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| 1 | Thermal energy storage:Challenges and the role of particle technology显示文摘Thermal energy is at the heart of the whole energy chain providing a main linkage between the primary and secondary energy sources.Thermal energy storage(TES)has a pivotal role to play in the energy chain and hence in future low carbon economy.However,a competitive TES technology requires a number of scientific and technological challenges to be addressed including TES materials,TES components and devices,and integration of TES devices with energy networks and associated dynamic optimization.This paper provides a perspective of TES technology with a focus on TES materials challenges using molten salts based phase change materials for medium and high temperature applications.Two key challenges for the molten salt based TES materials are chemical incompatibility and low thermal conductivity.The use of composite materials provides an avenue to meeting the challenges.Such composite materials consist of a phase change material,a structural supporting material,and a thermal conductivity enhancement material.The properties of the supporting material could determine the dispersion of the thermal conductivity enhancement material in the salt.A right combination of the salt,the structural supporting material,and the thermal conductivity enhancement material could give a hierarchical structure that is able to encapsulate the molten salt and give a substantial enhancement in the thermal conductivity.Understanding of the structure-property relationships for the composite is essential for the formulation design and fabrication of the composite materials.Linking materials properties to the system level performance is recommended as a key future direction of research. | Zhiwei Ge Yongliang Li Dacheng Li Ze Sun Yi Jin Chuanping Liu Chuan Li Guanghui Leng Yulong Ding | 2014 | Particuology2014，12，4： | 20 |
| 2 | Jianpijiedu Fang improves survival of hepatocarcinoma mice by affecting phosphatase and tensin homolog, phosphoinositide 3-kinase, and focal adhesion kinase显示文摘OBJECTIVE: To investigate the effect of Jianpijiedu Fang (JPJDF) on phosphatase and tensin homolog (PTEN), phosphoinositide 3-kinase (PI3K), and focal adhesion kinase (FAK), and on the survival of hepatocellular carcinoma (HCC) nude mice. METHODS: Forty male nude mice were randomly divided into 4 groups. Human HCC tissue was implanted in the livers of three groups. After 24 h, the three groups were treated respectively with JPJDF (37.5 g/kg), saline (20 mL/kg) and Tegafur (FT-207, 160 mg/kg) once a day for 10 weeks. The control group without implanting the tissue was concurrently treated with saline (20 mL/kg). The survival data and body weight of all mice were recorded, and expression levels of PTEN, PI3K and FAK in normal tissue and cancer tissue of the livers were eval-uated with immunohistochemical method. RESULTS: The cumulative survival rate of the mice in the JPJDF group was higher than those of the other groups. The rate of weight loss was the lowest in JPJDF group. The survivability and weight loss rate in FT-207 group were the poorest in all groups. The expression intensity of PTEN was higher in normal tissues than in cancer tissues, and lower in the normal tissues of HCC models than in that of mice without HCC. The PTEN expression intensity in normal tissue and cancer tissue from mice treated with FT-207 were lower than that from the mice treated with JPJDF or saline.The expression intensity of PI3K was higher in cancer tissue than in normal tissue. The PI3K expression intensity was the lowest in normal tissue and cancer tissue from mice treated with JPJDF, and the intensity from mice treated with FT-207 was the highest. In mice treated with JPJDF, the expression intensity of FAK was higher in the normal tissue and lower in the cancer tissue than those of the other treatment groups. CONCLUSION: The mechanism accounting for the prolonged survival of HCC-bearing mice treated with JPJDF might be related to the reduction in weight loss and the benign regulation of PTEN, PI3K, and FAK. | Baoguo Sun Jun Meng Ting Xiang Zexiong Chen Yulong Li Lisha Lu Shijun Zhang Xiaolin Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 12 |
