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| 1 | Evolution of transanal total mesorectal excision for rectal cancer:From top to bottom显示文摘The gold standard for curative treatment of locally advanced rectal cancer involves radical resection with a total mesorectal excision(TME). TME is the most effective treatment strategy to reduce local recurrence and improve survival outcomes regardless of the surgical platform used. However, there are associated morbidities, functional consequences, and quality of life(QoL) issues associated with TME; these risks must be considered during the modern-day multidisciplinary treatment for rectal cancer. This has led to the development of new surgical techniques to improve patient, oncologic, and QoL outcomes. In this work, we review the evolution of TME to the transanal total mesorectal excision(TaTME) through more traditional minimally invasive platforms. The review the development, safety and feasibility, proposed benefits and risks of the procedure, implementation and education models, and future direction for research and implementation of the TaTME in colorectal surgery. While satisfactory short-term results have been reported, the procedure is in its infancy, and long term outcomes and definitive results from controlled trials are pending.As evidence for safety and feasibility accumulates,structured training programs to standardize teaching,training, and safe expansion will aid the safe spread of the TaTME. | Sameh Hany Emile F Borja de Lacy Deborah Susan Keller Beatriz Martin-Perez Sadir Alrawi Antonio M Lacy Manish Chand | 2018 | World Journal of Gastrointestinal Surgery2018，10，3： | 18 |
| 2 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 3 | 卫生政策分析:概念和方法的思考与挑战显示文摘许多专家学者就卫生政策分析开展了大量研究,但很少关注如何进行政策分析以及需要什么样的研究设计、理论和方法。本文着眼于卫生政策分析的环境以及面临的挑战,借鉴中低收入国家中一些卫生政策分析的框架、理论、方法和设计,列举了最近的研究案例,并探讨了案例研究的意义以及研究设计的必要性,发现卫生政策研究者的角色、反思和定位在研究过程中非常重要。最后从理论、方法学和研究人员的反思等角度提出了促进卫生政策分析的建议。 | Gill Walt Jeremy Shiffman Helen Schneider Susan F Murray Ruairi Brugha Lucy Gilson | 2012 | 中国卫生政策研究2012，5，12： | 3 |
| 4 | Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line显示文摘AIM To determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with inflammatory bowel disease.METHODS Normal human colon epithelial cells(ATCC?CRL.1790?)were stimulated with either heat killed E.coli or heat killed murine cecal contents(HKC)and examined for several relevant biomarkers associated with inflammation and oxidative stress including cytokine production,mitochondrial autophagy and oxidant status.TNFα,IL-1βand IL-8 protein concentrations were measured within the supernatants.Fluorescent microscopy was performed to quantify the production of reactive oxygen species(ROS)using an oxidation responsive fluorogenic probe.Mitochondrial morphology and mitochondrial membrane potential was assessed by dual staining using COXIV antibody and a dye concentrating in active mitochondria.Mitochondrial ROS scavenger was used to determine the source of ROS in stimulated cells.Autophagy was detected by staining for the presence of autophagic vesicles.Positive controls for autophagy and ROS/RNS experiments were treated with rapamycin and chloroquine.Mitochondrial morphology,ROS production and autophagy microscopy experiments were analyzed using a custom acquisition and analysis microscopy software(Image J).RESULTS Exposing CRL.1790 cells to microbial challenge stimulated cells to produce several relevant biomarkers associated with inflammation and oxidative stress.Heat killed cecal contents treatment induced a 10-12fold increase in IL-8 production by CRL.1790 cells compared to unstimulated controls at 6 and 12 h(P<0.001).Heat killed E.coli stimulation resulted in a4-5 fold increase in IL-8 compared to the unstimulated control cells at each time point(P<0.001).Both heat killed E.coli and HKC stimulated robust ROS production at 6(P<0.001),and 12 h(P<0.01).Mitochondrial morphologic abnormalities were detected at 6 and12 h based on reduced mitochondrial circularity and decreased mitochondrial membrane potential,P<0.01.Microbial stimulation also induced significant autophagy at 6 and 12 h,P<0.01.Lastly,blocking mitochondrial ROS generation using mitochondrial specific ROS scavenger reversed microbial challenge induced mitochondrial morphologic abnormalities and autophagy.CONCLUSION The findings from this study suggest that CRL.1790cells may be a useful alternative to other colon cancer cell lines in studying the mechanisms of oxidative stress events associated with intestinal inflammatory disorders. | Nandakumar Packiriswamy Kari F Coulson Susan J Holcombe Lorraine M Sordillo | 2017 | World Journal of Gastroenterology2017，23，19： | 3 |
