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| 1 | Design and Experiment of PZT Network-based Structural Health Monitoring Scanning System显示文摘基于主动Lamb波和压电传感器网络的结构健康监测技术是一种评估航空结构健康状态的有效方法。在实际应用中,监测大型结构需要使用压电传感器网络。扫查这些压电传感器网络中的压电激励-传感通道以达到在线的结构健康监测是非常重要的。基于PXI(PCI eXtensions for Instrumentation)平台,研发了一套基于主动Lamb波和压电传感器网络的集成多通道扫查系统,该系统结构紧凑、便于携带,能大规模自动扫查激励-传感通道并进行损伤评估。提出和讨论了该系统中:4通道PXI程控增益电荷放大器的实现、支持276个激励-传感通道的外部扫查模块和集成的结构健康监测软件的实现。最后,主要讨论了系统在某型无人机碳纤维复合材料机翼盒段上的功能验证实验,包括:压电贴层的设计、激励信号频率的选择方法、损伤成像的功能性测试、系统稳定性测试和载荷对信号的影响。实验结果验证了该系统的稳定性和损伤监测功能。 | Qiu Lei Yuan Shenfang Wang Qiang Sun Yajie Yang Weiwei | 2009 | Chinese Journal of Aeronautics2009，22，5： | 23 |
| 2 | Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)has become one of the most prominent causes of chronic liver diseases and malignancies.However,few therapy has been approved.Radix Bupleuri(RB)is the most frequently used herbal medicine for the treatment of liver diseases.In the current study,we aim to systemically evaluate the therapeutic effects of saikosaponin A(SSa)and saikosaponin D(SSd),the major bioactive monomers in RB,against NAFLD and to investigate the underlying mechanisms.Our results demonstrated that both SSa and SSd improved diet-induced NAFLD.Integrative lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes,like Lipe and Lipg.SSd profoundly suppressed the fatty acid biosynthesis by downregulating Fasn and Acaca expression and promoted fatty acid degradation by inducing Acox1 and Cpt1 a expression.Bioinformatic analysis further predicted the implication of master transcription factors,including peroxisome proliferator-activated receptor alpha(PPARα),in the protective effects of SSa and SSd.These results were further confirmed in vitro in mouse primary hepatocytes.In summary,our study uncoded the complicated mechanisms underlying the promising anti-steatosis activities of saikosaponins(SSs),and provided critical evidence inspiring the discovery of innovative therapies based on SSa and SSd for the treatment of NAFLD and related complications. | Xiaojiaoyang Li Junde Ge Yajing Li Yajie Cai Qi Zheng Nana Huang Yiqing Gu Qi Han Yunqian Li Rong Sun Runping Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 3 | Phytoplankton communities and its controlling factors in summer and autumn in the southern Yellow Sea, China显示文摘The phytoplankton water samples were collected in two multidisciplinary investigations which were carried out during summer(June) and autumn(November to December) of 2011. Phytoplankton species composition and abundance data were accomplished by Uterm?hl method. The phytoplankton community was dominated by diatoms and dinoflagellates in the southern Yellow Sea(YS) in summer and autumn. In summer, Paralia sulcata and Prorocentrum dentatum were the predominated species, the cell abundance ranged from 0.074 to 107.733×103 cells/L with an average of 9.057×103 cells/L. Two phytoplankton high abundance appeared in northwest part of the survey area and the Changjiang River Estuary, respectively. In autumn, Par. sulcata became the predominant species, and the phytoplankton cell abundance ranged from 1.035×103 to 8.985×103 cells/L, the average was 3.263×103 cells/L. The phytoplankton abundance in surface layer presented the homogeneous distributions. Canonical Correspondence Analysis(CCA) method was applied for discovering the relationship between environmental factors and the common found phytoplankton species. The responses of phytoplankton to nutrients were varied between summer and autumn. The abundance of most predominant species, Par. sulcata was strongly correlated to temperature and salinity in autumn, but not the case in summer. | LIU Haijiao HUANG Yajie ZHAI Weidong GUO Shujin JIN Hualong SUN Jun | 2015 | Acta Oceanologica Sinica2015，34，2： | 8 |
| 4 | Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy显示文摘An essential concept of cancer immunotherapy is that immunogenic cell death(ICD),characterized by the release of tumor-associated antigens(TAAs)and tumor-specific antigens(TSAs)like neoantigens,danger-associated molecular patterns(DAMPs),and pro-inflammatory cytokines,facilitates the presentation of TAAs and TSAs to adaptive immune cells,eliciting an emerging or reinstating a pre-existing anti-cancer immune response. | Yajie Sun Xiangru Feng Chao Wan Jonathan F.Lovell Honglin Jin Jianxun Ding | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，2： | 5 |
