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| 1 | Risk of lymph node metastasis in mixed-type early gastric cancer determined by the extent of the poorly differentiated component显示文摘AIM: To predict the rate of lymph node(LN) metastasis in diffuse- and mixed-type early gastric cancers(EGC) for guidelines of the treatment.METHODS: We reviewed 550 cases of EGC withdiffuse- and mixed-type histology. We investigated the clinicopathological factors and histopathological components that influence the probability of LN metastasis, including sex, age, site, gross type, presence of ulceration, tumour size, depth of invasion, perineural invasion, lymphovascular invasion, and LN metastasis status. We reviewed all slides and estimated the proportions of each tumour component; pure diffuse type, mixed-predominantly diffuse type(diffuse > intestinal type), mixed-predominantly intestinal type(intestinal > diffuse type), and mixed diffuse = intestinal type. We calculated the extents of the respective components.RESULTS: LN metastasis was observed in 12.9%(71/550) of early gastric cancers cases [15/288 mucosal EGCs(5.2%) and 56/262 submucosal EGCs(21.4%)]. Of 550 cases, 302 were diffuse-type and 248 were mixed-type EGCs. Of 248 mixed-type EGCs, 163 were mixed-predominantly diffuse type, 82 were mixed-predominantly intestinal type, and 3 were mixed diffuse = intestinal type. Mixed-type cases with predominantly diffuse type histology showed a higher frequency of LN metastasis(20.2%) than cases of pure diffuse type(9.3%) and predominantly intestinal type(12.2%) histology. We measured the dimensions of each component(intestinal and diffuse type) to determine the association of the extent of each component with LN metastasis in mixed-type gastric carcinoma. The total tumour size and the extent of poorly differentiated components was associated with LN metastasis, while that of signet ring cell components was not.CONCLUSION: We recommend careful identification and quantitative evaluation of mixed-type early gastric cancer components after endoscopic resection to determine the intensity of the treatment. | Chung-Su Hwang Sangjeong Ahn Bong-Eun Lee So-Jeong Lee Ahrong Kim Chang In Choi Dae Hwan Kim Tae-Yong Jeon Gwang Ha Kim Geum Am Song Do Youn Park | 2016 | World Journal of Gastroenterology2016，22，15： | 8 |
| 2 | The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Hee Chul Park Jeong Il Yu Won Sohn Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Liver Int2014，，5： | 5 |
| 3 | Frequency and risk factors of renal impairment during long‐term adefovir dipivoxil treatment in chronic hepatitis B patients显示文摘 | Yu JinKim Hyun ChinCho Dong HyunSinn Geum‐YounGwak Moon SeokChoi Kwang CheolKoh Seung WoonPaik Byung ChulYoo Joon HyeokLee | 2012 | Journal of Gastroenterology and Hepatology2012，，2： | 2 |
| 4 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 5 | Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance显示文摘 | Kim Dae Hwan Shin Nari Kim Gwang Ha Song Geum Am Jeon Tae-Yong Kim Dong-Heon Lauwers Gregory Y Park Do Youn | 2013 | Archives of Pathology & Laboratory Medicine2013，，8： | 2 |
| 6 | Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition显示文摘 | Johannes Kluwe Jean–Philippe Pradere Geum–Youn Gwak Ali Mencin Samuele De Minicis Christoph H. ?sterreicher Jordi Colmenero Ramon Bataller Robert F. Schwabe | 2010 | Gastroenterology2010，，1： | 2 |
| 7 | Effect of diabetes mellitus on outcomes of colorectal cancer显示文摘 | Geum Youb Noh Dae-Yong Hwang Yoon Hee Choi | 2010 | J Korean Soc of Coloproctol2010，26，6： | 1 |
| 8 | Discharge and ozone generation characteristics of a ferroelectric-ball/mica-sheet barrier显示文摘 | Jae-Duk Moon Sang-Taek Geum | 1998 | IEEE Trans on industry applications1998，34，6： | 1 |
| 9 | Energy transfer in Li(3P)- H2 collisions显示文摘 | Bililign S Hattablay B C Geum N | 2000 | J Phys Chem A2000，104，： | 1 |
| 10 | Designing the sustainable product-service integration : a product-service blueprint approach 显示文摘 | Geum Y Park Y | 2011 | Jour- nal of Cleaner Production2011，19，14： | 1 |
| 11 | Clinical parameters predictive of outcomes in sorafenib‐treated patients with advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Ho Yeong Lim Young Gon Kim Hyo Keun Lim Yang Won Min Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2013 | Liver Int2013，，6： | 1 |
| 12 | Factors affecting quality of life in Korean patients with chronic heart failure显示文摘 | Sang Hui CHU Won Hee LEE Ji Soo YOO So Sun KIM Il Sun KO Eui Geum OH JuHee LEE Mona CHOI Joo Young CHEON Chi Young SHIM Seok‐Min KANG | 2014 | Japan Journal of Nursing Science2014，，1： | 1 |
| 13 | Technological convergence of IT and BT: Evidence from patent analysis 显示文摘 | GEUM Y KIM C LEE S | 2012 | Etri Journal2012，34，3： | 1 |
| 14 | Circadian rhythm hypotheses of mixed features, antidepressant treatment resistance, and manic switching in bipolar disorder 显示文摘 | LEE H J SON G H GEUM D | 2013 | Psychiatry Investig2013，10，3： | 1 |
| 15 | Technological Convergence of IT and BT: Evidence From Patent Analysis显示文摘 | Geum Y Kim C Lee S | 2012 | Etri Journal2012，34，3： | 1 |
| 16 | Symptom experience, psychological distress, and quality of life in Korean patients with liver cirrhosis: A cross-sectional survey显示文摘 | Soo Hyun Kim Eui Geum Oh Won Hee Lee | 2005 | International Journal of Nursing Studies2005，，8： | 1 |
| 17 | Glucocorticoid inhibits growth factor-induced differentiation of hippocampal progenitor HiB5 显示文摘 | Son GH Geum D Jung H | 2001 | J Neurochem2001，79，： | 1 |
| 18 | A systematic approach for di- agnosing service failure: service-specific FMEA and grey rela- tional analysis approach 显示文摘 | GEUM Y J CHO Y PARK Y | 2011 | Mathematical and Computer Modeling2011，54，1112： | 1 |
| 19 | Technological convergence of IT and BT: Evidence from patent analysis 显示文摘 | Geum Y Kim C Lee S | 2012 | Etri Journal2012，34，3： | 1 |
| 20 | Effective Corona Discharge and Ozone Generation from a Wire-plate Discharge System with a Slit Dielectric Barrier显示文摘 | MOON J D GEUM S T | 2007 | Journal of Electrostatics2007，65，10： | 1 |
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