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| 1 | Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population显示文摘背景丙肝病毒(HCV ) 在全世界组成一个主要公共健康问题,特别在开发象巴基斯坦一样的国家。在这研究,我们估计了在长期的丙肝病人的治疗在这研究由性,年龄,和病毒的 load.Methods 分类的干扰素(INF ) 的结果,有遗传型 3 的 750 个 HCV 积极病人被选择,从哪个 616 完成了全部治疗。他们的个人历史,支持处理的 HCV RNA 和浆液丙氨酸 transaminase (中高音) 是 quantified.Patients 与 INF- 2b 的联合治疗被对待 300 万个单位(三次一个星期) 正 ribavirin (1000-1200mg 每天) 为 24 个星期。在 24 个星期以后,他们的 HCV RNA 和浆液中高音水平是从 616 个病人,的 quantified.Results (63.5%) 391 对治疗学的政体(加 ribavirin 的 INF- 2b ) 作出回应。在应答者之中, 27.1% 是男人, 36.4% 是女人。最好的治疗反应在有 Iow 的病人被观察病毒的负担 8 ?????牴湡睳汥 吗?? | Hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza Javaid Irfan Yasir Waheed Iram Bilal Abida Raza | 2011 | Chinese Medical Journal2011，，9： | 6 |
| 2 | TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity显示文摘在 Ca2+ 动态平衡的神经毒素和改变与 Parkinson 的疾病(PD ) 被联系了,但是操作店的 Ca2+ 入口隧道的角色很好没被理解。以前的研究在短暂受体潜力蛋白质 1 导致的 SH-SY5Y 房间和 cytoprotection (TRPC1 ) 上显示出 salsolinol 和 1-methyl-4-phenylpyridinium 离子的 neurotoxicity。在现在的学习, N-methyl-(R)-salsolinol 在 TRPC1 表示上为它的细胞的毒性和效果被测试。MTT (3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazolium 溴化物) 试金, DAPI (4,6-diamidino-2-phenylindole ) ,荧光黄 isothiocyanate-Annexin-V/propidium 碘化物,西方的污点分析,和标记的 JC-1 表明三显示的药能导致 caspase 依赖的、调停 mitochondrial 的 apoptosis。到显示的药的 SH-SY5Y 房间的暴露在调停 thapsigargin 的 Ca2+ 流入和 TRPC1 表示导致了重要减少。Immunocytochemistry 实验表明神经毒素处理导致了 TRPC1 translocation 到细胞质。一起拿,我们的结果显示有神经毒素的处理可以改变 Ca2+ 动态平衡并且导致调停 mitochondrial 的 caspase 依赖的 cytotoxicity, PD 的一个重要特征。 | Abida Arshad Xuechai Chen Zhenzhen Cong Hong Qing Yulin Deng | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 4 |
| 3 | An evaluation of OSOM BV blue test in the diagnosis of bacterial vaginosis显示文摘Objective:To determine the prevalence of bacterial vaginosis(BV) in patients with vaginal discharge and evaluate the efficacy of OSOM BV blue test in diagnosis.Methods:OSOM BV blue test,a rapid diagnostic test based on the principle of detection of bacterial sialidase activity in vaginal fluid specimens was conducted.A total of 405 patients in the reproductive age group(15- 45 years) having vaginal discharge were included in the study along with 10 healthy age-matched controls.Two high vaginal swabs were collected aseptically from each patient.One swab was used to make smear for gram staining,and the other was for OSOM BV blue test.Amine test and vaginal pH test were taken as well.Results:The prevalence of bacterial vaginosis was 60.7%. OSOM BV blue test showed good efficacy,as compared with gram staining in diagnosing BV.The sensitivity and specificity of OSOM BV blue test were 97.6%and 97.5%respectively.Amsel’s criteria diagnosed 180(44.4%) cases of BV and had sensitivity and specificity of 67.1%and 90.6%respectively.Thus the performance of OSOM BV blue was better than the methods based on Amsel’s criteria.Conclusions:OSOM BV blue test is an efficacious bed side test,helpful in rapidly making an accurate diagnosis of BV in setups lacking laboratory facilities or expert microbiologists. | Fatima Shujatullah Haris M Khan Razia Khatoon Tamkin Rabbani Abida Malik | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 3 |
| 4 | Pulmonary and Cardiovascular Complications of Obesity: An Autopsy Study of 76 Obese Subjects显示文摘 | Haque Abida K Gadre Swarupa Taylor Jerrod Haque Sajid A Freeman Daniel Duarte Alex | 2008 | Archives of Pathology & Laboratory Medicine2008，，9： | 2 |
