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| 1 | Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C显示文摘At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. | Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M Rosenberg | 2020 | World Journal of Gastroenterology2020，26，2： | 17 |
| 2 | Colorectal cancers in ulcerative colitis from a low-prevalence area for colon cancer显示文摘AIM: To determine the incidence and risk factors for colorectal cancer(CRC) in patients with ulcerative colitis from a low prevalence region for CRC.METHODS: Our prospective database yielded a cohort of 430 patients [age: 44 ± 14.6 years; 248 men(57.7%)] with ulcerative colitis(median disease duration 6, range: 1-39 years) for analysis. Of these, 131(30.5%) had left-sided colitis and 159(37%) extensive colitis. Patients with histologically confirmed CRC within the segment with colitis were compared with those without CRC, to determine the risk factors for the development of CRC.RESULTS: Twelve patients(2.8%) developed CRC. The overall incidence density was 3.56/1000 patient-years of disease- 3/1000 in the first 10 years, 3.3/1000 at 10 to 20 years, and 7/1000 at > 20 years. Three of our 12 patients developed CRC within 8 years of disease onset. On univariate analysis, extensive colitis, longer duration of disease, and poor control of disease were associated with development of CRC. On multivariate analysis, duration of disease and extent of colitis remained significant.CONCLUSION: CRC occurred in 2.8% of patients with ulcerative colitis in our population- an incidence density similar to that in Western countries in spite of a low overall prevalence of colon cancer in our population.The risk increased with extent and duration of disease. | Devendra Desai Sudeep Shah Abhijit Deshmukh Philip Abraham Anand Joshi Tarun Gupta Ramesh Deshpande Varun Khandagale Siji George | 2015 | World Journal of Gastroenterology2015，21，12： | 7 |
| 3 | Liver transplantation for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignancy of the liver. It usually occurs in the setting of chronic liver disease and has a poor prognosis if untreated. Orthotopic liver transplantation (OLT) is a suitable therapeutic option for early,unresectable HCC particularly in the setting of chronic liver disease. Following on from disappointing initial results,the seminal study by Mazzaferro et al in 1996 established OLT as a viable treatment for HCC. In this study,the 'Milan criteria' were applied achieving a 4-year survival rate similar to OLT for benign disease. Since then various groups have attempted to expand these criteria whilst maintaining long term survival rates. The technique of living donor liver transplantation has evolved over the past decade,particularly in Asia,and published outcome data is comparable to that of OLT. This article will review the evidence,indications,and the future direction of liver transplantation for liver cancer. | Sudeep Tanwar Shahid A Khan Vijay Paul Bob Grover Catherine Gwilt Belinda Smith Ashley Brown | 2009 | World Journal of Gastroenterology2009，15，44： | 4 |
| 4 | Two-dimensional MXenes:New frontier of wearable and flexible electronics显示文摘Wearable electronics offer incredible benefits in mobile healthcare monitoring,sensing,portable energy harvesting and storage,human-machine interactions,etc.,due to the evolution of rigid electronics structure to flexible and stretchable devices.Lately,transition metal carbides and nitrides(MXenes)are highly regarded as a group of thriving two-dimensional nanomaterials and extraordinary building blocks for emerging flexible electronics platforms because of their excellent electrical conductivity,enriched surface functionalities,and large surface area.This article reviews the most recent developments