|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 3 | Hidden risks associated with conventional short intermittent hemodialysis:A call for action to mitigate cardiovascular risk and morbidity显示文摘The development of maintenance hemodialysis(HD)for end stage kidney disease patients is a success story that continues to save many lives.Nevertheless,intermittent renal replacement therapy is also a source of recurrent stress for patients.Conventional thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities,increases cardiovascular risk,and exacerbates disease burden.Altering cycles of fluid loading associated with cardiac stretching(interdialytic phase)and then fluid unloading(intradialytic phase)likely contribute to cardiac and vascular damage.This unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burdenof treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory,inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed thedialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidityassociated with conventional intermittent HD appears to be a priority for improving patientexperience and reducing disease burden. In this in-depth review, we summarize the hidden effectsof intermittent HD therapy, and call for action to improve delivered HD and develop treatmentschedules that are better tolerated and associated with fewer adverse effects. | Bernard Canaud Jeroen P Kooman Nicholas M Selby Maarten Taal Andreas Maierhofer Pascal Kopperschmidt Susan Francis Allan Collins Peter Kotanko | 2022 | World Journal of Nephrology2022，11，2： | 2 |
| 4 | A Resonant Accel- erometer with Two-Stage Micro-Leverage Mechanisms Fabricated by SOI-MEMS Technology 显示文摘 | Susan X P Su Henry S Yang Alice M Agogino | 2005 | IEEE Sensors Journal2005，5，6： | 1 |
| 5 | Early warning fire detection system using a probabilistic neural network 显示文摘 | SUSAN L ROSE P | 2003 | Fire Technology2003，39，： | 1 |
| 6 | Comparison between electron-beam and chemical crosslinking of silicone rubber显示文摘 | Masoud F Susan D Farhad P | 2006 | Nuclear Instruments and Methods in Physics Research B2006，243，2： | 1 |
| 7 | The ecology of medical care revisited显示文摘 | Larry A Green George E Fryer Jr Barbara P Yawn David lanier Susan M Dovey | 2001 | The New England Journal of Medicine2001，334，26： | 1 |
| 8 | The role of plants in ecologically engineered wastewater treatment systems显示文摘 | Susan B P John M T | 1996 | Ecol Eng1996，6，1： | 1 |
| 9 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | Susane E L Michael K T Anthony P J T | 1985 | J General Microbiology1985，131，： | 1 |
| 10 | The wing in yeast heat shock transcription factor(HSF) DNA-binding domain is required for full activity 显示文摘 | MARCOv P C SUSAN T H CELIA J H | 2001 | Nucleic Acids Res2001，29，8： | 1 |
| 11 | Closure of the cere- bailer vermis: evaluation with secondtrimescer US显示文摘 | Bryann B Allan SN Susan P | 1994 | Ra- diology1994，193，3： | 1 |
| 12 | Multidrug Resistance Proteins\sMRP3,MRP1,and MRP2 in Lung Cancer:Correlation of Protein Levels\swith Drug Response and Messenger RNA Levels显示文摘 | Leah C Barbara G Susan P | 2001 | Clinical Cance\sResearch2001，7，： | 1 |
| 13 | Timing of Class Ⅱ treatment:Skeletal changes comparing 1-phase and 2-phase treatment显示文摘 | Calogero Dolce Susan P McGorray Lisamarie Brazeau | 2007 | Am J Orthod Dentofac Orthod2007，132，： | 1 |
| 14 | Modeling non calamitous individual tree mortality using logistic regression, neural networks, and support vector methods 显示文摘 | SUSAN L KING KRISTIN P BENNETT SHANNON LIST | 2000 | Computers and Electronics in Agriculture2000，27，3： | 1 |
| 15 | The role of emotion in explaining consumer satisfaction and future behavioural intention 显示文摘 | MARTIN D SUSAN H ADRIAN P | 2008 | Journal of Services Marketing2008，22，3： | 1 |
| 16 | 16S ribosomal DNA amplification t'or phylogenetic study 显示文摘 | William GW Susan MB Dale A P | 1991 | Journal of Bacteriology1991，1，： | 1 |
| 17 | Enhanced cofermentation of glucose and xylose by recombinantSaccharomyces yeast strains in batch and continuous operating modes显示文摘 | t SUSAN T TOON GEORGE P PHILIPPIDIS NANCY W Y HO | 1997 | Applied Bio- chemistry and Biotechnology1997，6365，1： | 1 |
| 18 | Socioeconomic status in health research: title and subtitle break one size doos not fit all显示文摘 | Paula A Braveman M M Catherine Cubbiu P Susan Ege-ler P et at | 2005 | jama-Journal of the American Medical Association2005，294，22： | 1 |
| 19 | Regulation of Cu,Zn superoxide dismutase with copper 显示文摘 | Susan S P Edward D H | 1991 | Biochem J1991，274，： | 1 |
| 20 | Bioinformatics and management sci- ence: Some common tools and techniques显示文摘 | All E A Susan P H | 2004 | Operations Research2004，52，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员