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| 1 | Waist Circumference Reference Values for Screening Cardiovascular Risk Factors in Chinese Children and Adolescents显示文摘Objectives To explore the optimal threshold values of waist circumference(WC)for detecting cardiovascular(CV)risk factors among Chinese children and adolescents.Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China.CV risk factors in this study included hypertension(blood pressure above 95 percentile levels),dyslipidemia(with one or more of the following three indexes:TG≥1.7 mmol/L,TC≥5.18 mmol/L,and HDL-C≤1.04 mmol/L)and elevated glucose level(fasting plasma glucose ≥5.6 mmol/L).Receive-operating characteristic analysis(ROC)and logistic regression were employed to derive optimal age-and sex-specific waist circumference references for predicting CV risk factors.Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population,while a remarkable increasing trend occurred from the 90th percentile.The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls,which was at the 90th percentiles for detecting at least two of the above three CV risk factors.In comparison with children with waist circumference below the 75th percentile,the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile,and increased by 6 times among children with waist circumference above the 90th percentile.The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category.Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents,respectively. | GUAN-SHENG MA CHENG-YE JI JUN MA JIE MI R1TA YT SLING FENG XIONG WEI-LI YAN XIAO-QI HU YAN-PING LI SONG-M1NG DU HONG-YUN FANG AND J1NG-XIONG JIANG | 2010 | Biomedical and Environmental Sciences2010，23，1： | 25 |
| 2 | Waist Circumference Distribution of Chinese School-age Children and Adolescents显示文摘Background Waist circumference(WC),a proxy measure of central body fat,is a better predictor than overall body fat for cardiovascular risk factors in both adults and children.WC cutoffs have been established in many countries,but the national WC reference has not been developed in China.Objective To study the distribution of WC in a representative group of Chinese children for establishing Chinese WC cutoff points.Methods Cross-sectional data obtained from 15 mainland provinces and Hong Kong were collected.There were 160 225 children and adolescents aged 7-18 years old in total.The subjects were divided into five regional groups namely costal city,other city,north rural,south rural,and Hong Kong,for analyzing the distribution of WC.Results A large variation in WC distribution was found among the five groups for both sexes.Coastal city group had the highest P85 WC values consistently from the early school ages to 18-year-old compared with other groups.In contrast,south rural group had P85 values consistently lagged behind not only the city groups but also the north rural group.Hong Kong group had a high P85 WC at early ages,but because of the smaller increments of WC during adolescence,the P85 curve was gradually exceeded by the north rural groups.Catch-up trend was found in the two rural groups since the peak of puberty.These disparities were caused by not only socioeconomic and urban-rural factors but also north-south differences.Because of the regional variation of WC,a 'gradient' prevalence of central obesity was prospected among these groups.Comparisons of WC distributions between the Chinese and the U.S.A or Netherlands demonstrated the necessary of setting up China's own WC cutoffs.Sex and age-specific percentiles were obtained and smoothed by using LMS method.Conclusion The data obtained from this study could be used to develop national WC cutoff points for Chinese children and adolescents. | CHENG-YE JI RITA YT SUNG GUAN-SHENG MA JUN MA ZHONG-HU HE TIAN-JIAO CHEN | 2010 | Biomedical and Environmental Sciences2010，23，1： | 22 |