in MXene-enabled flexible electronics for wearable electronics.Several MXeneenabled electronic devices designed on a nanometric scale are highlighted by drawing attention to widely developed nonstructural attributes,including 3D configured devices,textile and planer substrates,bioinspired structures,and printed materials.Furthermore,the unique progress of these nanodevices is highlighted by representative applications in healthcare,energy,electromagnetic interference(EMI)shielding,and humanoid control of machines.The emerging prospects of MXene nanomaterials as a key frontier in nextgeneration wearable electronics are envisioned and the design challenges of these electronic systems are also discussed,followed by proposed solutions. | Abbas Ahmed Sudeep Sharma Bapan Adak Md Milon Hossain Anna Marie LaChance Samrat Mukhopadhyay Luyi Sun | 2022 | InfoMat2022，4，4： | 4 |
| 5 | Metastatic clear cell variant of hepatocellular carcinoma with an occult hepatic primary显示文摘Metastatic clear cell carcinomas are commonly seen in the kidney and lung. Clear cell variant of hepatocellular carci- noma is an uncommon tumour. Diagnosis is usually made by correlation of histopathology. tumour markers and im- munohistochemistry, especially HepPar 1. In this unusual case of metastatic clear cell carcinoma presenting as Sister Mary Joseph’s nodule, no primary evidence was observed radiologically in the liver, but the level of alfa fetoprotein was markedly elevated. Metastatic clear cell carcinoma of the liver with an occult hepatic primary was diagnosed by immunohistochemical profile of the tumour. | Samir ShahSamir Shah Sudeep Gupta Tanuja Shet Amita Maheshwari Rekha Wuntkal and Kunisshery Mallath Mohandas | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，2： | 3 |
| 6 | Efficacy of selective laser trabeculoplasty following incisional glaucoma surgery显示文摘AIM: To evaluate the efficacy of selective laser trabeculoplasty(SLT) in glaucomatous eyes with previous incisional glaucoma surgery. METHODS: A retrospective cohort of eyes that underwent SLT at a single institution from 2013-2015 were followed for 1 y. Reduction in intraocular pressure(IOP) following SLT was evaluated in eyes with prior trabeculectomy with Ex Press mini shunt(Alcon, Ft Worth, TX, USA), Ahmed valve(New World Medical, Cucamonga, CA, USA), or combined phacoemulsification-trabeculectomy. A control group was included with eyes without prior surgery that underwent SLT. Success was defined as >20% drop in IOP from pre-SLT baseline. RESULTS: One-hundred and six eyes were included with 53 in both the prior glaucoma surgery(PGS) and no prior glaucoma surgery(NPGS) groups. Mean pre-SLT IOP was 19.2±4.3 and 20.6±6.0 mm Hg for PGS and NPGS groups, respectively(P=0.17). Both groups produced statistically significant IOP reductions at 1 and 6 mo(P<0.04). At 6 mo, mean IOP reduction reached 7.3% and 10.8% for the PGS and NPGS groups, respectively(P=0.42). Overall, 27.9% and 31.7% of eyes in PGS and NPGS groups met success criteria at 1 y(P=0.70). In the PGS group, eyes with baseline IOP ≥21 mm Hg had IOP reductions of 18.1%(P<0.001), 16.7%(P<0.01), and 8.4%(P=0.31) compared to eyes with baseline IOP <21 mm Hg who had IOP reductions of 2.3%(P=0.39), 3.4%(P=0.19), and 1.1%(P=0.72) at 1, 6 mo, and 1 y, respectively. CONCLUSION: SLT is efficacious in eyes with prior incisional glaucoma surgery and results in similar IOP reductions compared to eyes without PGS. A larger IOP reduction is observed following SLT in eyes with higher pre-SLT IOP. | Robert Allan Sharpe Leah L Kammerdiener David B.Williams Sudeep K.Das Matthew J.Nutaitis | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 3 |