| 3 | High-performance PVDF-HFP based gel polymer electrolyte with a safe solvent in Li metal polymer battery显示文摘Poly(vinylidenefluoride-co-hexafluoropropylene)(PVDF-HFP)based gel polymer electrolytes are widely studied owing to their electrochemical stability and high dielectric constant.However,most gel polymer electrolytes show unsatisfied safety and interface compatibility due to excessive absorption of volatile and flammable liquid solvents.Herein,by using a safe solvent(N-methyl-2-pyrrolidone)with higher boiling(203℃)and flash points(95℃),we initiatively fabricate a flexible PVDF-HFP based gel polymer electrolyte.The obtained gel polymer electrolyte demonstrates a high ionic conductivity of 7.24×10^−4 S cm−1,an electrochemical window of 5.2 V,and a high lithium transference number of 0.57.As a result,the synthesized polymer electrolyte exhibits a capacity retention of 70%after 500 cycles at 0.5 C,and a discharge capacity of 86 mAh g−1 even at a high current rate of 10 C for LiFePO4 based Li metal batteries.Moreover,a stable Li plating/stripping for more than 500 h is achieved under 0.1 mAh at both room temperature and 70℃.Our results indicate that the PVDF-HFP polymer electrolyte is promising for manufacturing safe and high-performance Li metal polymer batteries. | Jing Jie Yulong Liu Lina Cong Bohao Zhang Wei Lu Xinming Zhang Jun Liu Haiming Xie Liqun Sun | 2020 | Journal of Energy Chemistry2020，29，10： | 10 |
| 4 | The status of exploitation techniques of natural gas hydrate显示文摘Natural gas hydrate(NGH)has been widely considered as an alternative form of energy with huge potential,due to its tremendous reserves,cleanness and high energy density.Several countries involving Japan,Canada,India and China have launched national projects on the exploration and exploitation of gas hydrate resources.At the beginning of this century,an early trial production of hydrate resources was carried out in Mallik permafrost region,Canada.Japan has conducted the first field test from marine hydrates in 2013,followed by another trial in 2017.China also made its first trial production from marine hydrate sediments in 2017.Yet the low production efficiency,ice/hydrate regeneration,and sand problems are still commonly encountered;the worldwide progress is far before commercialization.Up to now,many gas production techniques have been proposed,and a few of them have been adopted in the field production tests.Nevertheless,hardly any method appears really promising;each of them shows limitations at certain conditions.Therefore,further efforts should be made on the economic efficiency as well as sustainability and environmental impacts.In this paper,the investigations on NGH exploitation techniques are comprehensively reviewed,involving depressurization,thermal stimulation,chemical inhibitor injection,CO2–CH4 exchange,their combinations,and some novel techniques.The behavior of each method and its further potential in the field test are discussed.The advantages and limitations of laboratory studies are also analyzed.The work could give some guidance in the future formulation of exploitation scheme and evaluation of gas production behavior from hydrate reservoirs. | Lei Yang Yulong Liu Hanquan Zhang Bo Xiao Xianwei Guo Rupeng Wei Lei Xu Lingjie Sun Bin Yu Shudong Leng Yanghui Li | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 9 |
| 5 | Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis显示文摘The occurrence of osteoarthritis(OA)is highly associated with the reduced lubrication property of the joint,where a progressive and irreversible damage of the articular cartilage and consecutive inflammatory response dominate the mechanism.In this study,bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel,we successfully developed injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment.Particularly,the lubricating microspheres(GelMA@DMA-MPC)were fabricated by dip coating a self-adhesive polymer(DMA-MPC,synthesized by free radical copolymerization)on superficial surface of photo-crosslinked methacrylate gelatin hydrogel microspheres(GelMA,prepared via microfluidic technology),and encapsulated with an anti-inflammatory drug of diclofenac sodium(DS)to achieve the dual-functional performance.The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the GelMA@DMA-MPC microspheres.In addition,the functionalized microspheres were intra-articularly injected into the rat knee joint with an OA model,and the biological tests including qRT-PCR,immunofluorescence staining assay,X-ray radiography and histological staining assay all revealed that the biocompatible microspheres provided significant therapeutic effect against the development of OA.In summary,the injectable hydrogel microspheres developed herein greatly improved lubrication and achieved sustained local drug release,therefore representing a facile and promising technique for the treatment of OA. | Ying Han Jielai Yang Weiwei Zhao Haimang Wang Yulong Sun Yuji Chen Jing Luo Lianfu Deng Xiangyang Xu Wenguo Cui Hongyu Zhang | 2021 | Bioactive Materials2021，6，10： | 8 |