| 5 | Knowledge, perception and practices about malaria, climate change, livelihoods and food security among rural communities of central Tanzania显示文摘Background:Understanding the interactions between malaria and agriculture in Tanzania is of particular significance when considering that they are the major sources of illness and livelihoods.The objective of this study was to determine knowledge,perceptions and practices as regards to malaria,climate change,livelihoods and food insecurity in a rural farming community in central Tanzania.Methods:Using a cross-sectional design,heads of households were interviewed on their knowledge and perceptions on malaria transmission,symptoms and prevention and knowledge and practices as regards to climate change and food security.Results:A total of 399 individuals(mean age=39.8±15.5 years)were interviewed.Most(62.41%)of them had attained primary school education and majority(91.23%)were involved in crop farming activities.Nearly all(94.7%)knew that malaria is acquired through a mosquito bite.Three quarters(73%)reported that most people get sick from malaria during the rainy season.About 50%of the respondents felt that malaria had decreased during the last 10 years.The household coverage of insecticide treated mosquito nets(ITN)was high(95.5%).Ninety-six percent reported to have slept under a mosquito net the previous night.Only one in four understood the official Kiswahili term(Mabadiliko ya Tabia Nchi)for climate change.However,there was a general understanding that the rain patterns have changed in the past 10 years.Sixty-two percent believed that the temperature has increased during the same period.Three quarters of the respondents reported that they had no sufficient production from their own farms to guarantee food security in their household for the year.Three quarters(73.0%)reported to having food shortages in the past five years.About half said they most often experienced severe food shortage during the rainy season.Conclusion:Farming communities in Kilosa District have little knowledge on climate change and its impact on malaria burden.Food insecurity is common and community-based strategies to mitigate this need to be established.The findings call for an integrated control of malaria and food insecurity interventions. | Benjamin K Mayala Carolyn A Fahey Dorothy Wei Maria M Zinga Venera M Bwana Tabitha Mlacha Susan F Rumisha Grades Stanley Elizabeth H Shayo Leonard EG Mboera | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 6 | Shape memory effect and cristallographic investigation in VN containing Fe-Mn-Si-Cr alloys显示文摘 | Susan F Kenji H Kubo H | 2005 | Materials Transactions2005，45，3： | 1 |
| 7 | Comparison between electron-beam and chemical crosslinking of silicone rubber显示文摘 | Masoud F Susan D Farhad P | 2006 | Nuclear Instruments and Methods in Physics Research B2006，243，2： | 1 |
| 8 | The Impact of E-commerce on Supply Chain Relationships 显示文摘 | Susan L Golicic Donna F Davis Teresa M McCar-thy John T Mentzer | 2002 | International Journal of Physical Distribution & Logistics Management2002，32，910： | 1 |
| 9 | Sevoflurane provides Greather protection of the myocardium than propofol in undergoing off pump coronary artery by pass surgery显示文摘 | Conzen PF Susane F Christian D | 2003 | AnesthesioIogy2003，99，： | 1 |
| 10 | Sevoflurane prorides greate protection of the myocardium than propofol in patients undergoing of pump Coronary Artery By Surgery显示文摘 | Peter F ConzenMD Susane Fiseher | 2003 | Anesthesiology2003，99，4： | 1 |
| 11 | Paradoxes of technology:consumer cognizance,emotions,and coping strategies显示文摘 | MICK DAVID G SUSAN F | | 0，，： | 1 |
| 12 | Antibiosis revisited: bacterio- cins produced by dairy starter cultures显示文摘 | Susan F B Catherine G N | 1993 | Journal of Dairy Science1993，76，8： | 1 |
| 13 | Tumour stem cells and drug resistance显示文摘 | Michael D Tito F Susan B | 2005 | Nature Reviews2005，5，： | 1 |
| 14 | Strain localization in sand: plane versus triaxial compression显示文摘 | Khalid A Susan N Stein F | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，6： | 1 |
| 15 | Reaction synthesis of Ni-Al-based particle composite coatings 显示文摘 | SUSAN D F MISIOLEK W Z MARDER A R | 2001 | Metall Mater Trans2001，32，： | 1 |
| 16 | Consumers and their brands:developing relationship theory in consumer research显示文摘 | Susan F | 1998 | Journal of Consumer Research1998，24，3： | 1 |
| 17 | Closed suctioning of intubated neonates maintains better physiologic stability:a randomized trial显示文摘 | Angela K Susan B Sandra F | 2003 | J Perinatol2003，23，3： | 1 |
| 18 | Oxidation of Ni-Al-based electrodeposited composite coatings Ⅰ : Oxidation kinetics and morphglogy at 800 °C 显示文摘 | SUSAN D F MARDER A R | 2002 | Oxid Met2002，57，： | 1 |
| 19 | Effect of temperature on expression of genes encoding en- zymes for starch biosynthesis in developing wheat endosperm 显示文摘 | William J Hurkman Kent F McCue Susan B Ahenbach | 2003 | Plant Science2003，164，： | 1 |
| 20 | Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial显示文摘 | Christina Davies Hongchao Pan Jon Godwin Richard Gray Rodrigo Arriagada Vinod Raina Mirta Abraham Victor Hugo Medeiros Alencar Atef Badran Xavier Bonfill Joan Bradbury Michael Clarke Rory Collins Susan R Davis Antonella Delmestri John F Forbes Peiman Hadd | 2012 | The Lancet2012，，： | 1 |
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