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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | Suppression of Astroglial Scar Formation and Enhanced Axonal Regeneration Associated with Functional Recovery in a Spinal Cord Injury Rat Model by the Cell Cycle Inhibitor Olomoucine显示文摘Objective:To determine if a cell cycle inhibitior, olomoucine, would decrease neuronal cell death, limit astroglial proliferation and production of inhibitory CSPGs, and eventually enhance the functional compensation after SCI in rats. Methods: Three were used as un-operated controls and twelve as sham operated controls. Following spinal cord injury, 48 rats were randomly and blindly assigned to either olomoucine (n=24) or vehicle treatment (n=24) groups. Results: Up-regulations of cell cycle components were closely associated with neuronal cell death and astroglial proliferation as well as the production of CSPGs after SCI. Meanwhile, administration of olomoucine, a selective cell cycle kinase (CDK) inhibitor, has remarkably reduced the up-regulated cell cycle proteins and then decreased neuronal cell death, astroglial proliferation as well as accumulation of CSPGs. More importantly, the treatment with olomoucine has also increased expression of growth-associated proteins-43 (GAP-43), reduced the cavity formation, and improved functional deficits. Conclusion: Suppressing astroglial cell cycle in acute spinal cord injuries is beneficial to axonal growth. in turn, the future therapeutic strategies can be designed to achieve efficient axonal regeneration and functional compensation after traumatic CNS injury. | 宋宇锋 YU Zhi-yuan XIE Min-jie BU Bi-tao WITTE OW WANG Wei | 2006 | 神经损伤与功能重建2006，1，2： | 21 |
| 3 | Reduction of Cd in Rice through Expression of OXS3-like Gene Fragments显示文摘 | Wang, Changhu Guo, Weili Ye, Shan Wei, Pengcheng Ow, David W. | 2016 | Molecular Plant2016，9，2： | 5 |
| 4 | 虚拟品牌社区组织差异性和顾客契合对价值共创的影响显示文摘本文抓取MIUI社区的俱乐部用户信息和发布内容,构建多层线性模型,从行为、情感维度探究顾客契合对价值共创行为的影响,并讨论组织差异性的调节作用,旨在探究虚拟品牌社区顾客契合和组织差异性对企业和顾客价值共创的影响。研究结果表明:顾客行为契合对其在虚拟社区中的价值共创行为有促进作用,这种积极影响随着组织知识差异性的升高而减弱。组织知识差异性与个体价值共创行为正相关。顾客情感契合对其价值共创行为有抑制作用,这种消极影响随着组织情感差异性的提高而减弱。最后提出:企业应当加强与顾客的互动,提高顾客行为契合;协助构建知识多元化、情感契合协同的社群;优化社区信息环境,引导价值共创行为。 | 梁苑 Ow Terence | 2019 | 企业经济2019，38，3： | 4 |
| 5 | Identification of crystal symmetry from noisy diffraction patterns by a shape analysis and deep learning显示文摘The robust and automated determination of crystal symmetry is of utmost importance in material characterization and analysis.Recent studies have shown that deep learning(DL)methods can effectively reveal the correlations between X-ray or electron-beam diffraction patterns and crystal symmetry.Despite their promise,most of these studies have been limited to identifying relatively few classes into which a target material may be grouped.On the other hand,the DL-based identification of crystal symmetry suffers from a drastic drop in accuracy for problems involving classification into tens or hundreds of symmetry classes(e.g.,up to 230 space groups),severely limiting its practical usage. | Leslie Ching Ow Tiong Jeongrae Kim Sang Soo Han Donghun Kim | 2020 | npj Computational Materials2020，，1： | 2 |
| 6 | Gene transfers with subsequent removal of the selection gene from the host genome显示文摘 | Dale E C Ow D W | 1991 | Proc Natl Acad Sci USA1991，88，10： | 2 |
| 7 | Spontaneous cervical cephalic artez'ial dissection and its residuum: angiographic spectrum显示文摘 | Houser OW Mokri B Sundt TM | 1984 | AJNR1984，5，： | 1 |
| 8 | Relationship among histoligic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver sample 显示文摘 | Vuppalanchi R Cummings OW Saxena R | 2007 | J Clin Gastroenterol2007，41，2： | 1 |
| 9 | Intra- and intermolecular site-specific recombination in plant cells mediated by bacteriophage P1 recombinase 显示文摘 | Dale E C Ow D W | 1990 | Gene1990，91，1： | 1 |
| 10 | A comparison of prognostic tumor markers obtained on image-guided breast biopsies and final surgical specimens显示文摘 | Tawfik OW Joyce AJ | 2000 | Am J Surg2000，184，： | 1 |
| 11 | Determinants of adher- ence to highly active antiretroviral therapy in Chinese HIV/AIDS patients显示文摘 | Fong Ow Ho CF Fung LY | 2003 | HIV Med2003，4，2： | 1 |
| 12 | Pivotal study of iodine I131 tositumomab for chemotherapy-refractory low-grade or transformedlow-grade B-cell non-Hodgkin's lymphomas显示文摘 | Kaminski MS Zelenetz AD Press OW | 2001 | J Clin Oncol2001，19，19： | 1 |
| 13 | Long-term anticonvulsant therapy leads to low bone mineral density-evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells显示文摘 | Feldkamp J Becker A Witte OW | 2000 | Exp Clin Endocrinol Diabetes2000，108，1： | 1 |
| 14 | Acute regulation of proximal tubule apical membrane Na + /H^+ exchanger NHE-3: role of phosphorylation , protein trafficking ,and regulatory factors显示文摘 | Moe OW | 1999 | J Am Soc Nephrol1999，10，： | 1 |
| 15 | Novel insights into the pathogensis of uric acid nephrolithiasis显示文摘 | Maalouf NM Cameron MA Moe OW | 2004 | Curr Opin Nephrol Hypertens2004，13，2： | 1 |
| 16 | Platelet activation and function after trauma 显示文摘 | Jacoby RC Owings JT Holmes J | 2001 | J Trauma2001，51，4： | 1 |
| 17 | Irbesartan does not affect the pharmacokinetics of simvastatin in healthy subjects显示文摘 | Marino MR Vachharajami NN Hadjilambris OW | 2000 | J Clin Pharmacol2000，40，8： | 1 |
| 18 | Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura 显示文摘 | Braendstrup P Bjerrum OW Nielsen OJ | 2005 | Am J Hematol2005，78，4： | 1 |
| 19 | Temporal profile of connexin 43 expression after photothrombotic lesion in rat brain 显示文摘 | Haupt C Witte OW Frahm C | 2007 | Neuroscience2007，144，： | 1 |
| 20 | Hope among terminally ill patients in Singapore: all exploratory study 显示文摘 | Hong IW Ow R | 2007 | Soc Work Health Care2007，45，3： | 1 |
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