues and scavenged H2O2 in vitro.Our results suggest a novel regulatory role of doxycycline on MMP-2 activity in addition to inhibitory action on MMP-9 and MMP-3 during prevention of gastric ulcers.CONCLUSION: This is the first demonstration of dual action of doxycycline,that is,regulation of MMP activity and reduction of oxidative stress in arresting gastric injury. | Laishram Pradeepkumar Singh Amartya Mishra Debjit Saha Snehasikta Swarnakar | 2011 | World Journal of Gastroenterology2011，17，28： | 5 |
| 3 | Fractal dimension estimation using continuous alternating sequential filter pyramid显示文摘 | SWARNAKAR V ACHARYA R S | 1995 | Image Processing1995，，13： | 1 |
| 4 | Curcumin regulates expression and activity of matrix metalloproteinases-9 and-2 during prevention and healing of indomethacin-induced gastric ulcer显示文摘 | Swarnakar S Ganguly K | | 0，，10： | 1 |
| 5 | Oxidative dehydrogenation of ethane on vanadium-molybdenum oxide and vanadium-niobium-mo- lybdenum oxide eatalysts显示文摘 | Burch R Swarnakar R | 1991 | Appl Catal1991，70，1： | 1 |
| 6 | Enhanced dermal delivery of aey- elovir using nanostruetured lipid carriers 显示文摘 | Jain S Mistry MA Swarnakar NK | 2011 | Drug Deliv TranM Res2011，1，5： | 1 |
| 7 | α2-Macroglobulin does not function as a C3 homologue in the plasma hemolytic system of the American horseshoe crab, Limulus显示文摘 | Armstrong P B Melchior R Swarnakar S | 1998 | Mol Immunol1998，35，： | 1 |
| 8 | Fractal dimension estimation using continuous alternating sequential filter pyramid显示文摘 | Swarnakar V Acharya R S | 1995 | Image Pro-cessing1995，13，： | 1 |
| 9 | Thermal expansion and lattice parameters of shaped metal deposited Ti–6Al–4V显示文摘 | Akhilesh Kumar Swarnakar Omer Van der Biest Bernd Baufeld | 2010 | Journal of Alloys and Compounds2010，，6： | 1 |
| 10 | E- vent timing and shape analysis of vibration bursts from power circuit breakers 显示文摘 | POLYCARPOU A A SOOM A SWARNAKAR V | 1996 | IEEE Transaction on Power Delivery1996，11，2： | 1 |
| 11 | Catalytic activity of Ti-and Al-pillared montmorillonite and beidellite for cumene cracking and hydrocracking显示文摘 | Kydd R A Brandt K B Swarnakar R | 1996 | Applied Catalysis1996，142，1： | 1 |
| 12 | Enhanced an- titumor efficacy and counterfeited cardiotoxicity of combinatorial oral therapy using doxorubicin and co- enzyme Q10-1iquid crystalline nanoparticles in com- parison with intravenous Adriamycin 显示文摘 | SWARNAKAR K THANKI K JAIN S | 2014 | Nanomedi- cine: Nanotechnology Biology and Medicine2014，10，6： | 1 |
| 13 | Polyelectrolyte stabilized multilayered liposomes for oral delivery of paclitaxel显示文摘 | Jain S Kumar D Swarnakar NK | 2012 | Biomaterials2012，33，28： | 1 |
| 14 | En-hanced oromucosal delivery of progesterone via hexosomes显示文摘 | Swarnakar N K Jain V Dubey V Mishra D Jain N K | 2007 | Pharma Res2007，24，： | 1 |
| 15 | Oxidative dehydrogenation of ethane on vanadium-molybdenum oxide and vanadium-niobium-molybdenum oxide catalysts 显示文摘 | R Burch R Swarnakar | 1991 | Appl Catal1991，70，1： | 1 |
| 16 | Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol- induced liver injury in mice显示文摘 | Mishra A Paul S Swarnakar S | 2011 | Biochimie2011，93，5： | 1 |
| 17 | Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol- induced liver injury in mice显示文摘 | MISHRA A PAUL S SWARNAKAR S | 2011 | Biochimie2011，93，5： | 1 |
| 18 | En- hanced oromucosal delivery of progesterone via hexo- somes 显示文摘 | SWARNAKAR N K JAIN V DUBEY V | 2007 | Pharm Res2007，24，12： | 1 |
| 19 | COVID-19,stigma,and people with disabilities:A mental health perspective显示文摘Discrimination is an age-old‘illness’irrespective of its context.Stigma is a common factor that has been associated with disability and coronavirus disease 2019.The public health impact of stigma on differently-abled people during this pandemic is not known and it is a poorly investigated and neglected area.It is important to address the current research need in the concerned area and its implications for public health policymaking and changes in practices that it requires.Together we can win the war against pandemics if we reduce the mental distancing in all perspectives. | Raktim Swarnakar Shreya Santra | 2022 | World Journal of Clinical Infectious Diseases2022，12，1： | 1 |
| 20 | Chronic gastric ulceration causes matrix metalloproteinases-9and-3augmentation:alleviation by melatonin显示文摘 | GANGULY K SWARNAKAR S | 2012 | Biochimie2012，94，： | 1 |
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