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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems显示文摘 | Jiantao Feng Fang Wang Xinxiao Han Zhuo Ao Quanmei Sun Wenda Hua Peipei Chen Tianwei Jing Hongyi Li Dong Han | 2014 | Nano Research2014，7，3： | 18 |
| 3 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 4 | “All‐In‐One” integrated ultrathin SnS2@3D multichannel carbon matrix power high‐areal–capacity lithium battery anode显示文摘Construction of a thickness‐independent electrode with high active material mass loading is crucial for the development of high energy rechargeable lithium battery.Herein,we fabricate an all‐in‐one integrated SnS2@3D multichannel carbon matrix(SnS2@3DMCM)electrode with in‐situ growth of ultrathin SnS2 nanosheets inside the inner walls of three dimensional(3D)multichannels.The interconnected conductive carbon matrix derived from natural wood acts as an integrated porous current collector to avail the electrons transport and accommodate massive SnS2 nanosheets,while plenty of 3D aligned multichannels facilitate fast ions transport with electrode thickness‐independent even under high mass loading.As expected,the integrated SnS2@3DMCM electrode exhibits remarkable electrochemical lithium storage performance,such as exceptional high‐areal‐capacity of 6.4 mAh cm−2,high rate capability of 3 mAh cm−2 under current of 6.8 mAcm−2(10 C),and stable cycling performance of 6.8 mAcm−2 with a high mass loading of 7mg cm−2.The 3D integrated porous electrode constructing conveniently with the natural source paves new avenues towards future high‐performance lithium batteries. | Hongyi Xu Chengxin Peng Yuhua Yan Fei Dong Hao Sun Junhe Yang Shiyou Zheng | 2019 | Carbon Energy2019，1，2： | 4 |
| 5 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 6 | Controlled synthesis of Zeolite adsorbent from lowgrade diatomite:A case study of self-assembled sodalite microspheres显示文摘Highly efficient and sustainable conversion technologies to generate uniform sodalite(Na8(AlSiO4)6(OH)2)zeolite micro spheres with low-grade waste natural diatomite as raw materials via a solution-mediated crystallization route were developed in the present study.The synthesis process can be considered as an in-situ zeolitization of diatomite precursor without involving any me so scale template and any post-synthetic modification.The mass ratios of diatomite and AlCl3·6 H2 O have remarkable effect on the morphology,crystal structure and porosity of sodalite zeolite product.The preferred sodalite microspheres with uniform mesoporous of size 3.5-5.5 nm and large surface area of 162.5 m2/g exhibit well removal performance for heavy metal ions(Pb(II),Cd(II),Zn(II),and Cu(II)),with the highest adsorption abilities for Pb(II)ions of 365 mg/g.In addition,the effect of contact time,initial ion concentration,competitive adsorption and solution pH were evaluated.The removal performance results from synergistic effects of dominating cation-exchange and additional surface chemisorption.The study may broadly help unveil chemical control reactions of the zeolitization processes of diatomite,and thus facilitates the development of promising zeolite materials for the use in natural and engineered aquatic environments by recvcling waste diatomite resources. | Lingmin Sun Junshu Wu Jinshu Wang Gong Yu Jingchao Liu Yucheng Du Yongli Li Hongyi Li | 2020 | Journal of Environmental Sciences2020，32，5： | 3 |
| 7 | Application on the'Shear-Extrusion'Process to Form Large-size High-pressure Valve Bodies显示文摘This paper describes a new metal plastic forming process named 'shear-extrusion'. The new process is studied by using numerical analysis and experiment methods, and applied to form large-size high pressure valve bodies used by power plant boiler. Finally, the valve bodies have been successfully formed on the 10000 kN screw press. | Hongyi SUN Yu CHEN Dachang KANG | 2001 | Journal of Materials Science & Technology2001，17，1： | 3 |
| 8 | Porous graphene paper for supercapacitor applications显示文摘Graphene paper shows a great promise for the electrical energy storage. However, the high stability, purity and specific surface area have become stringent requirements for supercapacitor applications. Finding methods to tackle these problems is rather challenging. Here, we develop a facile method to prepare porous graphene papers with a thickness 0.5 mm by a thermal shock to the layer-structure graphene paper self-assembled on Cu foil under nitrogen flowing. The as-prepared porous graphene paper exhibits a large specific capacitance of 100 F g^(-1)at the scan rate of 100 m V s^(-1)with high stability and purity without any residual chemical reagents, showing a promising potential for supercapacitor applications. The high electrochemical properties are mainly attributed to the high-specific area and the improved conductivity of the porous graphene paper performed by the multieffect of reducing, cleaving and expanding to the layer-structure graphene paper by high-energy thermal heating during the thermal shock process. This work paves a pathway to the facile preparation of porous graphene paper for supercapacitor applications. | Qi Li Xinli Guo Yao Zhang Weijie Zhang Chuang Ge Li Zhao Xiaojuan Wang Hongyi Zhang Jian Chen Zengmei Wang Litao Sun | 2017 | Journal of Materials Science & Technology2017，33，8： | 2 |
