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| 1 | Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy显示文摘An essential concept of cancer immunotherapy is that immunogenic cell death(ICD),characterized by the release of tumor-associated antigens(TAAs)and tumor-specific antigens(TSAs)like neoantigens,danger-associated molecular patterns(DAMPs),and pro-inflammatory cytokines,facilitates the presentation of TAAs and TSAs to adaptive immune cells,eliciting an emerging or reinstating a pre-existing anti-cancer immune response. | Yajie Sun Xiangru Feng Chao Wan Jonathan F.Lovell Honglin Jin Jianxun Ding | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，2： | 5 |
| 2 | Pm67, a new powdery mildew resistance gene transferred from Dasypyrum villosum chromosome 1V to common wheat(Triticum aestivum L.)显示文摘Powdery mildew, caused by the biotrophic fungus Blumeria graminis f. sp. tritici(Bgt), is a global disease that poses a serious threat to wheat production. To explore additional resistance gene, a wheatDasypyrum villosum 1 V#5(1 D) disomic substitution line NAU1813(2 n = 42) with high level of seedling resistance to powdery mildew was used to generate the recombination between chromosomes 1 V#5 and1 D. Four introgression lines, including t1 VS#5 ditelosomic addition line NAU1815, t1 VL#5 ditelosomic addition line NAU1816, homozygous T1 DL·1 VS#5 translocation line NAU1817, and homozygous T1 DS·1 VL#5 translocation line NAU1818 were developed from the selfing progenies of 1 V#5 and 1 D double monosomic line that derived from F1 hybrids of NAU1813/NAU0686. All of them were characterized by fluorescence in situ hybridization, genomic in situ hybridization, 1 V-specific markers analysis, and powdery mildew tests at different developmental stages. A new powdery mildew resistance gene named Pm67 was physically located in the terminal bin(FL 0.70–1.00) of 1 VS#5. Lines with Pm67 exhibited seedling stage immunity and tissue-differentiated reactions at adult plant stage. The sheaths, stems, and spikes of the Pm67 line were still immune, but the leaves showed a low degree of susceptibility.Microscopic observation showed that most penetration attempts were stopped in association with papillae on the sheath, and colonies cannot form conidia on the susceptible leaf of Pm67 line at adult plant stage, suggesting that the defence layers of the Pm67 line is tissue-differentiated. Thus, the T1 DL·1 VS#5 translocation line NAU1817 provides a new germplasm in wheat breeding for improvement of powdery mildew resistance. | Ruiqi Zhang Chuanxi Xiong Huanqing Mu Ruonan Yao Xiangru Meng Lingna Kong Liping Xing Jizhong Wu Yigao Feng Aizhong Cao | 2021 | The Crop Journal2021，9，4： | 3 |
| 3 | Polymer nanoparticles as adjuvants in cancer immunotherapy显示文摘Immunotherapy is a promising strategy to inhibit cancer progression viaactivation of the immune system. In immunotherapy, adjuvants as immunologicstimulants or delivery systems play a critical role in inducing the antitumorimmune response and decreasing the side effects of immune stimulants. Polymernanoparticles have attracted increasing attention as an indispensable componentof immunotherapy, owing to their favorable properties, such as excellentbiocompatibility and biodegradability, flexible size, high activity as immunestimulants, large surface area for binding multivalent immune ligands, and highloading capacity for immune-related components. In cancer immunotherap^polymer nanoparticles can protect cargo from the surrounding milieu, deliverthe antigens and immunostimulatory molecules to antigen-presenting cells,or stimulate robust T cell response. This review summarizes the currentadvancements in polymer nanopartide adjuvants for cancer immunotherapyand predicts their prospects in fundamental and clinical studies. | Shengxian Li Xiangru Feng Jixue Wang Liang He Chunxi Wang Jianxun Ding Xuesi Chen | 2018 | Nano Research2018，11，11： | 3 |