| 7 | 成年人无颜面部血管瘤斯特奇-韦伯综合征一例显示文摘斯特奇-韦伯综合征(Sturge-Weber syndrome,SWS)以一侧面部三叉神经分布区血管瘤、癫痫、智能减退、对侧偏瘫及青光眼为主要临床特征.本文报道一例成年首次发病的无颜面部血管瘤的SWS(SWSⅢ型)病例.37岁出现偏头痛后反复发作,47岁时首次癫痫发作,随后出现失语、左上肢软瘫;头颅CT显示右侧顶枕部钙化,CT血管成像显示右侧颞叶及枕叶血管畸形,MRI显示右侧大脑软脑膜强化明显.采用药物控制癫痫发作,其他症状也改善. | 张蓉 陈伟 胡强 Shrestha Sudeep | 2014 | 浙江大学学报(医学版)2014，43，5： | 3 |
| 8 | Validity of subjective assessment as screening tool for dry eye disease and its association with clinical tests显示文摘AIM: To determine the role of subjective assessment using Mc Monnies dry eye questionnaire in diagnosing dry eye disease and its association with clinical tests.METHODS: There were 500 patients screened for dry eye using Mc Monnies dry eye questionnaire between May to October 2013 at the outpatient Department of Ophthalmology of a medical college hospital. All 500 patients were subjected to clinical tests. Dry eye was defined as having one or more symptoms often or all the time. Positive signs were if one or both eyes revealed tear film breakup time(TBUT) of ≤10s, a Schirmer test score of ≤10 mm, a Rose Bengal staining score of ≥1, a Lissamine green staining score of ≥1 or existence of meibomian gland disease(≥grade 1). Statistical analysis was performed to describe the distribution of symptoms and signs, to assess the correlations between Mc Monnies score(MS) and variable clinical signs of dry eye, and to explore the association between dry eye symptoms and variable clinical signs. Analysis was performed using software package Epi info. A Probability(P) value using Chi-square test of <0.005 was taken as significant.· RESULTS: Dry eye prevalence with symptoms(questionnaire), Schirmer test, TBUT, Rose Bengal staining and Lissamine green staining was 25.6%,15.20%, 20.80%, 23.60%, and 22.60% respectively. Among those with severe symptoms(MS>20), 75.86% had a low TBUT(<10s), 58.62% had a low Schirmer's I test(≤10 mm),86.20% had Rose Bengal staining score of ≥1, 79.31%had Lissamine green staining score of ≥1. We found statistically significant associations between positive Schirmer test and arthritis(P <0.002), dryness elsewhere(P <0.001), contact lens use(P < 0.002), systemic medication(P <0.0001), sleeping with eyes partly open(P <0.002), history of dry eyes treatment(P <0.0001),environmental factors(P <0.001), swimming(P <0.001).· CONCLUSION: Subjective assessment plays an important role in diagnosing dry eye disease. There is strong correlation between MS and Schirmer test, TBUT,Rose Bengal staining and Lissamine green staining in normal as well as marginal and pathological dry eye. | Kavita R Bhatnagar Sonali Pote Sudeep Pujari Dhiraj Deka | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 2 |
| 9 | Effectiveness of seatbelts in mitigating traumatic brain injury severity显示文摘INTRODUCTION Over the past few decades,traumatic brain injuries(TBIs)have become one of the leading causes of death and the leading cause of injury-related death in the USA.[1,2]It is estimated that 1.70 million people are subject to TBIs each year.[2]Males are more likely to sustain TBIs(59%);the most common age groups are 0–5 years,15–19 years,and>65 years.[2]Approximately 1.36 million people present to the emergency department(ED),275,000 are admitted to the hospital,and 52,000 people die from TBIs.[2]The leading causes of TBIs are falling(35.2%),motor vehicle collisions(MVCs,17.3%),struck by/against an object(16.5%),and assault(10.0%).[2]These statistics combine to make TBIs the leading cause of injury-related death in the USA at 30.5%.[2]It has been estimated that,with specifi c guidelines from the Brain Trauma Foundation,up to 50.0%of the 52,000 TBIrelated deaths may be prevented.[3] | Latha Ganti Aakash NBodhit Yasamin Daneshvar Kelsey Hatchitt Sudeep Kuchibhotla Christa Pulvino Sarah WAyala Keith RPeters | 2021 | World Journal of Emergency Medicine2021，12，1： | 2 |
