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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Computational Cavitation Flows at Inception and Light Stages on an Axial-Flow Pump Blade and in a Cage-Guided Control Valve显示文摘在轴流动的泵片附近并且在一个高压力笼子类型阀门内导致的成穴流动被二维的不稳定的海军司烧分析与水泡动力学的最简单的处理模仿。液体作为水和蒸汽原子核的同类的驱散的混合的连续统被假定。分析被瞄准特别在成穴开始的舞台在水泡的出生和倒塌期间与高振幅压力变化捕获短暂舞台。由泵片分析,地压力在是中等的,开始的成穴数字和发达成穴的地点被发现在在高发生和否定发生之间的一个宽流动范围同意试验性的结果。在阀门流动分析, 5MPa 的水压力在被归结为 2MPa,压力变化对在蒸汽压力之间的水泡倒塌作出回应比 1 KPa 和极端压力降低高,比 104, KPa 通过稳定的计算被捕获。到阀门塞子的开始水泡和压力力量的地点被发现与各自的试验性的特征同意很好。 | Sumio SAITO MasahiroSHIBATA HideoFUKAE Eisuke OUTA | 2007 | Journal of Thermal Science2007，16，4： | 12 |
| 3 | MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors显示文摘AIM:To clarify differences in mucin phenotype, prolif-erative activity and oncogenetic alteration among subtypes of colorectal laterally spreading tumor (LST). METHODS:LSTs, defined as superficial elevated lesions greater than 10 mm in diameter with a low vertical axis, were macroscopically classified into two subtypes:(1) a granular type (Gr-LST) composed of superficially spreading aggregates of nodules forming a flat-based lesion with a granulonodular and uneven surface; and (2) a non-granular type (NGr-LST) with a flat smooth surface and an absence of granulonodular formation. A total of 69 LSTs, comprising 36 Gr-LSTs and 33 NGr-LSTs, were immunohistochemically stained with MUC2, MUC5AC,MUC6, CD10 (markers of gastrointestinal cell lineage), p53, β-catenin and Ki-67 antibodies, and examined for alteration in exon 1 of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and exon 15 of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) by poly-merase chain reaction followed by direct sequencing. RESULTS:Histologically, 15 Gr-LST samples were adenomas with low-grade dysplasia (LGD), 12 were high-grade dysplasia (HGD) and 9 were adenocarcinomas invading the submucosa (INV), while 12 NGr-LSTs demonstrated LGD, 14 HGD and 7 INV. In the proximal colon, MUC5AC expression was significantly higher in the Gr-type than the NGr-type. MUC6 was expressed only in NGr-LST. MUC2 or CD10 did not differ. P53 expression demonstrated a significant stepwise increment in progression through LGD-HGD-INV with both types of LST. Nuclear β-catenin expression was significantly higher in the NGr-type. Ki-67 expression was signifi-cantly higher in the Gr-type in the lower one third zone of the tumor. In proximal, but not distal colon tumors, the incidence of KRAS provided mutation was signifi-cantly higher in the Gr-type harboring a specific mutational pattern (G12V). BRAF mutations (V600E) were detected only in two Gr-LSTs. CONCLUSION:The two subtypes of LST, especially in the proximal colon, have differing phenotypes of gastrointestinal cell lineage, proliferation and activation of Wnt/β-catenin or RAS/RAF/extracellular signal-regulated kinase signaling. | Kosaburo Nakae Hiroyuki Mitomi Tsuyoshi Saito Michiko Takahashi Takashi Morimoto Yasuhiro Hidaka Naoto Sakamoto Takashi Yao Sumio Watanabe | 2012 | World Journal of Gastroenterology2012，18，39： | 8 |
| 4 | Seasonal variations in the onset of ulcerative colitis in Japan显示文摘AIM:To investigate seasonal variations in the onset and relapse of ulcerative colitis(UC)in Japanese patients.METHODS:Between 1994 and 2006,198 Japanese patients diagnosed with UC according to conventional criteria in an academic hospital were enrolled for onset evaluation.Among 265 Japanese patients with UC who were observed for more than 12 mo,165 patients relapsed(239 times)and were enrolled for relapse evaluation.The patients’symptoms were recorded each month for 12 consecutive years.RESULTS:There was monthly seasonality in symptom onset during October and March for UC.The onset of symptoms in UC patients frequently occurred during the winter.Variation in UC onset was observed according to both month(P=0.015)and season(P=0.048).Relapse