| 3 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 4 | Combined effects of cadmium and butachlor on soil enzyme activities and microbial community structure显示文摘 | Wang JH Lu YT Shen GQ | 2007 | 中国生物学文摘2007，21，7： | 14 |
| 5 | 雷公藤多甙对雄性大鼠抗生育作用的研究显示文摘本实验是观察雄性大鼠灌服雷公藤多甙(GTW)后,血清中FSH、LH,抑制素和睾酮水平,及睾网液中睾酮浓度与精子情况。结果表明:灌服16mg/kg·d连续2周或5周, 睾网液中睾酮水平与对照组相比无明显差异;灌服10mg/kg·d连续7周,血清促滤泡刺激素(FSH),间质细胞刺激素(LH)和抑制素水平与对照组相比也无显著差异。但灌服16mg/kg·d5周或10mg/kg·d7周,附睾精子活率明显下降,畸型率显著上升。在灌服5周组发现,附睾中精子畸型率又明显高于睾网液中精子畸型率。推测,灌服抗生育剂量GTW并不影响大鼠垂体—睾丸轴的内分泌功能,它可能直接作用于睾丸与附睾中精子的变态与成熟。 | 童建孙 许烨 张琢 王士民 钱绍祯 秦进喜 YT Sun D. M. de Kretser | 1991 | 中国药学杂志1991，26，2： | 11 |
| 6 | Climatic change over the past 8 000 years in Caohai District, Guizhou显示文摘THE δ13C and δ18O values of peat cellulose can be used as proxy indicators of humidity and temperature respectively. Peat archives are mainly utilized to interpret past climatic changes in terms of palynology. Here, we present a δ13C and δ18O record of climatic | Tao, FX Hong, YT Jiang, HB | 1997 | Chinese Science Bulletin1997，42，5： | 9 |
| 7 | Intrahepatic transplantation of hepatic oval cells for fulminant hepatic failure in rats显示文摘AIM:To evaluate the effect of intrahepatic transplantation of hepatic oval cells(HOC)on fulminant hepatic failure(FHF)in rats.METHODS:HOC obtained from rats were labeled with green fluocescent protein(GFP)or 5,6carboxyfluorescein diacetate succinmidyl ester(CFDASE).Cell fluorescence was observed under fluorescent microscope at 6,24,48 and 72 h after labeling.CFDASE labeled HOC(5×10 6 cells each rat)were injected into livers of rats with FHF induced by D-galactosamine.Serum albumin(ALB),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBil)levels were measured at different time points.Liver function of rats was examined on days 3,7,14 and 21 after HOC transplantation.RESULTS:The positive rate of GFP and CFDA-SE labeled HOC was 10%and 90%,respectively,with no significant change in cell viabilities.The survival rate was higher in HOC transplantation group than in control group,especially 48(9/15 vs 6/15)and 72 h(9/15 vs 4/15)after HOC transplantation.The serum ALT,AST and TBil levels were decreased while the serum Alb level was increased after HOC transplantation.Fluorescence became faded and diffused in liver tissues,suggesting that proliferation and differentiation occur in transplanted HOC.CONCLUSION:CFDA-SE is superior to GFP in labeling HOC,although fluorescence intensity is decreased progressively with cell division.HOC transplantation can improve the liver function and increase the survival rate of recipients. | Chen-Xuan Wu,Qi Zou,Zheng-Yan Zhu,Ying-Tang Gao,Yi-Jun Wang,Department of Hepatobiliary,The Third Center of Affiliated Hospital of Tianjin Medical University Key Laboratory of Artificial Cells of Tianjin,Tianjin 300170,China Author contributions:Wang YJ,Wu CH and Zou Q designed the research Zou Q,Zhu ZY,Gao YT performed the research Zou Q analyzed the data Wang YJ and Wu CX wrote the paper.Supported by Tianjin Science Committee,Grant No.05SYSYJC02600 and Tianjin Health Bureau,Grant No.05KYR01 | 2009 | World Journal of Gastroenterology2009，15，12： | 7 |