| 6 | The 2020 Summer Floods and 2020/21 Winter Extreme Cold Surges in China and the 2020 Typhoon Season in the Western North Pacific显示文摘China experienced significant flooding in the summer of 2020 and multiple extreme cold surges during the winter of 2020/21.Additionally,the 2020 typhoon season had below average activity with especially quiet activity during the first half of the season in the western North Pacific(WNP).Sea surface temperature changes in the Pacific,Indian,and Atlantic Oceans all contributed to the heavy rainfall in China,but the Atlantic and Indian Oceans seem to have played dominant roles.Enhancement and movement of the Siberian High caused a wavier pattern in the jet stream that allowed cold polar air to reach southward,inducing cold surges in China.Large vertical wind shear and low humidity in the WNP were responsible for fewer typhoons in the first half of the typhoon season.Although it is known that global warming can increase the frequency of extreme weather and climate events,its influences on individual events still need to be quantified.Additionally,the extreme cold surge during 16–18 February 2021 in the United States shares similar mechanisms with the winter 2020/21 extreme cold surges in China. | Chunzai WANG Yulong YAO Haili WANG Xiubao SUN Jiayu ZHENG | 2021 | Advances in Atmospheric Sciences2021，38，6： | 8 |
| 7 | Genetic-algorithm-based deep neural networks for highly efficient photonic device design显示文摘While deep learning has demonstrated tremendous potential for photonic device design,it often demands a large amount of labeled data to train these deep neural network models.Preparing these data requires high-resolution numerical simulations or experimental measurements and cost significant,if not prohibitive,time and resources.In this work,we present a highly efficient inverse design method that combines deep neural networks with a genetic algorithm to optimize the geometry of photonic devices in the polar coordinate system.The method requires significantly less training data compared with previous inverse design methods.We implement this method to design several ultra-compact silicon photonics devices with challenging properties including power splitters with uncommon splitting ratios,a TE mode converter,and a broadband power splitter.These devices are free of the features beyond the capability of photolithography and generally in compliance with silicon photonics fabrication design rules. | YANGMING REN LINGXUAN ZHANG WEIQIANG WANG XINYU WANG YUFANG LEI YULONG XUE XIAOCHEN SUN WENFU ZHANG | 2021 | Photonics Research2021，9，6： | 6 |
| 8 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 9 | Accelerated Aging Experiment and Remaining Lifetime Analysis of Insulation for CXF Type Cable on Vessels显示文摘 | WANG Hexun JI Yulong LIU Gaishi GUO Yang SUN Yuqing | 2013 | 高电压技术2013，39，8： | 4 |
| 10 | Study on Quantitative Relationship between Surface Wettability and Frictional Coefficient of Liquid Flowing in a Turbulent Horizontal Pipe显示文摘This paper had investigated the effects of surface wettability on the frictional resistance of turbulent horizontal flow for tap water in five pipes made of various materials and four kinds of liquids in a polytetrafluoroethylene(PTFE) pipe,with the same inner diameter of 14 mm. Pressure drops were measured under different flow rates through an experimental flow loop. The contact angles and adhesion work of liquids in contact with pipe surfaces were determined using a contact angle meter. Based on the dimension and regression analyses, two kinds of modified relationships between the frictional coefficient and the surface wettability were established according to the measured results corresponding to tap water in five pipes and four liquids in PTFE pipe. The experimental results show that the surface wettability has some influence on frictional coefficient of the studied liquids flowing in macroscale pipes, and the frictional coefficient decreases with the increase of the contact angle at the same Reynolds number. Meanwhile the effect of wettability on the hydrophobic surface is greater than that on the hydrophilic one. The frictional coefficients predicted by the modified formulas have verified to be in good agreement with the experimental values, the relative errors of which are within ±6% and ±3% for the tap water flowing in five different pipes and four kinds of liquids flowing in PTFE pipe, respectively. | Jing Jiaqiang Qi Hongyuan Jiang Huayi Liang Aiguo Shi Jianying Wang Yulong Sun Nana Zhang Yixiang | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，3： | 4 |