| 5 | Selective hydrogenation of benzene to cyclohexene over Ce-promoted Ru catalysts显示文摘Ru-Ce catalysts were prepared by a co-precipitation method.The effects of Ce precursors with different valences and Ce contents on the catalytic performance of Ru-Ce catalysts were investigated in the presence of ZnSO4.The Ce species in the catalysts prepared with different valences of the Ce precursors all exist as CeO2 on the Ru surface.The promoter CeO2alone could not improve the selectivity to cyclohexene of Ru catalysts.However,almost all the CeO2 in the catalysts could react with the reaction modifier ZnSO4 to form(Zn(OH)2)3(ZnSO4)(H2O)3 salt.The amount of the chemisorbed salt increased with the CeO2 loading,resulting in the decrease of the activity and the increase of the selectivity to cyclohexene of Ru catalyst.The Ru-Ce catalyst with the optimum Ce/Ru molar ratio of 0.19 gave a maximum cyclohexene yield of 57.4%.Moreover,this catalyst had good stability and excellent reusability. | Haijie Sun Yajie Pan Shuaihui Li Yuanxin Zhang Yingying Dong Shouchang Liu Zhongyi Liu | 2013 | Journal of Energy Chemistry2013，22，5： | 4 |
| 6 | Mullite whiskers prepared by molten salt method using Si powders显示文摘Mullite whiskers were prepared from Si powders in molten Al2(SO4)3-Na2SO4 mixture salts with different Al/Si molar ratio(R)of raw materials.The resulting mullite whiskers,had been investigated using X-ray diffraction(XRD),scanning electron microscopy(SEM),energy dispersive spectrometer(EDS)and infrared spectroscopy analysis(FT-IR).Mullite phase was obtained in molten salts when the temperature reached at 850℃.SEM and EDS results revealed that two kinds of microstructures were formed in the final product,Al-rich mullite pellets and clusters of tiny mullite crystals,and the content of Al-rich mullite pellets increased with the higher Al/Si molar ratio(R)adopted in raw materials.A new oxidation-dissolution mechanism was proposed to explain mullite whiskers growth.According to thermodynamic analysis,mullite phase might be spontaneously formed as the temperature reached the decomposition temperature of aluminum sulfate(1023 K). | Wei WANG Hongwei LI Yajie GUO Qiang SUN Chen CHEN | 2012 | Journal of Advanced Ceramics2012，1，4： | 2 |
| 7 | Near-Term Projections of Global and Regional Land Mean Temperature Changes Considering Both the Secular Trend and Multidecadal Variability显示文摘Near-term climate projections are needed by policymakers; however, these projections are difficult because internally generated climate variations need to be considered. In this study, temperature change scenarios in the near-term period 2017-35 are projected at global and regional scales based on a refined multi-model ensemble approach that considers both the secular trend(ST) and multidecadal variability(MDV) in the Coupled Model Intercomparison Project Phase 5(CMIP5) simulations. The ST and MDV components are adaptively extracted from each model simulation by using the ensemble empirical mode decomposition(EEMD) filter, reconstructed via the Bayesian model averaging(BMA) method for the historical period 1901-2005, and validated for 2006-16. In the simulations of the 'medium' representative concentration pathways scenario during 2017-35, the MDV-modulated temperature change projected via the refined approach displays an increase of 0.44℃(90% uncertainty range from 0.30 to 0.58℃) for global land, 0.48℃(90% uncertainty range from 0.29 to 0.67℃) for the Northern Hemispheric land(NL), and 0.29℃(90% uncertainty range from 0.23 to 0.35℃) for the Southern Hemispheric land(SL). These increases are smaller than those projected by the conventional arithmetic mean approach. The MDV enhances the ST in 13 of 21 regions across the world. The largest MDV-modulated warming effect(46%) exists in central America. In contrast,the MDV counteracts the ST in NL, SL, and eight other regions, with the largest cooling effect(220%) in Alaska. | Yajie QI Zhongwei YAN Cheng QIAN Ying SUN | 2018 | Journal of Meteorological Research2018，32，3： | 2 |
