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	题名	作者	年代	出处	被引量
1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
2	Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes显示文摘	Poon TC Yip TT Chan AT	2003	Clin Chem2003，49，：	1
3	A magnetic bead-based serum proteomic fingerprinting method for parallel analytical analysis and micropreparative purification 显示文摘	Wong MY Yu KO Poon TC	2010	Electrophoresis2010，31，10：	1
4	High-throughput quantitative profiling of serum N-glycome by MALDI-TOF mass spectrometry and N-glycomic fingerprint of liver fibrosis显示文摘	KAM RK POON TC CHAN HL	2007	Clin Chem2007，53，7：	1
5	Diagnosis of gastric cancer by serum proteomic Fingerprinting 显示文摘	Poon TC Sung JJ Chow SM	2006	Gastroenterology2006，130，6：	1
6	Quantification and utility of monosialylated alpha-fetoprotein in the diagnosis of hepatocellular carcinoma with nondiagnosfic serum total alpha-fetoprotein 显示文摘	Poon TC Mok TS Chart AT	2002	Clin Chem2002，48，7：	1
7	Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes显示文摘	Poon TC Yip TT Chan AT	2003	Clin Chem2003，49，5：	1
8	Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preecclampsia 显示文摘	Wang CC Yim KW Poon TC	2007	Clin Chem2007，53，：	1
9	Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes 显示文摘	Poon TC Yip TY Chan AT	2003	Clin Chem2003，49，5：	1
10	Proteome analysis and its impact on the discovery of serological tumor markers显示文摘	Poon TC Johnson PJ	2001	Clinica Chemical Acta2001，313，：	1
11	Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic Fingerprinting: a pilot study显示文摘	Poon TC Hui AY Chan HL	2005	Clin Chem2005，51，2：	1
12	显示文摘	Poon TC Yip TT Chan AT	2003	Clin Chem2003，49，5：	1
13	Proteome analysis and its impact on the discovery of serological tumor makers显示文摘	Poon TC Johnson PJ	2001	Clin Chim Acta2001，313，：	1
14	Prognostic sign/ficance of tumor angiogenesis,Ki67,p53 oncopmtein,epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal careinoma-a prospective study显示文摘	Ma BB Poon TC To KF	2003	Head NeeK2003，25，10：	1
15	Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting:a pilot study显示文摘	Poon TC Hui AY Chan HL	2005	Clin Chem2005，51，2：	1
16	Antitumor effect and enhance- ment of eytotoxic drug activity by cetuximab in nasopharyngeal carcinomacells 显示文摘	Sung FL Poon TC Hui EP	2005	In Vivo2005，19，1：	1
17	Proteome analysis and its impact on the discovery of serological tumor markers显示文摘	Poon TC Johnson PJ	2001	Clin Chem Acta2001，313，12：	1
18	Quantification and utility of monosialylated alpha-fetoprotein in the diagnosis of hepatocellular carcinoma with nondiagnostic serum total alpha-fetoprotein 显示文摘	Poon TC Mok TS Chan AT	2002	Clin Chem2002，48，7：	1
19	Comprehensive proteomie profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes 显示文摘	Poon TC Yip TT Chan AT	2003	Clin Chem2003，49，5：	1
20	Opportunities and limitations of SELDI-TOF-MS in biomedical research : practical advices 显示文摘	Poon TC	2007	Expert Rev Proteomics2007，4，51：	1

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