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	题名	作者	年代	出处	被引量
1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
2	Effects of menopause on intraindividual changes in serum lipids, blood pressure, and body weight - - the Chin - Shah Community Cardiovascular Cohort study 显示文摘	Torng PL Su TC Sung FC	2002	Atherosclerosis2002，161，2：	1
3	Diagnosis of gastric cancer by serum proteomic Fingerprinting 显示文摘	Poon TC Sung JJ Chow SM	2006	Gastroenterology2006，130，6：	1
4	Prognostic impact of body mass index in patients undergoing coronary artery bypass surgery 显示文摘	Sung SH Wu TC Huang CH	2011	Heart2011，97，8：	1
5	Antitumor effect and enhance- ment of eytotoxic drug activity by cetuximab in nasopharyngeal carcinomacells 显示文摘	Sung FL Poon TC Hui EP	2005	In Vivo2005，19，1：	1
6	Antitumor effect and en- hancement of cytotoxic drug activity by cetuximab in na- sopharyngeal carcinoma cells 显示文摘	Sung FL Pooh TC Hui EP	2005	In Vivo2005，19，1：	1
7	Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvims pathogenicity显示文摘	Sung TC Roper RL Zhang Y	1997	EMBO J1997，16，15：	1
8	Mutagenesis of phospholipase D defines a superfamily including a trans- Golgi viral protein required for poxvirus pathogenicity 显示文摘	Sung TC Roper RL Zhang Y	1997	EMBO J1997，16，15：	1
9	Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for pexvirus pathogenicity 显示文摘	Sung TC Roper RL Zhang Y	1997	EMBO J1997，16，15：	1
10	Molecular analysis of mammalian phospholipase D2 显示文摘	Sung TC Altshuller YM Morris A J	1999	J Biol Chem1999，274，1：	1
11	Mammalian phospholipase D structure and regulation显示文摘	Frohman MA Sung TC Morris AJ	1999	Biochim Biophys Acta1999，1439，：	1
12	Antitumor effect and enhancement of cytotoxie drug activity by eetuximab in nasopharyngeal carcinoma cells显示文摘	Sung FL Poon TC Hui EP	2005	In Vivo2005，19，1：	1
13	Antitumor effect and enhancement of cytotoxic drug activity by cetuximab in nasopharyngeal carcinoma cell 显示文摘	Sung FL Poon TC Hui EP	2005	In Vivo2005，19，1：	1
14	Human ADP-ribo- sylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family显示文摘	Hammond SM Altshuller YM Sung TC	1995	J Biol Chem1995，270，29：	1
15	More on comlete convergence for arrays显示文摘	SUNG SH Volodin A I Hu TC	2005	Statist Probab Lett2005，71，：	1
16	Association between arsenic exposure and diabetes mellitus in Cambodia 显示文摘	Huang JW Cheng YY Sung TC	2014	Biomed Res Int2014，2014，68：	1
17	Antitumor effect and enhancement of cytotoxic drug activity by cetuximab in nasopharyngeal carcinoma cells显示文摘	Sung FL Poon TC Hui EP	2005	In Vivo2005，19，1：	1
18	Phospholipase D2, a dis- tinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization显示文摘	Colley WC Sung TC Roll R	1997	Curr Biol1997，7，3：	1
19	Orlistat improves endothelial function in obese adolescents: A randomised trial显示文摘	Clare CW Yu Albert M Li Karly OW Chan Ping Chook Jack TC Kam Chun T Au Raymond CH So Rita YT Sung Alison M McManus	2013	J Paediatr Child Health2013，，11：	1
20	Diagnosis of gastric cancer by serum proteomic fingerprinting 显示文摘	Poon TC Sung JJ Chow SM	2006	Gastroenterology2006，130，60：	1

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