| 8 | Internal Oxidation of Cu-Al Alloy显示文摘 | Wu, JJ Zhang, Y Shen, YT Li, GB Lei, TQ | 1999 | Journal of Materials Science & Technology1999，15，5： | 5 |
| 9 | 血液透析患者冠状动脉药物洗脱支架植入术后的双联抗血小板治疗和临床结局显示文摘近日,临床肾脏领域权威杂志Clin J Am Soc Nephrol上发表了一篇研究文章,研究人员试图明确血液透析患者冠状动脉药物洗脱支架(drug—eluting stent,DES)植入后进行双联抗血小板治疗(dual antiplatelet therapy,DAPT)的益处和风险。血液透析患者接受DES和DAPT治疗后进行巢式病例对照分析。DES植入后1年内心肌梗死或死亡的病例与对照患者一一配对。主要结局是死亡和心肌梗塞;次要结局是缺血性卒中、血运重建和大出血。 | 王建中 Chen YT Chen HT Hsu CY | 2017 | 中华肾病研究电子杂志2017，6，2： | 5 |
| 10 | 经桡动脉冠状动脉介入治疗中5F与6F导引导管的对比研究显示文摘目的比较5French(5F)及6French(6F)导引导管在经桡动脉冠状动脉介入治疗(TRI)患者中的安全性及有效性。方法共纳入2009年2月至2010年3月患者,收集相关资料录入数据库,包括患者基线临床资料、导引导管的尺寸、靶血管、靶病变的特点、手术的成功率、手术失败原因、经桡动脉冠状动脉介入治疗手术的成功率及失败原因、患者住院期间主要不良心血管事件率及术后桡动脉闭塞率。结果连续纳入患者共185例,接受195次经桡动脉冠状动脉介入治疗术,平均年龄(57±11)岁(33~81岁);其中54例患者纳入6F导引导管组,共进行56次手术,治疗89处病变;138例患者纳入5F导引导管组,共行146次手术,治疗231处病变。AHA B2/C型病变比例在两组间差异无统计学意义(5F组43.7%/29.0%比6F组46.1%/34.6%,P>0.05),但慢性闭塞性病变、分叉病变、钙化病变5F组显著少于6F组(5.6%比14.6%,P=0.005;23.4%比37.1%,P=0.012;9.5%比47.2%,P<0.001);组间的手术时间[(45±21)min比(46±19)min)]、手术X线曝光时间[(15±12)min比(16±13)min]、使用造影剂量[(140±45)ml比(156±56)ml]差异均无显著统计学意义(P>0.05),但是5F组造影剂用量有减少的趋势(P=0.066);组间住院时间[(1.40±1.26)d比(1.29±0.69)d]和手术成功率(95.2%比94.6%)也差异无统计学意义(P>0.05);5F组1例患者术后桡动脉闭塞,6F组无患者术后桡动脉闭塞(P=1.0),5F组1例发生卒中。结论经桡动脉冠状动脉介入治疗,即使是复杂及高危冠脉病变,5F导引导管有效、安全,手术成功率不低于常规使用的6F导引导管;换用5F导引导管进行冠状动脉介入治疗是一种有吸引力的选择。 | 刘兵 Paul TL Chiam Victor YT Lim | 2011 | 中国心血管杂志2011，16，3： | 5 |
| 11 | 中国孕晚期孕妇焦虑发生率与危险因素显示文摘许多研究表明,孕期母亲的心理精神问题与胎儿的不良结局相关。但是中国孕妇心理健康相关研究不多。为了调查孕期焦虑和相关因素,为有效降低孕期焦虑提供科学依据,2015年1—3月在中国长春市妇产医院开展了一项由467名孕期在38周以上孕妇参与的横截面研究。 | Kang YT Yao Y DOU J 张继 | 2017 | 中华预防医学杂志2017，51，2： | 4 |
| 12 | C-reactive protein activates complement in infarcted human myocardium显示文摘 | Nijmeijer R Lagrand WK Lubbers YT | 2003 | Am J Pathol2003，163，1： | 3 |
| 13 | Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection显示文摘 | Teng YT Nguyen H Gao X | 2000 | J Clin Invest2000，106，6： | 2 |
| 14 | Hepatic adenylate energy charge levels in patients with hepatoma after hepatic artery embolization显示文摘HepaticadenylateenergychargelevelsinpatientswithhepatomaafterhepaticarteryembolizationLILi1,YANLuNan1,CHENXiaoLi1,LUWuShe... | Li, L Yan, LN Chen, XL Lu, WS Xie, XD Wu, YT | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 15 | Physical activity in adolescence and young adulthood and breast cancer risk:a quantitative review显示文摘 | Lagerros YT Hsieh SF Hsieh CC | 2004 | Eur J Cancer Prev2004，13，1： | 2 |
| 16 | Characterization of cis-acting sequences regtflating root-specific gene expression in to- bacco 显示文摘 | Yamamoto YT Taylor CG Acedo GN | 1991 | Plant Cell1991，3，： | 1 |
| 17 | A testicular antigen aberrantly expressed in human cancers detected by autologous screening显示文摘 | YT Chen Scanlan MJ | 1997 | Proc Natl Acad Sci USA1997，94，5： | 1 |
| 18 | Bax translocates from cytosol to mitochondria incardiac cells during apoptosis:development of a GFP-Bax-stable H9c2 cell line for apoptosis analysis显示文摘 | Hou Q Hsu YT | 2005 | Am J Physiol Heart Circ Physiol2005，289，1： | 1 |
| 19 | A study of PVRL1 mutations for non-syndromic cleft lip and/or palate among Taiwanese patients显示文摘 | Tseng YT Hsiao HH Hsiao HP | 2006 | J Oral Maxillofac Surg2006，35，5： | 1 |
| 20 | Overview of Chinese research on senile dementia in mainland China显示文摘 | Song YT Wang JT | 2010 | Ageing Res Rev2010，9，1： | 1 |
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