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| 1 | Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer显示文摘AIM:To investigate M2 isoform of pyruvate kinase(PKM2) expression in gastric cancers and evaluate its potential as a prognostic biomarker and an anticancer target.METHODS:All tissue samples were derived from gastric cancer patients underwent curative gastrectomy as a primary treatment.Clinical and pathological information were obtained from the medical records.Gene expression microarray data from 60 cancer and 19 noncancer gastric tissues were analyzed to evaluate the expression level of PKM2 mRNA.Tissue microarrays were constructed from 368 gastric cancer patients.Immunohistochemistry was used to measure PKM2 expression and PKM2 positivity of cancer was determined by proportion of PKM2-positive tumor cells and staining intensity.Association between PKM2 expression and the clinicopathological factors was evaluated and the correlation between PKM2 and cancer prognosis was evaluated.RESULTS:PKM2 mRNA levels were increased more than 2-fold in primary gastric cancers compared to adjacent normal tissues from the same patients(log transformed expression level:7.6 ± 0.65 vs 6.3 ± 0.51,P < 0.001).Moreover,differentiated type cancers had significantly higher PKM2 mRNA compared to undifferentiated type cancers(log transformed expression level:7.8 ± 0.70 vs 6.7 ± 0.71,P < 0.001).PKM2 protein was mainly localized in the cytoplasm of primary cancer cells and detected in 144 of 368(39.1%) human gastric cancer cases.PKM2 expression was not related with stage(P = 0.811),but strongly correlated with gastric cancer differentiation(P < 0.001).Differentiated type cancers expressed more PKM2 protein than did the undifferentiated ones.Well differentiated adenocarcinoma showed 63.6% PKM2-positive cells;in contrast,signet-ring cell cancers showed only 17.7% PKM2-positive cells.Importantly,PKM2 expression was correlated with shorter overall survival(P < 0.05) independent of stage only in signet-ring cell cancers.CONCLUSION:PKM2 expression might be an adverse prognostic factor for signet-ring cell carcinomas.Its function and potential as a prognostic marker should be further verified in gastric cancer. | Jae Yun Lim Sun Och Yoon So Young Seol Soon Won Hong Jong Won Kim Seung Ho Choi Jae Yong Cho | 2012 | World Journal of Gastroenterology2012，18，30： | 19 |
| 2 | Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice显示文摘瞄准:增加的证据建议那 probucol,有抗氧化剂活动的一个类脂化合物阴沉的代理人,可能为有经由在胆固醇和 neuroinflammation 的减小的 hyperlipidemia 的 ischemic 击的治疗有用。在这研究,我们检验了 probucol 是否能在正常和 hyperlipidemic mice.Methods 经由 anti-neuroinflammatory 行动免于大脑 ischemic 损害:主要老鼠 microglia 和鼠科的 BV2 microglia 不为 3 h,和版本暴露于 lipopolysaccharide (LPS ) , PGE2, IL-1β并且在 NF-κ 的 IL-6,以及变化; B,表明小径的 MAPK 和 AP-1 被估计。ApoE 击倒老鼠被喂包含 0.004% 的一本高脂肪的食谱, 0.02% , 0.1%(wt/wt ) 为 10 个星期的 probucol 而正常 C57BL/6J 老鼠收到了 probucol (3, 10, 30 mg· kg -1·d-1, po ) 为 4 d。然后,所有老鼠通过中间的服的动脉吸藏(MCAO ) 受到焦点的服的局部缺血。神经病学的赤字被获得在外科以后的 24 h,然后大脑为测量服的梗塞尺寸和支持 inflammatory mediators.Results 的生产被移开:在对待 LPS 的 BV2 房间和主要 microglial 房间,有 probucol 的预告的处理(1, 5, 10 μ mol/L ) dose-dependently 禁止了版本没有, PGE2, IL-1β并且 IL-6,它发生在抄写铺平。而且, probucol 的禁止的行动与 NF-κ 的 downregulation 被联系;表明小径的 B, MAPK 和 AP-1。在有 MCAO 的正常鼠标, probucol 的管理前 dose-dependently 减少了梗塞卷和改进神经病学的功能。这些效果被支持 inflammatory 调停人的减少的生产伴随(iNOS, COX-2, IL-1, IL-6 ) 。在 ApoE 击倒,老鼠喂了一本高脂肪的食谱, 0.1% probucol 的管理前显著地减少了梗塞体积,改进了跟随 MCAO 的神经病学的赤字,并且减少全部胆固醇并且 LDL 胆固醇 levels.Conclusion:Probucol 禁止导致 LPS 的 microglia 激活并且改善在经由它的 anti-neuroinflammatory 行动的正常和 hyperlipidemic 老鼠的服的 ischemic 损害,建议那 probucol 为 ischemic 击和 hyperlipidemia 为病人的治疗有潜力与或在风险。 | Yeon Suk JUNG Jung Hwa PARK Hyunha KIM So Young KIM Ji Young HWANG Ki Whan HONG Sun Sik BAE Byung Tae CHOI Sae-Won LEE Hwa Kyoung SHIN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 16 |