| 9 | Radial Anisotropy in the Crust beneath the Northeastern Tibetan Plateau from Ambient Noise Tomography显示文摘Through analysis of Rayleigh wave and Love wave Green's functions estimated from ambient noise tomography, we obtain radial anisotropy and shear wave velocity structure beneath the northeastern Tibetan Plateau. With two hundred and twenty three broadband seismic stations deployed by China Earthquake Administration, a collaborative seismic experiment of northern Tibet(ACSENT) experiment and northeastern Tibet seismic(NETS) experiment provide the unprecedented opportunity to resolve the spatial distribution of the radial anisotropy within the crust of the northeastern Tibetan Plateau. Discrepancies between Love(sh) and Rayleigh(sv) wave velocities show complex anisotropic patterns associated with the dynamic processes of the collision between the Indian and Eurasian plates:(1) In the upper crust, V_(sv)>V_(sh) anisotropy is dominant throughout the study area which probably reflects fossil microcracks induced by the uplift, folding and erosion geodynamic processes;(2) in the middle crust, V_(sh)>V_(sv) observed beneath the Songpan-Ganzi terrane and the northwestern Qilian orogen correlates well with a mid-crustal low velocity zone(LVZ);(3) at depths deeper than 40 km, V_(sh)>V_(sv) is still found in the Songpan-Ganzi terrane. This anisotropy could be caused by the sub-horizontal alignment of anisotropic minerals that has followed the collision between India and Eurasia. However, the northwestern Qilian orogen is associated with V_(sv)>V_(sh) anisotropy which may be related to the vertically aligned seismic anisotropic minerals caused by the crustal thickening. | Jing Tan Hongyi Li Xinfu Li Ming Zhou Longbin Ouyang Sanjian Sun Dan Zheng | 2015 | Journal of Earth Science2015，26，6： | 2 |
| 10 | Au nanoparticles decorated graphene/nickel foam nanocomposite for sensitive detection of hydrogen peroxide显示文摘The Au nanoparticles decorated graphene(AuNPs@Gr)/nickel foam(Gr/NiF) nanocomposite(AuNPs@Gr/NiF) was prepared by chemical vapor deposition followed by electrophoretic deposition of AuNPs on Gr/NiF. The morphology, microstructure and sensing performance of the as-prepared AuNPs@Gr/NiF nanocomposite were characterized and measured, respectively by scanning electron microscope, transmission electron microscope, ultraviolet visible spectroscopy and chemical workstation. The asprepared AuNPs@Gr/NiF nanocomposite was used as the electrode to construct a chemical sensor for the detection of hydrogen peroxide(H_2O_2). The results showed that the AuNPs distributed homogenously and stably on the surface of Gr/NiF. The chemical sensor exhibits a sensitive and selective performance to the detection of H_2O_2. | Xiaojuan Wang Xinli Guo Jian Chen Chuang Ge Hongyi Zhang Yuanyuan Liu Li Zhao Yao Zhang Zengmei Wang Litao Sun | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 11 | Waveguide design and application with transformation optics显示文摘Waveguide design becomes more and more important with the increasing demand of efcient routing and interconnection of electromagnetic signals for advanced information technologies.Here we review the basic theory,special techniques,and potential applications of transformation optics in waveguide design.Three major design strategies of transformation optics and their limitations in waveguide applications are discussed.The recent new trends of transformation techniques by imposing specifc restrictions from materials are emphasized for practical implementation.Plasmonic waveguide is used as an example to compare these transformation strategies.Applications beyond waveguides but with great practical value such as super-resolution hyperlens design are also discussed in the context of waveguiding phenomena from the perspective of transformation optics. | XU HongYi SUN HanDong ZHANG BaiLe | 2013 | Science China(Information Sciences)2013，56，12： | 2 |
| 12 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 13 | Current and future patterns of using advanced manufacturing technologies 显示文摘 | Sun Hongyi | 2000 | Technovation Volume 20 Issue 11 November2000，，： | 1 |
| 14 | Effect of the OH ions on SiO2/ SPG/SiO2/InSb device stability 显示文摘 | Hongyi Su Weiguo Sun | 1994 | SPIE Proceedings1994，2274，： | 1 |