| 5 | bla_(CTX-M),bla_(TEM),and bla_(SHV) in Enterobacteriaceae from North-Indian tertiary hospital:high occurrence of combination genes显示文摘Objective:To delineate the frequency of occurrence of blaCTX-M,blaTEM,and blaSHV in Enterobacteriaceae from North-Indian tertiary hospital.Methods:A random collection of a subset of 45 Escherichia coli(E.coli) and 28 Klebsiella pneumoniae(K.pneumoniae) that was resistant to a third generation cephalosporin and obtained during 2007-2008 was selected for detailed screening for blaCTX-M,blaTEM,and blaSHV by monoplex PCRs.The isolates demonstrating the presence of blaCTX-M alleles were characterized for the specific CTX-M-genogroup by using a multiplex PCR.Results:Resistance to cefoperazone,ceftazidime,ceftriaxone,cefotaxime, cefoxitin and piperacillin was 100%each in K.pneumoniae isolates,whereas these resistancerates for E.coli isolates were 93.1%,83.8%,91.9%,93.6%,97.3%and 97.1%,respectively. Concomitant resistance to aminoglycosides,quinolones and aztreonam was also noticed.Presence of any of the bla genes(blaCTX-M,blaTEM,and blaSHV) was noticed in a total of 28(38.4%) isolates of the 73 isolates studied.Many isolates demonstrated occurrence of these genes in various combinations.blaCTX-M,blaTEM,and blaSHV were noticed in 28.8%,10.9%and 13.7%isolates, respectively.Multiplex PCR in blaCTX-M harboring isolates demonstrated the presence of CTX-MGenogroup -1 and sequencing for the specific CTX-M-type revealed presence of CTX-M-15 type. RAPD typing showed wide diversity in isolates.Conclusions:This is amongst the premier report describing the simultaneous occurrence of bloTEM,blaSHV,and blaampC in Indian Enterobacteriaceae and that wider dissemination of these genes,as demonstrated by diversity of isolates,raises concern and emphasizes a need for extensive search for the presence of these gene pools in Indian subcontinent. | Mohammed Shahid Anuradha Singh Farrukh Sobia Mohammad Rashid Abida Malik Indu Shukla Haris Manzoor Khan | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，2： | 2 |
| 6 | A prospective evaluation of CT features predictive of intra-abdominal hypertension and abdominal compartment syndrome in critically ill surgical patients显示文摘 | Bahrania AZ Abida GH Sahgala E | 2007 | Clin Radiol2007，62，7： | 1 |
| 7 | Toxic fluoride and arsenic contaminated groundwater in the Lahore and Kasur districts, Punjab, Pakistan and possible contaminant sources 显示文摘 | Abida Farooqi Harue Masuda Nousheen Firdous | 2006 | Environmental Pollution2006，，7： | 1 |
| 8 | Challenges and guidelines for clinical trial of herbal drugs显示文摘 | Abida Parveen Bushra Parveen Rabea Parveen Sayeed Ahmad | 2015 | Journal of Pharmacy and Bioallied Sciences2015，，： | 1 |
| 9 | Etiology and clinico- epidemiological profile of acute viral encephalitis in children of western Uttar Pradesh, India显示文摘 | Beig FK Malik Abida Rizvi M | 2010 | Int J Infect Dis2010，14，2： | 1 |
| 10 | The association of altered RAR expression with the cervical lesion pathogenesis显示文摘 | Nafeisha K Hui H Abida A | 2011 | Chinese-GermanJ Clin Oncot2011，10，9： | 1 |
| 11 | Comparative study of the physico-chemical properties of rice and corn starches grown in Indian temperate climate显示文摘 | Abida Ali Touseef Ahmed Wani Idrees Ahmed Wani Farooq Ahmad Masoodi | 2014 | Journal of the Saudi Society of Agricultural Sciences2014，，： | 1 |
| 12 | Distribution of highly arsenic and fluoride contaminated groundwater from east Punjab, Pakistan, and the controlling role of anthropogenic pollutants in the natural hydrological cycle 显示文摘 | ABIDA FAROOQI HARUE MASUDA | 2007 | Geochemical Journal2007，41，： | 1 |