| 3 | Short-term interval combined chemoembolization and radiofrequency ablation for hepatocellular carcinoma显示文摘AIM:To investigate hepatic function after combined transcatheter arterial chemoembolization(TACE) and radiofrequency ablation(RFA) with a short-term interval(0-2 d).METHODS:A total of 115 patients with compensated liver cirrhosis underwent RFA combined with TACE at a time-interval of 0-2 d for the treatment of hepatocellular carcinoma(HCC)<5.0 cm.There were 21 patients who received further hepatic directed treatment altering liver function within 12 mo after the combined therapy for HCC-recurrence,and were excluded.The remaining94 patients who survived without HCC-recurrence were included in this retrospective study.RESULTS:At 1 mo after treatment,Child-Pugh scores(CPs)remained unchanged in 89 of 94 patients(94.7%),and transiently increased by one-point in 5 patients(5.3%).However,the score returned to baseline score at 3 mo and was maintained until 6 mo in all patients.The baseline CPs of 8 or more was identified as a factor for transient rise of CPs after the treatment(CPs 8/9 vs5/6/7;21.4%vs 2.5%;P=0.022).At 12 mo followup,CPs was unchanged in 90 patients(95.7%),and increased by one-point in 4 patients(4.3%).The rise of CPs at 12 mo was not statistically associated with the initial transient rise of CPs.There were procedure-related complications in 3 patients(3.2%),but the complications were resolved by medical and interventional treatments without hepatic functional sequelae.CONCLUSION:The combined TACE and RFA with an interval of 0-2 d are safe for the management of HCC<5 cm in cirrhotic patients. | Won Hyeok Choe Young Jun Kim Hee Sun Park Sang Woo Park Jeong Han Kim So Young Kwon | 2014 | World Journal of Gastroenterology2014，20，35： | 13 |
| 4 | Assessing significant fibrosis using imaging-based elastography in chronic hepatitis B patients: Pilot study显示文摘BACKGROUND Accurate detection of significant fibrosis(fibrosis stage 2 or higher on the METAVIR scale)is important especially for chronic hepatitis B(CHB)patients with high viral loads but with normal or mildly elevated alanine aminotransferase(ALT)levels because the presence of significant fibrosis is accepted as the indication for antiviral treatment.Liver biopsy is the reference standard for diagnosing significant fibrosis,but it is an invasive procedure.Consequently,noninvasive imaging-based measurements,such as magnetic resonance elastography(MRE)or two-dimensional shear-wave elastography(2DSWE),have been proposed for the quantitative assessment of liver fibrosis.AIM To explore MRE and 2D-SWE to identify fibrosis stage,and to compare their performance with that of serum-based indices.METHODS The study enrolled 63 treatment-na?ve CHB patients with high viral loads but with normal or mildly elevated ALT levels who underwent liver biopsy before a decision was made to initiate antiviral therapy.MRE and 2D-SWE were performed,and serum-based indices,such as FIB-4 and aspartate transaminase to platelet ratio index(APRI),were calculated.The diagnostic performances of MRE,2D-SWE,FIB-4,and APRI for assessing significant fibrosis(≥F2)and cirrhosis(F4)were evaluated with liver histology as the reference standard,using receiver operating characteristic analyses.RESULTS The liver fibrosis stage was F0/F1 in 19,F2 in 14,F3 in 14,and F4 in 16 patients,respectively.MRE significantly discriminated F2 from F0/1(P=0.022),whereas 2D-SWE showed a broad overlap in distinguishing those stages.MRE showed a higher correlation coefficient value with fibrosis stage than 2D-SWE with fibrosis stage(0.869 