| 15 | Buffer Bank storage:an economic, scalable and universally usable in-network storage model for streaming data applications显示文摘Large-scale streaming media distribution services impart unprecedented pressures and challenges to existing Internet architecture. Researchers have proposed CDN, P2 P Cache, ICN and other solutions to alleviate the pressure of the core network, as well as improve the user experience(Qo E). All these solutions achieve their goals by deploying storage resources close to the end users to cache the hot data. Based on the advantages of P2 P service, which takes into account end-users resources, we proposed the Buffer Bank Storage(BBS). It is a new streaming media distribution-oriented storage model by aggregating end-users resources. This provides a novel approach for implementation of economic, scalable, dynamically deploy streaming media distribution applications. However, the dynamic character of the end-user behavior brings challenges to BBS designation. In our previous work, we have analyzed the basic principle of BBS and its feasibility. There is lack of substantial research on resources management and reliability assessment, which are the core issue of BBS implementation.After carefully analyzing the reliability and security issue in BBS deployment, this paper has proposed the implementation model of BBS and studied the performance of different buffer allocation mechanism through simulation. Our work mainly provides a new way of thinking for the dynamic, universal scalable storage system in the Internet, that suffers 'weak reliability'. | Hongyi CHEN Zhigang SUN Fei YI Jinshu SU | 2016 | Science China(Information Sciences)2016，59，1： | 1 |
| 16 | Research on the 'shear-extrusion' process to form large-scale cut-off valve bodies显示文摘 | Kang Dachang Sun HongYi Chen Yu Yang Hongliang | 2001 | Journal of Materials processing Technology2001，117，： | 1 |
| 17 | The simu-ltaneous impect of spplier and customer invol-vement on new product performance显示文摘 | Sun Hongyi Yau H K Suen Eric | | 0，，04： | 1 |
| 18 | Variation in winter daily range area of red deer(Cervus elaphus xanthopygus) based on DNA extracted from fecal samples显示文摘With environmental change and increased human activity,wild red deer(Cervus elaphus xanthopygus)populations and habitat area continue to decrease.Red deer is a main prey species of Amur tiger(Panthera tigris altaica).Factors affecting red deer winter home range in the Wanda montains of northeast China are not well understood.In this study,we aimed to better document red deer daily ranges to support conservation of red deer.A second objective was to develop a practical research method combining macro-and micro-technology for home range research on a variety of rare or endangered wild species.We collected 105 fresh fecal samples of red deer in three different periods during winter from December 2012 to March 2013 in the Wandashan region,Heilongjiang Province,China.Individual and sex identities were analyzed based on fecal DNA using microsatellite DNA.We used samples from deer farms for correction and validation of our identifications from field samples.We used a combination of molecular scatology,3S techniques(GPS),and direct observation to estimate winter daily range areas.Based on eleven microsatellite loci,we identified 18 individuals,10 females and 8 males,with a correction factor of 1.00 and sex ratio of 1:0.8.The mean(±SE)number of alleles was 5.1±0.41,and mean polymorphism information content was 0.63±0.03.Expected heterozygosity ranged from 0.46 to 0.81,with a mean of 0.69±0.03,and mean observed heterozygosity was 0.73±0.07.Sizes of mean daily ranges were 26.1±1.1 ha in December,89.3±1.6 ha in January,and 67.5±1.9 ha in March,indicating the following trend for daily range area:middle winter>late winter>early winter.Mean daily range area was insignificantly larger for males than for females.Estimated winter daily ranges were similar to those reported for Europe.Our combination of macro-and micro-technology proved useful for estimating winter home range areas of red deer. | Miao Yang Yue Sun Wei Qi Zhang Hongyi Yuan Minghai Zhang | 2019 | Journal of Forestry Research2019，30，5： | 1 |
| 19 | Annual Operation Status of SECRAL in 2009显示文摘 | Lu Wang Sun Liangting Feng Yucheng Guo Xiaohong Zhang Xuezheng Li Jingyu Cao Yun Wang Hui Ma Baohua Shang Yong Sha Shan Ma Hongyi Li Xixia Lin Shuhao Zhang Wenhui Jin Tao Zhao Huanyu Zhao Hongwei | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 20 | Operation of LECR3显示文摘 | Feng Yueheng Ma Baohua Wang Hui Li Jinyu Cao Yun Shang Yong Lu Wang Sha Shan Ma Hongyi Zhang Wenhui Lin Shuhao Li Xixia Zhao Huanyu Miao Tingting Guo Xiaohong Zhang Xuezhen Sun Liangting | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
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