| 13 | Grass swale-perforated pipe sys- tems for stormwater management 显示文摘 | Abida H Sabourin J F | 2006 | J Irrig Drain Eng2006，132，1： | 1 |
| 14 | RARβ在宫颈癌及癌前病变中的表达调控和意义(英文)显示文摘Objective:Previous reports have shown that the gene promoter region of retinoic acid receptor β(RARβ) was hypermethylated in cervical carcinoma,implying the inhibition of gene transcription.The aim of this study was to investigate the association of cervical cancer development with the RARβ gene expression at the mRNA and protein level to assess the impact of RARβ as a marker for early detection of the cancer.Methods:We collected 126 cases of formalin fixed and paraffin embedded cervical tissue specimens as well as 37 cases of fresh tissue samples from women with cervicitis,cervical intraepithelial neoplasia(CIN) and cervical squamous cell carcinoma(CSCC).The RARβ mRNA and protein expression was detected by quantitative RT-PCR and immunohistochemistry,respectively.Results:(1) The mRNA expression of RARβ in CIN and cervical cancer was markedly decreased compared to cervicitis with a statistically very significant difference,but no difference was found between CIN and cervical cancer.(2) RARβ protein was normally expressed in the epithelial cells of cervicitis and partially lost in a few cases,but with the development of cervical lesion pathogenesis and cancer,a significant loss of protein expression was detected in CIN(38%) and CSCC(57%) compared to cervicitis(P < 0.01).Conclusion:The downregulation of RARβ transcription or loss of protein expression is an important indicator of cervical cancer and its precursur lesions.The detection of RARβ expression coupled with aberrant methylation of the gene may become a biomarker for the early prognosis or diagnosis of the cancer. | Nafeisha Kadeer Hui He Abida Abudoukadeer Anaguli Ababaikeli Abulizi Abudula | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，9： | 1 |
| 15 | P53-Dependent and p53-independent activation of autophagy by ARF显示文摘 | ABIDA W M GU W | 2008 | Cancer Res2008，8，： | 1 |
| 16 | Catalase and lipid peroxidation values in ser- um of tunisian patients with pemphigus vul- garis and foliaceus 显示文摘 | Abida O Ben Mansour R Gargouri B | 2012 | Biol Trace Elem Res2012，150，13： | 1 |
| 17 | Analysis of variables and interactions among variables associated with a sustained virological response to pegylated interferon alfa-2a plus ribavirin in hepatitis C virus genotype 3-infected patients显示文摘 | Hafsa Aziz Abida Raza Yasir Waheed Uzma Gill Muzaffar Lateef Gill | 2012 | International Journal of Infectious Diseases2012，，8： | 1 |
| 18 | Analysis of heavy metals in water, sediments and fish samples of Madivala Lakes of Bangalore, Karnataka 显示文摘 | Abida B Harikrishna S Irfanulla K | 2009 | International Journal of Chemistry Technology Research2009，1，2： | 1 |
| 19 | Biomarkers of oxidative stress in epidermis of Tunisian pemphigus foliaceus patients 显示文摘 | Abida O Gargoufi B Ben Mansour R | 2013 | Journal of the European Academy of Derma- tology and Venereology2013，27，3： | 1 |
| 20 | Evaluation of prognostic factors for Peg Interferon alfa-2b plus ribavirin treatment on HCV infected patients in Pakistan显示文摘 | Hafsa Aziz Muzaffar Latif Gil Yasir Waheed Uzama Adeeb Abida Raza Iram Bilal Muhammad Amin Athar | 2011 | Infection Genetics and Evolution2011，，3： | 1 |
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