vs 0.649,Spearman test;P<0.001).Multivariate linear regression analyses showed that fibrosis stage was the only factor affecting the values of MRE(P<0.001),whereas body mass index(P=0.042)and fibrosis stage(P<0.001)were independent factors affecting 2D-SWE values.MRE performance for diagnosing significant fibrosis was better[area under the curve(AUC)=0.906,positive predictive value(PPV)97.3%,negative predictive value(NPV)69.2%]than that of FIB-4(AUC=0.697,P=0.002)and APRI(AUC=0.717,P=0.010),whereas the performance of 2D-SWE(AUC=0.843,PPV 86%,NPV 65%)was not significantly different from that of FIB-4 or APRI.CONCLUSION Compared to SWE,MRE might be more precise non-invasive assessment for depicting significant fibrosis and for making-decision to initiate antiviral-therapy in treatment-na?ve CHB patients with normal or mildly-elevated ALT levels. | Hee Sun Park Won Hyeok Choe Hye Seung Han Mi Hye Yu Young Jun Kim Sung Il Jung Jeong Han Kim So Young Kwon | 2019 | World Journal of Gastroenterology2019，25，25： | 7 |
| 5 | Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells显示文摘Lycium barbarum(LB)is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biological functions,such as antioxidation,neuroprotection,and immune modulation.One of the main mechanisms of Alzheimer’s disease is that microglia activated by amyloid beta(Aβ)transform from the resting state to an M1 state and release pro-inflammatory cytokines to the surrounding environment.In the present study,immortalized microglial cells were pretreated with L.barbarum extract for 1 hour and then treated with oligomeric Aβfor 23 hours.The results showed that LB extract significantly increased the survival of oligomeric Aβ-induced microglial cells,downregulated the expression of M1 pro-inflammatory markers(inducible nitric oxide synthase,tumor necrosis factorα,interleukin-6,and interleukin-1β),and upregulated the expression of M2 anti-inflammatory markers(arginase-1,chitinase-like protein 3,and interleukin-4).LB extract also inhibited the oligomeric Aβ-induced secretion of tumor necrosis factorα,interleukin-6,and interleukin-1βin microglial cells.The results of in vitro cytological experiments suggest that,in microglial cells,LB extract can inhibit oligomeric Aβ-induced M1 polarization and concomitant inflammatory reactions,and promote M2 polarization. | Zhong-Qing Sun Jin-Feng Liu Wei Luo Ching-Hin Wong Kwok-Fai So Yong Hu Kin Chiu | 2022 | Neural Regeneration Research2022，17，1： | 4 |
| 6 | Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time显示文摘 | Keun Ho Ryu Hye Young Han So Young Lee Sun Duck Jeon Guang-Jin Im Bong Yong Lee Keunyoung Kim Kyung-Min Lim Jin-Ho Chung | 2009 | Thrombosis Research2009，，3： | 2 |
| 7 | Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial显示文摘BACKGROUND Increasing levels of antibiotic resistance have reduced the Helicobacter pylori(H.pylori)eradication rates afforded by the standard triple therapy.Thus,2-wk firstline four-drug regimens must be considered.AIM To analyze the eradication rates of modified bismuth-containing quadruple therapy(mBCQT)and concomitant therapy(CT),the associated adverse events,and compliance.METHODS Patients infected with H.pylori were prospectively randomized to receive mBCQT or CT for 2 wk.mBCQT featured a proton pump inhibitor(PPI),bismuth,metronidazole,and tetracycline,taken twice daily.CT included a PPI,clarithromycin,metronidazole,and amoxicillin,taken twice daily.The 13C-urea breath test was performed no earlier than 4 wk after therapy concluded to confirm eradication.If either the histological or rapid urease test was positive,H.pylori infection was diagnosed.RESULTS The demographic characteristics of 68 patients who received mBCQT and 