commonly occurred in October,and variations in relapse were not significant either in month(P=0.52)or season(P=0.12).Upper respiratory inflammation was the main factor responsible for relapse.CONCLUSION:Our results suggest that environmental factors associated with winter and spring seasonality may be responsible for triggering the clinical onset of UC in Japan. | Shigeo Koido Toshifumi Ohkusa Hiroaki Saito Tetsuji Yokoyama Tomoyoshi Shibuya Naoto Sakamoto Kan Uchiyama Hiroshi Arakawa Taro Osada Akihito Nagahara Sumio Watanabe Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，47： | 3 |
| 5 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 6 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 7 | Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver显示文摘 | Kazuo Okumoto Takafumi Saito Hiroaki Haga Etsuko Hattori Rika Ishii Tetsuru Karasawa Akihiko Suzuki Keiko Misawa Mai Sanjo Jun-itsu Ito Kazuhiko Sugahara Koji Saito Hitoshi Togashi Sumio Kawata | 2006 | Journal of Gastroenterology2006，，1： | 1 |
| 8 | Adjuvant effects of fluoride on oral immunization of chickens显示文摘 | Sumio Hoshi Nobuko Saito Ko-ichi Kusanagi | 1998 | Veterinary Immunology and Immunopathology1998，63，： | 1 |
| 9 | Pancreatic hyperechogenicity associated with hypoadiponectinemia and insulin resistance: A Japanese population study显示文摘AIM To examine the relationship between pancreatic hyperechogenicity and risk factors for metabolic syndrome.METHODS A general population-based survey of lifestyle-related diseases was conducted from 2005 to 2006 in Japan. The study involved 551 participants older than 40 year of age. Data for 472 non-diabetic adults were included in the analysis. The measures included the demographic factors, blood parameters, results of a 75 g oral glucose tolerance test, and abdominal ultrasonography. The echogenicity of the pancreas and liver was compared, and then the subjects were separated into two groups: cases with pancreatic hyperechogenicity(n = 208) and cases without(controls, n = 264). The differences between both groups were compared using an unpaired t-test or Fisher's exact test. Multiple logistic regression analysis was used to determine the relationship between the pancreatic hyperechogenicity and clinical and bio-chemical parameters.RESULTS Subjects with pancreatic hyperechogenicity had decreased serum adiponectin concentration compared to control subjects [8.9(6.5, 12.8) vs 11.1(7.8, 15.9), P < 0.001] and more frequently exhibited features of metabolic syndrome. Logistic regression analysis showed that the following variables were significantly and independently associated with pancreatic hyperechogenicity: Presence of hypoadiponectinemia, increased body mass index(BMI), higher homeostasis model assessment of insulin resistance(HOMA-IR) score, and presence of fatty liver. Similar associations were also observed in subjects with pancreatic hyperechogenicity without fatty liver. Multivariate association analysis of data from participants without fatty liver showed that hypoadiponectinemia was significantly associated with pancreatic hyperechogenicity(OR = 0.93, 95%CI: 0.90- 0.97, P < 0.001). This association was independent of other confounding variables. Additionally, an increased BMI and higher HOMA-IR score were significantly associated with pancreatic hyperechogenicity.CONCLUSION Pancreatic hyperechogenicity is independently associated with increased BMI, insulin resistance, and hypoadiponectinemia in the general population. | Naohiko Makino Nakao Shirahata Teiichiro Honda Yoshiaki Ando Akiko Matsuda Yushi Ikeda Miho Ito Yuko Nishise Takafumi Saito Yoshiyuki Ueno Sumio Kawata | 2016 | World Journal of Hepatology2016，8，33： | 1 |
| 10 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 11 | Transmission of hepatitis C virus quasispecies between human adults显示文摘 | Takafumi Saito Hisayoshi Watanabe Li Shao Kazuo Okumoto Etsuko Hattori Mai Sanjo Keiko Misawa Akihiko Suzuki Tadashi Takeda Kazuhiko Sugahara Jun-itsu Ito Koji Saito Hitoshi Togashi Sumio Kawata | 2004 | Hepatology Research2004，，2： | 1 |