| 4 | Biointerface engineering nanoplatforms for cancer-targeted drug delivery显示文摘Over the past decade,nanoparticle-based therapeutic modalities have become promising strategies in cancer therapy.Selective delivery of anticancer drugs to the lesion sites is critical for elimination of the tumor and an improved prognosis.Innovative design and advanced biointerface engineering have promoted the development of various nanocarriers for optimized drug delivery.Keeping in mind the biological framework of the tumormicroenvironment,biomembrane-camouflaged nanoplatforms have been a research focus,reflecting their superiority in cancer targeting.In this review,we summarize the development of various biomimetic cell membrane-camouflaged nanoplatforms for cancertargeted drug delivery,which are classified according to the membranes fromdifferent cells.The challenges and opportunities of the advanced biointerface engineering drug delivery nanosystems in cancer therapy are discussed. | Huaiyu Zhang Shujun Dong Zhongmin Li Xiangru Feng Weiguo Xu Catrina Mae STulinao Yang Jiang Jianxun Ding | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，4： | 1 |
| 5 | Shading during the grain filling period increases 2-acetyl-1-pyrroline content in fragrant rice显示文摘 | Zhaowen Mo Wu Li Shenggang Pan Timothy L Fitzgerald Feng Xiao Yongjian Tang Yilei Wang Meiyang Duan Hua Tian Xiangru Tang | 2015 | Rice2015，，1： | 1 |
| 6 | Development of Heart Failure and Congenital Septal Defects in Mice Lacking Endothelial Nitric Oxide Synthase显示文摘 | Qingping Feng Wei Song Xiangru Lu Joel A. Hamilton Ming Lei Tianqing Peng Siu-Pok Yee | 2002 | Circulation: Journal of the American Heart Association2002，，7： | 1 |
| 7 | Superiority of poly(L-lactic acid)microspheres as dermal fillers显示文摘The demand for injectable dermal filler has unde rgone significant growth with the rapid development of the beauty industry.Poly(lactic acid)(PLA) as a benefit of excellent biocompatibility and long-term promotion of collagen regeneration has been favored as a commonly used filler.However,the effects of chirality and particle size of PLA on the efficacy of dermal filler have not been studied.In this study,we prepared three kinds of microspheres(MSs) consisting of poly(D-lactic acid)(PDLA MS),poly(L-lactic acid)(PLLA MS),or meso-PLA(PDLLA MS)at 5,10 and 20 μmto reveal the different biological functions as dermal filler.Following intradermal injection into guinea pig,it was found that PLLA MS induced the slightest inflammation,and the level of pro-inflammatory cytokine IL-1β induced by PLLA MS is only 0.3 or 0.7-fold of that induced by PDLA or PDLLA MS,respectively.More importantly,PLLA MS significantly stimulated the regeneration of collagen,which was 1.4 or 1.1 times higher than those stimulated by PDLA MS or PDLLA MS,respectively.The size of PLA MSs did not affect the levels of inflammation and collagen regeneration.The results confirmed the superiority of PLLA as a dermal filler. | Quan Gao Lijie Duan Xiangru Feng Weiguo Xu | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 8 | Endogenous heme oxygenase induction is a critical mechanism attenuating apoptosis and restoring microvascular perfusion following limb ischemia/reperfusion显示文摘 | Sarah D. McCarter Thelma G. Akyea Xiangru Lu Aurelia Bihari Jeffrey R. Scott Amit Badhwar Alison A. Dungey Kenneth A. Harris Qingping Feng Richard F. Potter | 2004 | Surgery2004，，1： | 1 |
| 9 | Cystine proportion regulates fate of polypeptide nanogel as nanocarrier for chemotherapeutics显示文摘The physicochemical characteristics of nanoparticles are closely related to their drug delivery performances in vitro and in vivo.A well-designed nanocarrier can prolong the drug half-life in the blood circulation,upregulate the drug accumulation at the target site,and enhance the treatment efficacy.To elucidate the impact of physicochemical properties on the fate of nanogel as a nanocarrier of chemotherapeutics,three methoxy poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(mPEG-P(LP-coLC))nanogels with different L-cystine proportions were developed,namely mPEG-P(LP10-co-LC5)(NG10-5),mPEG-P(LP10-coLC10)(NG10-10),and mPEG-P(LP10-co-LC15)(NG10-15).The three nanogels shared similar surface charge and reductionresponsive behavior,but they had distinct diameters and different drug release profiles.Among