| 11 | “Polymer-in-ceramic” based poly(ε-caprolactone)/ceramic composite electrolyte for all-solid-state batteries显示文摘Inspired by the concept of 'polymer-in-ceramic',a composite poly(ε-caprolactone)(PCL)/ceramic containing LiTFSI is prepared and investigated as a solid electrolyte for all-solid-state batteries.The composite with the optimum concentration of 45 wt% LiTFSI and 75 wt% Li1.5Al0.5Ge1.5(PO4)3(LAGP,NASICON-type structure) exhibits a high ionic conductivity(σi=0.17 mS cm-1) at 30℃,a transference number of 0.30,and is stable up to 5.0 V.The composite electrolyte is a flexible and self-standing membrane.Solid-state LiFePO4//Li batteries with this composite electrolyte demonstrate excellent cycling stability with high discharge capacity of 157 mA h g-1,high capacity retention of 96% and coulombic efficiency of 98.5% after 130 cycles at 30℃ and 0.1 C rate.These electrochemical properties are better than other PCL-based allsolid-lithium batteries,and validate the concept of 'polymer-in-ceramic' by avoiding the drawback of lower conductivity in prior 'polymer-in-ceramic' electrolyte at high concentration of the ceramic. | Bohao Zhang Yulong Liu Jia Liu Liqun Sun Lina Cong Fang Fu Alain Mauger Christian M.Julien Haiming Xie Xiumei Pan | 2021 | Journal of Energy Chemistry2021，30，1： | 4 |
| 12 | Distributed Information Flow Verification for Secure Service Composition in Smart Sensor Network显示文摘Accelerate processor, efficient software and pervasive connections provide sensor nodes with more powerful computation and storage ability, which can offer various services to user. Based on these atomic services, different sensor nodes can cooperate and compose with each other to complete more complicated tasks for user. However, because of the regional characteristic of sensor nodes, merging data with different sensitivities become a primary requirement to the composite services, and information flow security should be intensively considered during service composition. In order to mitigate the great cost caused by the complexity of modeling and the heavy load of single-node verification to the energy-limited sensor node, in this paper, we propose a new distributed verification framework to enforce information flow security on composite services of smart sensor network. We analyze the information flows in composite services and specify security constraints for each service participant. Then we propose an algorithm over the distributed verification framework involving each sensor node to participate in the composite service verification based on the security constraints. The experimental results indicate that our approach can reduce the cost of verification and provide a better load balance. | XI Ning SUN Cong MA Jianfeng CHEN Xiaofeng SHEN Yulong | 2016 | China Communications2016，13，4： | 3 |
| 13 | Effects of free-air CO_2 enrichment on adventitious root development of rice under low and normal soil nitrogen levels显示文摘Free air CO2 enrichment(FACE) and nitrogen(N) have marked effects on rice root growth,and numerical simulation can explain these effects. To further define the effects of FACE on root growth of rice, an experiment was performed, using the hybrid indica cultivar Xianyou63. The effects of increasing atmospheric CO2 concentration [CO2], 200 μmol mol-1higher than ambient, on the growth of rice adventitious roots were evaluated, with two levels of N: low(LN, 125 kg ha-1) and normal(NN, 250 kg ha-1). The results showed a significant increase in both adventitious root number(ARN) and adventitious root length(ARL) under FACE treatment. The application of nitrogen also increased ARN and ARL, but these increases were smaller than that under FACE treatment. On the basis of the FACE experiment, numerical models for rice adventitious root number and length were constructed with time as the driving factor. The models illustrated the dynamic development of rice adventitious root number and length after transplanting, regulated either by atmospheric [CO2] or by N application.The simulation result was supported by statistical tests comparing experimental data from different years, and the model yields realistic predictions of root growth. These results suggest that the models have strong predictive potential under conditions of atmospheric [CO2] rises in the future. | Chengming Sun Lijian Wang Tao Liu Doudou Guo Yingying Chen Wei Wu Yulong Wang Jianguo Zhu | 2014 | The Crop Journal2014，2，4： | 2 |
