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| 1 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 2 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 3 | Selective and sensitive method for PCR amplification of Escherichia coli 16S rRNA genes in soil 显示文摘 | Sabat G Rose P HiekeyiWJ | 2000 | Appl Environ Mierobiol2000，66，2： | 1 |
| 4 | Sequential feeding of whole wheat to growing broiler chickens 显示文摘 | Rose S P Fielden M Foote W R | 1995 | Br Poult Sci1995，36，： | 1 |
| 5 | Redicting Business Failure: A Macroeconomic Perspective 显示文摘 | Rose Peter S Andrews Wesley T Giroux Gary A P | 1982 | Journal of Accounting Auditing and Finance1982，，1： | 1 |
| 6 | Effect of ethanol on activity of the plasma-membrane ATPase in and accumulation of glycine by Saccharomyces cerevisiae 显示文摘 | CARTWRIGHT C P VEAZEY F J ROSE A H | 1987 | J Gen Microbiol1987，133，： | 1 |
| 7 | Reflected Blast Wave Resultants Behind Cantilever Walls:A New Prediction Technique 显示文摘 | CHAPMAN T C ROSE T A SMITHS P D | 1995 | International Journal of Impact Engineering1995，16，3： | 1 |
| 8 | The angle stable locking-proximal-humerus-plate (LPHP) for proximal humeral fractures using a small anterior lateral deltoid splitting approach technique and first results显示文摘 | Lill H Hepp P Rose T | 2004 | Zentralbl Chir2004，129，1： | 1 |
| 9 | Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias 显示文摘 | Allford S L Hunt BJ Rose P | 2003 | Br J Haemotol2003，120，4： | 1 |
| 10 | Multiple product inhibition and growth modeling of Clostridium butyricum and Klebsiella pneumoniae in glycerol fermentation 显示文摘 | ZENG A P ROSE A BIEBL H | 1994 | Biotechnol Bioeng1994，44，： | 1 |
| 11 | Early warning fire detection system using a probabilistic neural network 显示文摘 | SUSAN L ROSE P | 2003 | Fire Technology2003，39，： | 1 |
| 12 | Facade failure effects on blast propagation along city streets显示文摘 | SMITH P D ROSE T A KRAHE S L | 2003 | Structures and Buildings2003，156，4： | 1 |
| 13 | The angle stable locking proximal humerus plate(LPHP) for proximal humeral fractures using a small anterior lateral deltoid splitting approach technique and first results显示文摘 | Hill H Hepp P Rose T | 2004 | Zentralbl Chir2004，129，1： | 1 |
| 14 | The Locking-proximal- humerus-plate (LPHP) for proximal humeral fractures using a small anterlor-lateral-del approach-techniq toid-splitting- ue and first results 显示文摘 | Lill H Hepp angle stable P Rose T | 2004 | Zentralbl CMr2004，129，： | 1 |
| 15 | The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages显示文摘 | Whiteman M Li L Rose P | | 0，，10： | 1 |
| 16 | NonaxisymmetricTurbine End Wall Design: Part I -Three-Dimensional Lin-ear Design System 显示文摘 | Harvey N Rose MG Seaman P | 2000 | Journal of Turbomachinery2000，122，： | 1 |
| 17 | A phase Ⅱ trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a gynecologic oncology group study显示文摘 | Brunetto V L Vanlel | 2000 | Gynecol Oncol2000，78，2： | 1 |
| 18 | Carbon and nitrogen in the light fraction of a forest soil: Vertical distribution and seasonal patterns显示文摘 | Spycher G Sollins P Rose S | 1983 | Soil Science1983，135，2： | 1 |
| 19 | The effects of selective eytokine inhibitory drugs (CC - 10004 and CC - 1088) on VEGF and IL - 6 expression and apoptosis in myeloma and endothelial cell co-cultures 显示文摘 | Molostvov G Morris A Rose P | 2004 | Br J Haematology2004，124，3： | 1 |
| 20 | An apparatus for ultraviolet B irradiation of small volumes of biological fluid under controlled oxygen tension显示文摘 | Richer S P Rose R C Gogia R | 1996 | Optom Vis Sci1996，73，11： | 1 |
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