| 12 | Genetic variations in humans associated with differences in the course of hepatitis C显示文摘 | Takafumi Saito Guijin Ji Haruhide Shinzawa Kazuo Okumoto Etsuko Hattori Tohru Adachi Tadashi Takeda Kazuhiko Sugahara Jun-itsu Ito Hisayoshi Watanabe Koji Saito Hitoshi Togashi Keisuke Ishii Tadashi Matsuura Kiyoshi Inageda Masaaki Muramatsu Sumio Kawata | 2004 | Biochemical and Biophysical Research Communications2004，，2： | 1 |
| 13 | Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver显示文摘 | Kazuo Okumoto Takafumi Saito Hiroaki Haga Etsuko Hattori Rika Ishii Tetsuru Karasawa Akihiko Suzuki Keiko Misawa Mai Sanjo Jun-itsu Ito Kazuhiko Sugahara Koji Saito Hitoshi Togashi Sumio Kawata | 2006 | Journal of Gastroenterology2006，，1： | 1 |
| 14 | Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver显示文摘 | Kazuo Okumoto Takafumi Saito Hiroaki Haga Etsuko Hattori Rika Ishii Tetsuru Karasawa Akihiko Suzuki Keiko Misawa Mai Sanjo Jun-itsu Ito Kazuhiko Sugahara Koji Saito Hitoshi Togashi Sumio Kawata | 2006 | Journal of Gastroenterology2006，，1： | 1 |
| 15 | Effect of treatment with branched‐chain amino acids during sorafenib therapy for unresectable hepatocellular carcinoma显示文摘 | Haruhiko Takeda Hiroki Nishikawa Eriko Iguchi Yoshiaki Ohara Azusa Sakamoto Sumio Saito Norihiro Nishijima Akihiro Nasu Hideyuki Komekado Ryuichi Kita Toru Kimura Yukio Osaki | 2014 | Hepatol Res2014，，3： | 1 |
| 16 | Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver显示文摘 | Kazuo Okumoto Takafumi Saito Hiroaki Haga Etsuko Hattori Rika Ishii Tetsuru Karasawa Akihiko Suzuki Keiko Misawa Mai Sanjo Jun-itsu Ito Kazuhiko Sugahara Koji Saito Hitoshi Togashi Sumio Kawata | 2006 | Journal of Gastroenterology2006，，1： | 1 |
| 17 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 18 | Papillary-cystic neoplasm of the pancreas with multiple hepatic metastases: A case report显示文摘 | Yukihiko Matsuda M.D. Yasuharu Imai M.D. Sumio Kawata M.D. Masahiro Nishikawa M.D. Shio Miyoshi M.D. Ryuzo Saito M.D. Yuzo Minami M.D. Seiichiro Tarui M.D | 1987 | Gastroenterologia Japonica1987，，3： | 1 |
| 19 | Prior minimal endoscopic sphincterotomy to prevent pancreatitis related to endoscopic balloon sphincteroplasty显示文摘AIM To investigate the efficacy of prior minimal endoscopic sphincterotomy(EST) to prevent pancreatitis related to endoscopic balloon sphincteroplasty(EBS).METHODS After bile duct access was gained and cholangiogram confirmed the presence of stones < 8 mm in the common bile duct at endoscopic retrograde cholangiography, patients were subjected to minimal EST(up to one-third of the size the papilla) plus 8 mm EBS(ESTEBS group). The incidence of pancreatitis and the difference in serum amylase level after the procedure were examined and compared with those associated with 8-mm EBS alone in 32 patients of historical control(control group).RESULTS One hundred and five patients were included in the EST-EBS group, and complete stone removal was accomplished in all of them. The difference in serum amylase level after the procedure was- 25.0(217.9) IU/L in the EST-EBS group and this value was significantly lower than the 365.5(576.3) IU/L observed in the control group(P < 0.001). The incidence of post-procedure pancreatitis was 0%(0/105) in the EST-EBS group and 15.6%(5/32) in the control group(P < 0.001).CONCLUSION Prior minimal EST might be useful to prevent the elevation of serum amylase level and the occurrence of pancreatitis related to EBS. | Ryo Kanazawa Jin Kan Sai Tomoyasu Ito Hiroko Miura Shigeto Ishii Hiroaki Saito Ko Tomishima Ryo Shimizu Koki Sato Manabu Hayashi Sumio Watanabe Shuichiro Shiina | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 0 |
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