| 14 | Self-adhesive lubricated coating for enhanced bacterial resistance显示文摘Limited surface lubrication and bacterial biofilm formation pose great challenges to biomedical implants.Although hydrophilic lubricated coatings and bacterial resistance coatings have been reported,the harsh and tedious synthesis greatly compromises their application,and more importantly,the bacterial resistance property has seldom been investigated in combination with the lubrication property.In this study,bioinspired by the performances of mussel and articular cartilage,we successfully synthesized self-adhesive lubricated coating and simultaneously achieved optimal lubrication and bacterial resistance properties.Additionally,we reported the mechanism of bacterial resistance on the nanoscale by studying the adhesion interactions between biomimetic coating and hydrophilic/hydrophobic tip or living bacteria via atomic force microscopy.In summary,the self-adhesive lubricated coating can effectively enhance lubrication and bacterial resistance performances based on hydration lubrication and hydration repulsion,and represent a universal and facial strategy for surface functionalization of biomedical implants. | Ying Han Weiwei Zhao Yiwei Zheng Haimang Wang Yulong Sun Yifei Zhang Jing Luo Hongyu Zhang | 2021 | Bioactive Materials2021，6，8： | 2 |
| 15 | Li4-xSbxSn1-xS4 solid solutions for air-stable solid electrolytes显示文摘The sulfide solid electrolytes have the characteristics of high ionic conductivity and low grain boundary resistance, which make them suitable for bulk-type all-solid-state batteries. However, most of them suffer from poor stability in air. Here, we explore the air stable sulfide solid electrolytes in Li4-xSbxSn1-xS4 system. The solid solutions of Li4-xSbxSn1-xS4(0 ≤ x ≤ 0.5) can be formed in Li4-xSbxSn1-xS4 system. Li3.8 Sb0.2 Sn0.8 S4 achieves the highest ionic conductivity of 3.5 × 10-4 S cm-1 in this system,which is 5 times as that of Li4 Sn S4 and 3 orders of magnitude higher than that of Li3 Sb S4, respectively. Li3.8 Sb0.2 Sn0.8 S4 crystallizes into the same structure with high ionic conductivity phase of β-Li3 PS4. Moreover, Li3.8 Sb0.2 Sn0.8 S4 owns good stability in humid air. Matching with LiCoO2 and Li4 Ti5 O12,Li3.8 Sb0.2 Sn0.8 S4 exhibits the potential to be applied in all-solid-state batteries. | Zhuoran Zhang Jianxing Zhang Yulong Sun Huanhuan Jia Linfeng Peng Yunyang Zhang Jia Xie | 2020 | Journal of Energy Chemistry2020，29，2： | 2 |
| 16 | Mitochondrion-targeted PENTATRICOPEPTIDE REPEAT5 is required for cis-splicing of nad4 intron 3 and endosperm development in rice显示文摘Endosperm as the storage organ of starch and protein in cereal crops largely determines grain yield and quality.Despite the fact that several pentatricopeptide repeat(PPR)proteins required for endosperm development have been identified in rice,the molecular mechanisms of many P-type PPR proteins in endosperm development remains unclear.Here,we isolated a rice floury endosperm mutant ppr5 that developed small starch grains and an abnormal aleurone layer,accompanied by decreased starch,protein,and amylose contents.Map-based cloning combined with a complementation test demonstrated that PPR5 encodes a P-type PPR protein that is localized to the mitochondria.The mutation in PPR5 caused reduced splicing efficiency of mitochondrial NADH dehydrogenase 4(nad4)gene intron 3 and reduced complex I assembly and activity.Loss of PPR5 function greatly upregulated expression of alternative oxidases(AOXs),reduced ATP production,and affected mitochondrial morphology.We demonstrate that PPR5,as a P-type PPR protein,is required for mitochondrial function and endosperm development by controlling the cis-splicing of mitochondrial nad4 intron 3. | Long Zhang Yanzhou Qi Mingming Wu Lei Zhao Zhichao Zhao Cailin Lei Yuanyuan Hao Xiaowen Yu Yinglun Sun Xin Zhang Xiuping Guo Yulong Ren Jianmin Wan | 2021 | The Crop Journal2021，9，2： | 2 |
| 17 | Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer显示文摘Oxaliplatin is widely used in the frontline treatment of colorectal cancer(CRC),but an estimated 50%of patients will eventually stop responding to treatment due to acquired resistance.This study revealed that diminished MEIS1 expression was detected in CRC and harmed the survival of CRC patients.MEIS1 impaired CRC cell viabilities and tumor growth in mice and enhanced CRC cell sensitivity to oxaliplatin by preventing DNA damage repair.Mechanistically,oxaliplatin resistance following MEIS1 suppression was critically dependent on enhanced FEN1 expression.Subsequently,we confirmed that EZH2-DNMT3a was assisted by lncRNA ELFN1-AS1 in locating the promoter of MEIS1 to suppress MEIS1 transcription epigenetically.Based on the above,therapeutics targeting the role of MEIS1 in oxaliplatin resistance were developed and our results suggested that the combination of oxaliplatin with either ELFN1-AS1 ASO or EZH2 inhibitor GSK126 could largely suppress tumor growth and reverse oxaliplatin resistance.This study highlights the potential of therapeutics targeting ELFN1-AS1 and EZH2 in cell survival and oxaliplatin resistance,based on their controlling of MEIS1 expression,which deserve further verification as a prospective therapeutic strategy. | Yimin Li Yaqi Gan Jiaxin Liu Juanni Li Zhengwei Zhou Ruotong Tian Ruizheng Sun Jiaqi Liu Qing Xiao