them,NG10-5,which has the smallest diameter,was preferentially internalized by tumor cells in vitro and showed rapid migration to the tumor site in vivo.Using doxorubicin(DOX)as a model chemotherapeutic agent,NG10-5/DOX had the most prolonged blood circulation period and highest tumor accumulation after intravenous administration.NG10-5/DOX also had the most potent antitumor effect of all three drug-loaded nanogels.Accordingly,adjusting physicochemical characteristics by changing the amino acid composition might improve the therapeutic efficacies of nanogels and enhance their potential for clinical application. | Xiangru Feng Weiguo Xu Xiaoru Xu Gao Li Jianxun Ding Xuesi Chen | 2021 | Science China Chemistry2021，64，2： | 1 |
| 10 | Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice显示文摘 | Qingping Feng Xiangru Lu Douglas L | 2001 | Circulation2001，104，： | 1 |
| 11 | Field programmable topological edge array显示文摘Valley Hall topological photonic crystals,inspired by topological insulators in condensed matter physics,have provided a promising solution to control the flow of light.Recently,the dynamic manipulation property of topological photonic crystals has been widely studied.Here,we propose a novel solution for programmable valley photonic crystals,called field programmable topological edge array(FPTEA),based on the field reorientation property of nematic liquid crystals and robust valley-protected edge modes.FPTEA is composed of an array of graphene-like lattices with C_(3)symmetry,in which the birefringence of liquid crystal is larger than 0.5105.Due to the dielectric anisotropy of liquid crystals being sensitive to external fields such as light,heat,electric,and magnetic fields,each lattice is tunable,and the topological propagation routes and even the lattice parameters can be dynamically changed while changing the distribution of external fields.We numerically demonstrate three methods of composing an FPTEA device to design arbitrary passive optical devices by electric driving,thermal inducing,or UV writing.These results show the great application potential of liquid crystals in topological photonic crystals,and enrich the design of programmable integrated topological devices with broad working bandwidth ranging from microwave to visible light. | XIAOXIAN HE XIANGRU WANG YULIN ZHAO RUSHENG ZHUO FENG LIANG | 2023 | Photonics Research2023，11，3： | 0 |
| 12 | Poly(L-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization显示文摘PEGylation has been widely applied to prolong the circulation times of nanomedicines via the steric shielding effect,which consequently improves the intratumoral accumulation.However,cell uptake of PEGylated nanoformulations is always blocked by the steric repulsion of PEG,which limits their therapeutic effect.To this end,we designed and prepared two kinds of poly(L-glutamic acid)-cisplatin(PLG-CDDP)nanoformulations with detachable PEG,which is responsive to specific tumor tissue microenvironments for prolonged circulation time and enhanced cell internalization.The extracellular pH(pHe)-responsive cleavage 2-propionic-3-methylmaleic anhydride(CDM)-derived amide bond and matrix metalloproteinases-2/9(MMP-2/9)-sensitive degradable peptide PLGLAG were utilized to link PLG and PEG,yielding pHe-responsive PEG-pHe-PLG and MMP-sensitive PEG-MMP-PLG.The corresponding smart nanoformulations PEG-pHe-PLG-Pt and PEG-MMP-PLG-Pt were then prepared by the complexation of polypeptides and cisplatin(CDDP).The circulation half-lives of PEG-pHe-PLG-Pt and PEG-MMP-PLG-Pt were about 4.6 and 4.2 times higher than that of the control PLG-Pt,respectively.Upon reaching tumor tissue,PEG on the surface of nanomedicines was detached as triggered by pHe or MMP,which increased intratumoral CDDP retention,enhanced cell uptake,and improved antitumor efficacy toward a fatal high-grade serous ovarian cancer(HGSOC)mouse model,indicating the promising prospects for clinical application of detachable PEGylated nanoformulations. | Zhongyu Jiang Xiangru Feng Haoyang Zou Weiguo Xu Xiuli Zhuang | 2021 | Bioactive Materials2021，6，9： | 0 |
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