| 8 | Cigarette smoke promotes oral leukoplakia via regulating glutamine metabolism and M2 polarization of macrophage显示文摘Oral immunosuppression caused by smoking creates a microenvironment to promote the occurrence and development of oral mucosa precancerous lesions.This study aimed to investigate the role of metabolism and macrophage polarization in cigarette-promoting oral leukoplakia.The effects of cigarette smoke extract(CSE)on macrophage polarization and metabolism were studied in vivo and in vitro.The polarity of macrophages was detected by flow cytometric analysis and q PCR.Liquid chromatography-mass spectrometry(LC-MS)was used to perform a metabolomic analysis of Raw cells stimulated with CSE.Immunofluorescence and flow cytometry were used to detect the polarity of macrophages in the condition of glutamine abundance and deficiency.Cell Counting Kit-8(CCK-8),wound-healing assay,and Annexin V-FITC(fluorescein isothiocyanate)/PI(propidium iodide)double-staining flow cytometry were applied to detect the growth and transferability and apoptosis of Leuk-1 cells in the supernatant of Raw cells which were stimulated with CSE,glutamine abundance and deficiency.Hyperkeratosis and dysplasia of the epithelium were evident in smoking mice.M2 macrophages increased under CSE stimulation in vivo and in vitro.In total,162 types of metabolites were detected in the CSE group.The metabolites of nicotine,glutamate,arachidic acid,and arginine changed significantly.The significant enrichment pathways were also selected,including nicotine addiction,glutamine and glutamate metabolism,and arginine biosynthesis.The results also showed that the supernatant of Raw cells stimulated by CSE could induce excessive proliferation of Leuk-1 and inhibit apoptosis.Glutamine abundance can facilitate this process.Cigarette smoke promotes oral leukoplakia via regulating glutamine metabolism and macrophage M2 polarization. | Yanan Zhu Shuo Zhang Jiahui Sun Tingting Wang Qin Liu Guanxi Wu Yajie Qian Weidong Yang Yong Wang Wenmei Wang | 2021 | International Journal of Oral Science2021，13，3： | 2 |
| 9 | In Vivo Two-photon Calcium Imaging in Dendrites of Rabies Virus-labeled V1 Corticothalamic Neurons显示文摘Monitoring neuronal activity in vivo is critical to understanding the physiological or pathological functions of the brain.Two-photon Ca^(2+)imaging in vivo using a cranial window and specific neuronal labeling enables realtime,in situ,and long-term imaging of the living brain.Here,we constructed a recombinant rabies virus containing the Ca^(2+)indicator GCaMP6 s along with the fluorescent protein DsRed2 as a baseline reference to ensure GCaMP6 s signal reliability.This functional tracer was applied to retrogradely label specific V1-thalamus circuits and detect spontaneous Ca^(2+)activity in the dendrites of V1 corticothalamic neurons by in vivo two-photon Ca^(2+)imaging.Notably,we were able to record single-spine spontaneous Ca2+activity in specific circuits.Distinct spontaneous Ca^(2+)dynamics in dendrites of V1 corticothalamic neurons were found for different V1-thalamus circuits.Our method can be applied to monitor Ca^(2+)dynamics in specific input circuits in vivo,and contribute to functional studies of defined neural circuits and the dissection of functional circuit connections. | Yajie Tang Liang Li Leqiang Sun Jinsong Yu Zhe Hu Kaiqi Lian Gang Cao Jinxia Dai | 2020 | Neuroscience Bulletin2020，36，5： | 2 |
| 10 | In vivo fiber photometry of neural activity in response to optogenetically manipulated inputs in freely moving mice显示文摘In vito fber photometry is a powerful technique to analyze the dy namics of population neurons during fiunctional study of neuroscience.Here,we introduced a detailed protocol for fiber photometry-based calciun reording in freely moving mice,covering from virus injection,fiber stub insertion,optogenetical stimulation to data procurement and analysis.Furthemnore,we applied this protocol to explore neuronal activity of mice latenal-posterior(LP)thalaric nucleus in response to optogenetical stimulation of primary visual cortex(V1)neurons,and explore axon clusters activity of optogenetically evoked V1 neurons.Final confirmation of virus-based protein expression in V1 and precise fber insertion indicated that the surgery procedure of this protocol is reliable for functional calcium recording.The scripts for data analysis and some tips in our protocol are provided in details.Together,this protocol is simple,low-cost,and effective for neuronal activity detection by fiber photometry,which will hep neuroscience researchers to carry out fiunctional and behavioral study in vivo. | Liang Li Yajie Tang Leqiang Sun Khaista Rahman Kai Huang Weize Xu Jinsong Yu Jinxia Dai Gang Cao | 2017 | Journal of Innovative Optical Health Sciences2017，，5： | 1 |