Yuanyuan Li Pengyan Lu Yulong Peng Yuqian Peng Guang Shu Gang Yin | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 18 | Surface wettability and flow properties of non-metallic pipes in laminar flow显示文摘In this paper,three liquids flowing in five pipes with the same inner diameter of 14 mm were studied to determine the relationship between the surface wettability and flow properties in laminar flow(Re b 2000).This was motivated by oilfield observations of increased pressure drops in non-metallic pipes compared to those in metal pipes,which was contrary to expectations.A new expression for the frictional coefficient that considers the Reynolds number and contact angleθin laminar flow for non-metallic pipes was proposed based on the experimental results of single-phase flow using dimension and regression analyses.The solutions of the anomalous phenomenon were proposed from the perspectives of the pipe diameter,contact-angle difference,and the compatibility between flexible composite pipe and JLHW105 oil according to the new formula.The surprising finding was that the surface wettability could control the frictional resistance by the critical contact angle(39.9°)obtained at the same Reynolds number.If 0°bθ≤39.9°,the frictional coefficient increased as the contact angle increased.In contrast,if 39.9°bθb 180°,the frictional coefficient decreased with increasing contact angle.The influences of the pipe diameter and contactangle difference on the pressure drop difference of JLHW105 oil showed an inversely proportional relation.A series of materials and liquids were tested.The selection of pipe material for transporting a given fluid can be based on the contact angle,surface tension,and critical limit of the contact angle obtained.The research results are expected to provide some guidelines for the selection of the appropriate pipe material for a given set of fluids. | Hongyuan Qi Aiguo Liang Huayi Jiang Jianying Shi Nana Sun Yulong Wang | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 2 |
| 19 | The morphological identification of Protoperidinium(Peridiniales, Dinophyceae) species on the coasts of China显示文摘The classification and identification for Protoperidinium species are the most difficult work during its taxonomic study. In this research, taxonomic status of Protoperidinium was clarified by tracing its taxonomic history, 23 species belong to genus Protoperidinium on the coasts of China were preliminarily identified, and morphological description and plate patterns were given for each species. The key differences of similar species were also discussed in this study, we believe that P. oceanicum and P. murry, P. tumidum and P. fatulipes, P. globules and P.majus are separate species; P. diabolum should be treated as the valid name instead of the reported names Peridinium globosum or Peridinium longipes; the taxonomic relationship between P. punctulatum and P.subinerme requires further study. | LI Ruixiang PAN Yulong SUN Huiying LI Yan MA Xin WANG Yan | 2016 | Acta Oceanologica Sinica2016，35，4： | 2 |
| 20 | Rice FLOURY ENDOSPERM 18 encodes a pentatricopeptide repeat protein required for 5′ processing of mitochondrial nad5 messenger RNA and endosperm development显示文摘Pentatricopeptide repeat(PPR) proteins, composing one of the largest protein families in plants,are involved in RNA binding and regulation of organelle RNA metabolism at the posttranscriptional level. Although several PPR proteins have been implicated in endosperm development in rice(Oryza sativa), the molecular functions of many PPRs remain obscure. Here, we identified a rice endosperm mutant named floury endosperm 18(flo18) with pleiotropic defects in both reproductive and vegetative development.Map-based cloning and complementation tests showed that FLO18 encodes a mitochondriontargeted P-type PPR protein with 15 PPR motifs.Mitochondrial function was disrupted in the flo18 mutant, as evidenced by decreased assembly of Complex I in the mitochondrial electron transport chain and altered mitochondrial morphology. Loss of FLO18 function resulted in defective 5′-end processing of mitochondrial nad5 transcripts encoding subunit 5 of nicotinamide adenine dinucleotide hydrogenase. These results suggested that FLO18 is involved in 5′-end processing of nad5 messenger RNA and plays an important role in mitochondrial function and endosperm development. | Mingzhou Yu Mingming Wu Yulong Ren Yihua Wang Jingfang Li Cailin Lei Yinglun Sun Xiuhao Bao Hongming Wu Hang Yang Tian Pan Yongfei Wang Ruonan Jing Mengyuan Yan Houda Zhang Lei Zhao Zhichao Zhao Xin Zhang Xiuping Guo Zhijun Cheng Bing Yang Ling Jiang Jianmin Wan | 2021 | Journal of Integrative Plant Biology2021，63，5： | 2 |
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