68 who received CT did not differ significantly.On intention-to-treat analysis,the eradication rate was 88.2%(60/68)in the mBCQT group and 79.4%(54/68)in the CT group(P=0.162).By per-protocol analysis,the respective eradication rates were 98.4%(60/61)and 93.1%(54/58)(P=0.199).More CT than mBCQT patients experienced adverse events[33.8%(23/68)mBCQT vs 51.5%(35/58)CT patients,respectively,P=0.037].All patients showed good compliance[85.3%(58/68)mBCQT vs 82.4%(56/68)CT patients,P=0.641].CONCLUSION The H.pylori eradication rates of the 2-wk mBCQT and CT regimens are high.Most patients show good compliance,and more CT than mBCQT patients experience adverse events. | So Jeong Kim Jun-Won Chung Hyun Sun Woo Su Young Kim Jung Ho Kim Yoon Jae Kim Kyoung Oh Kim Kwang An Kwon Dong Kyun Park | 2019 | World Journal of Gastroenterology2019，25，46： | 2 |
| 8 | Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis显示文摘 | Hyoung‐Mo Yang Seung‐Jea Tahk Hong‐Seok Lim Myeong‐Ho Yoon So‐Yeon Choi Byoung‐Joo Choi Xiong Jie Jin Gyo‐Seung Hwang Jin‐Sun Park Joon‐Han Shin | 2014 | Intervent2014，，3： | 1 |
| 9 | Screening test data analysis for liver disease prediction model using growth curve显示文摘 | Young Sun Kim So Young Sohn Chang No Yoon | 2003 | Biomedecine&Pharmacotherapy2003，57，10： | 1 |
| 10 | Role for p27(Kip1)in Vascular Smooth Muscle Cell Migration显示文摘 | SUN J MARX SO CHEN HJ | 2001 | Circulation2001，103，24： | 1 |
| 11 | Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF-κB显示文摘 | ]Sun Mi Kim So Yong Lee Jin Suk Cho | 2010 | Molecular and Cellular Pharmacology2010，10，： | 1 |
| 12 | Comparison of embryo toxicity of ESBO and phthalate esters using an invitro battery system显示文摘 | Gyu Seek Rhee So Hee Kim Soon Sun Kim | 2002 | Toxicolvitro2002，16，： | 1 |
| 13 | CD11b+ Gr1+ bone marrow cells ameliorate liver fibrosis by producing interleukin‐10 in mice显示文摘 | Yang‐Gun Suh Ja Kyung Kim Jin‐Seok Byun Hyon‐Seung Yi Young‐Sun Lee Hyuk Soo Eun So Yeon Kim Kwang‐Hyub Han Kwan Sik Lee Gregg Duester Scott L. Friedman Won‐Il Jeong | 2012 | Hepatology2012，，5： | 1 |
| 14 | Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia显示文摘 | Yu Sun Chung Do-Hyung Kang Na Young Shin So Young Yoo Jun Soo Kwon | 2007 | Schizophrenia Research2007，，： | 1 |
| 15 | Comparison of embryo toxicity of ESBO and pbthalate esters using an invitro battery system显示文摘 | Gyu Seek Rhee So Hee Kim Soon Sun Kim | 2002 | Toxicolvitro2002，16，： | 1 |
| 16 | Overexpression of 14-3-3 protein protects pheochromocytoma cells against 1-methyl-4-phenylpyridinium toxicity 显示文摘 | Chen XW Sun SO Cheng DB | 2006 | Neurosci Bull2006，22，5： | 1 |
| 17 | Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF-κB显示文摘 | Sun Mi Kim So Yong Lee Jin Suk Cho Seung Mo Son Sang Sook Choi Yeo Pyo Yun Hwan Soo Yoo Do Young Yoon Ki-Wan Oh Sang Bae Han Jin Tae Hong | 2009 | European Journal of Pharmacology2009，，1： | 1 |
| 18 | Factors affecting quality of life in Korean patients with chronic heart failure显示文摘 | Sang Hui CHU Won Hee LEE Ji Soo YOO So Sun KIM Il Sun KO Eui Geum OH JuHee LEE Mona CHOI Joo Young CHEON Chi Young SHIM Seok‐Min KANG | 2014 | Japan Journal of Nursing Science2014，，1： | 1 |
| 19 | Column-switchinghigh-performance liquid chromatographic method for the determi-nation of zaltoprofen in rat plasma显示文摘 | Sun Ok Choi So Young Uma Sung Hee Jung | 2006 | Journal of ChromatographyB2006，830，： | 1 |
| 20 | Preparation of (1→4)-β-D-Xylooligosaccharides from An Acid Hydrolysate of Cotton-seed Xylan:Suitability of Cotton-seed Xylan as a Starting Material for the Preparation of (1→4)-β-D-Xylooligosaccharides显示文摘 | Shigeki Yashida and so on | 2002 | Carbohydrate Research2002，，331： | 1 |
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