| 11 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 12 | Accelerated testing for automated vehicles safety evaluation in cut-in scenarios based on importance sampling,genetic algorithm and simulation applications显示文摘Purpose–It would take billions of miles’field road testing to demonstrate that the safety of automated vehicle is statistically significantly higher than the safety of human driving because that the accident of vehicle is rare event.Design/methodology/approach–This paper proposes an accelerated testing method for automated vehicles safety evaluation based on improved importance sampling(IS)techniques.Taking the typical cut-in scenario as example,the proposed method extracts the critical variables of the scenario.Then,the distributions of critical variables are statistically fitted.The genetic algorithm is used to calculate the optimal IS parameters by solving an optimization problem.Considering the error of distribution fitting,the result is modified so that it can accurately reveal the safety benefits of automated vehicles in the real world.Findings–Based on the naturalistic driving data in Shanghai,the proposed method is validated by simulation.The result shows that compared with the existing methods,the proposed method improves the test efficiency by 35 per cent,and the accuracy of accelerated test result is increased by 23 per cent.Originality/value–This paper has three contributions.First,the genetic algorithm is used to calculate IS parameters,which improves the efficiency of test.Second,the result of test is modified by the error correction parameter,which improves the accuracy of test result.Third,typical high-risk cut-in scenarios in China are analyzed,and the proposed method is validated by simulation. | Yiming Xu Yajie Zou Jian Sun | 2018 | Journal of Intelligent and Connected Vehicles2018，1，1： | 1 |
| 13 | Morphology and mechanical properties of polypropylene/calcium carbonate nanocomposites 显示文摘 | Yang Kun Yang Qi Li Guangxian Sun Yajie Feng Decai | 2006 | Materials Letters2006，60，6： | 1 |
| 14 | Inactivated Pseudomonas PE(△Ⅲ)exotoxin fused to neutralizing epitopes of PEDV S proteins produces a specific immune response in mice显示文摘Porcine epidemic diarrhea(PED)caused by the porcine epidemic diarrhea virus(PEDV),is a severe infectious and devastating swine disease that leads to serious economic losses in the swine industry worldwide.An increased number of PED cases caused by variant PEDV have been reported in many countries since 2010.S protein is the main immunogenic protein containing some B-cell epitopes that can induce neutralizing antibodies of PEDV.In this study,the construction,expression and purification of Pseudomonas aeruginosa exotoxin A(PE)without domain Ⅲ(PE△Ⅲ)as a vector was performed for the delivery of PEDV S-A or S-B.PE(△Ⅲ)PEDV S-A and PE(△Ⅲ)PEDV S-B recombinant proteins were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis.The immunogenicity of PEDV S-A and PEDV S-B subunit vaccines were evaluated in mice.The results showed that PEDV-S-B vaccine could not only induce specific humoral and Th1 type-dominant cellular immune responses,but also stimulate PEDV-specific mucosal immune responses in mice.PEDV-S-B subunit vaccine is a novel candidate mucosal vaccine against PEDV infection. | Leqiang Sun Yajie Tang Keji Yan Huanchun Chen Huawei Zhang | 2021 | Animal Diseases2021，1，3： | 1 |
| 15 | Atomically Dispersed Fe-N_4 Modified with Precisely Located S for Highly Efficient Oxygen Reduction显示文摘Immobilizing metal atoms by multiple nitrogen atoms has triggered exceptional catalytic activity toward many critical electrochemical reactions due to their merits of highly unsaturated coordination and strong metal-substrate interaction.Herein,atomically dispersed Fe-NC material with precise sulfur modification to Fe periphery(termed as Fe-NSC) was synthesized,X-ray absorption near edge structure analysis confirmed the central Fe atom being stabilized in a specific configuration of Fe(N3)(N-C-S).By enabling precisely localized S doping,the electronic structure of Fe-N4 moiety could be mediated,leading to the beneficial adjustment of absorption/desorption properties of reactant/intermediate on Fe center.Density functional theory simulation suggested that more negative charge density would be localized over Fe-N4 moiety after S doping,allowing weakened binding capability to *OH intermediates and faster charge transfer from Fe center to O species.Electrochemical measurements revealed that the Fe-NSC sample exhibited significantly enhanced oxygen reduction reaction performance compared to the S-free Fe-NC material(termed as Fe-NC),showing an excellent onset potential of 1.09 V and half-wave potential of 0.92 V in 0.1 M KOH.Our work may enlighten relevant studies regarding to accessing improvement on the catalytic performance of atomically dispersed M-NC materials by managing precisely tuned local environments of M-Nx moiety. | Yin Jia Xuya Xiong Danni Wang Xinxuan Duan Kai Sun Yajie Li Lirong Zheng Wenfeng Lin Mingdong Dong Guoxin Zhang Wen Liu Xiaoming Sun | 2020 | Nano-Micro Letters2020，12，9： | 1 |
| 16 | Reconstructing avascular necrotic femoral head through a bioactiveβ-TCP system:From design to application显示文摘A variety of techniques have been used for treating avascular necrosis of the femoral head(ANFH),but have frequently failed.In this study,we proposed aβ-TCP system for the treatment of ANFH by boosting revascularization and bone regeneration.The angio-conductive properties and concurrent osteogenesis of the highly interconnected porousβ-TCP scaffold were revealed and quantified through an in vivo model that simulated the ischemic environment of ANFH.Mechanical test and finite element analysis showed that the mechanical loss caused by tissue necrosis and surgery was immediately partially compensated after implantation,and the strength of the operated femoral head was adaptively increased and eventually returned to normal bone,along with continuous material degradation and bone regeneration.For translational application,we further conducted a multi-center open-label clinical trial to assess the efficacy of theβ-TCP system in treating ANFH.Two hundred fourteen patients with 246 hips were enrolled for evaluation,and 82.1%of the operated hips survived at a 42.79-month median follow-up.The imaging results,hip function,and pain scores were dramatically improved compared to preoperative levels.ARCO stage II disease outperformed stage III in terms of clinical effectiveness.Thus,bio-adaptive reconstruction using theβ-TCP system is a promising hip-preserving strategy for the treatment of ANFH. | Yajie Lu Xiantao Chen Xiao Lu Changning Sun Minghui Li Guojing Chen Zuoyao Long Yuan Gao Haoqiang Zhang Mengquan Huang Chuanlei Ji Hongbin Fan Dong Liu Yuewen Hao Hong Wang Leilei Zhang Hongmei Zhang Jianxi Lu Zhen Wang Jing Li | 2023 | Bioactive Materials2023，，10： | 1 |
| 17 | Molecular cloning, functional analysis and localization of a novel gene encoding polygalacturonase-inhibiting protein in Chorispora bungeana显示文摘 | Cuixia Di Ming Li Feng Long Muqun Bai Yajie liu Xiaolin Zheng Shijian Xu Yun Xiang Zhenglong Sun Lizhe An | 2009 | Planta2009，，1： | 1 |
| 18 | Is the End of the T-Tube Drainage Era in Laparoscopic Choledochotomy for Common Bile Duct Stones Is Coming? A Systematic Review and Meta-Analysis显示文摘 | Zi Yin Kang Xu Jian Sun Jianlong Zhang Zhiyu Xiao Jie Wang Haitao Niu Qiang Zhao Shangxiong Lin Yajie Li | 2013 | Annals of Surgery2013，，1： | 1 |
| 19 | Is the End of the T-Tube Drainage Era in Laparoscopic Choledochotomy for Common Bile Duct Stones Is Coming? A Systematic Review and Meta-Analysis显示文摘 | Zi Yin Kang Xu Jian Sun Jianlong Zhang Zhiyu Xiao Jie Wang Haitao Niu Qiang Zhao Shangxiong Lin Yajie Li | 2013 | Annals of Surgery2013，，1： | 1 |
| 20 | Research on the Signal Reconstruction of the Phased Array Structural Health Monitoring Based Using the Basis Pursuit Algorithm显示文摘The signal processing problem has become increasingly complex and demand high acquisition system,this paper proposes a new method to reconstruct the structure phased array structural health monitoring signal.The method is derived from the compressive sensing theory and the signal is reconstructed by using the basis pursuit algorithm to process the ultrasonic phased array signals.According to the principles of the compressive sensing and signal processing method,non-sparse ultrasonic signals are converted to sparse signals by using sparse transform.The sparse coefficients are obtained by sparse decomposition of the original signal,and then the observation matrix is constructed according to the corresponding sparse coefficients.Finally,the original signal is reconstructed by using basis pursuit algorithm,and error analysis is carried on.Experimental research analysis shows that the signal reconstruction method can reduce the signal complexity and required the space efficiently. | Yajie Sun Yanqing Yuan Qi Wang Lihua Wang Enlu Li Li Qiao | 2019 | Computers, Materials & Continua2019，，2： | 1 |
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