| 10 | Primary graft dysfunction following lung transplantation:From pathogenesis to future frontiers显示文摘Lung transplantation is the treatment of choice for patients with end-stage lung disease.Currently,just under 5000 lung transplants are performed worldwide annually.However,a major scourge leading to 90-d and 1-year mortality remains primary graft dysfunction.It is a spectrum of lung injury ranging from mild to severe depending on the level of hypoxaemia and lung injury post-transplant.This review aims to provide an in-depth analysis of the epidemiology,pathophysiology,risk factors,outcomes,and future frontiers involved in mitigating primary graft dysfunction.The current diagnostic criteria are examined alongside changes from the previous definition.We also highlight the issues surrounding chronic lung allograft dysfunction and identify the novel therapies available for ex-vivo lung perfusion.Although primary graft dysfunction remains a significant contributor to 90-d and 1-year mortality,ongoing research and development abreast with current technological advancements have shed some light on the issue in pursuit of future diagnostic and therapeutic tools. | Sanjeet Singh Avtaar Singh Sudeep Das De Ahmed Al-Adhami Ramesh Singh Peter MA Hopkins PhilipAlan Curry | 2023 | World Journal of Transplantation2023，13，3： | 2 |
| 11 | Boosting block truncation coding with kekre's LUV color space for image retrieval显示文摘 | Kekre H B Sudeep D Thepade | 2008 | International Journal of Electrical Computer and Systems Engineering2008，2，3： | 1 |
| 12 | Premature coronary artery disease in North India: an angiography study of 1971 patients 显示文摘 | Satyendra T Sudeep K Aditya K | 2005 | India Heart J2005，57，： | 1 |
| 13 | Chikungunya: an overview显示文摘 | A. B. Sudeep D. Parashar | 2008 | Journal of Biosciences2008，，： | 1 |
| 14 | Citalopram versus other antidepressants for late‐life depression: a systematic review and meta‐analysis显示文摘 | Dallas P.Seitz Sudeep S.Gill David K.Conn | 2010 | Int J Geriat Psychiatry2010，，12： | 1 |
| 15 | mpaired flow-mediated vasodilatation in Asian Indians with erectile dysfunction显示文摘Endothelial 机能障碍是在冠的动脉疾病(CAD ) 和可勃起的机能障碍(编辑) 之间的要求的连接。臂的动脉调停流动的 vasodilatation (FMD ) 是为 endothelial 功能评价的一个非侵略的代理人标记。尽管有代表可观的全球 CAD 负担的亚洲印第安人,在这些病人的 FMD 和编辑上的数据正在缺乏。经历冠的 angiography 的 225 个病人, 72 %有的编辑(使用可勃起的功能(IIEF-5 ) 问询表的国际索引估计) ;编辑对中等在 61 % 严重;病人。编辑病人有严重、弥漫的 angiographic CAD,包含的很多冠的容器和更低的吝啬的臂的动脉 FMD 的更高的发生(6.40 % ± 4.60 %对 9.10 % ± 4.87 %, P< 0.001 ) 与 non-ED 病人相比。在 FMD 的进步减小与增加编辑的严厉被注意损害 FMD (≤ 5.5 %) 两次在编辑病人同样普通(52 %对 24 %没有编辑) 。有损害 FMD 的病人有更高的编辑流行(85 %对 62 %) 并且更低的吝啬的 IIEF-5 与正常 FMD 与那些相比得分。损害 FMD 是另外的风险因素的一个重要编辑预言者独立人士(机会比率, 2.33;95 %信心间隔:0.59-9.23;P=0.03 ) 。在 FMD 和编辑严厉之间的反的关联被观察(r=− 0.22;P=0.004 ) 。编辑在有 angiographically 记录的 CAD 的亚洲印第安人之中是普通的。有编辑的病人损害了独立于另外的风险因素的 FMD,建议那个 endothelial 机能障碍是内在的 pathophysiology。泌尿科医师和心脏病专家需要知道在编辑, CAD 和 endothelial 机能障碍之间的协会。 | Tanuj Bhatia Aditya Kapoor Jatinder Kumar Archana Sinha Priyadarshi Ranjan Sudeep Kumar Naveen Garg Satyendra-Tewari Aneesh Srivastava Rakesh Kapoor Pravin K Goel | 2013 | Asian Journal of Andrology2013，15，5： | 1 |
| 16 | Transabdominal Extensive Esophagogastric Devascularization with Gastroesophageal Stapling for Management of Noncirrhotic Portal Hypertension: Long-term Results显示文摘 | Surendra K. Mathur Sudeep R. Shah Sanjay S. Nagral Zahir F. Soonawala | 1999 | World Journal of Surgery1999，，11： | 1 |
| 17 | BarnabasVictor, comparison and combination of ear and face ima-ges in appearance -based biometrics 显示文摘 | Kyong Chang Kevin W Bowyer Sudeep Sarkar | 2003 | IEEE Transac-tions on Pattern Analysis and Machine Intelligence2003，25，9： | 1 |
| 18 | Kinetically Trapped Co-continuous Polymer Morphologies Through Intraphase Ge- lation of Nanoparticles显示文摘 | Li L Miesch C Sudeep P K | 2011 | Nano Letters2011，115，： | 1 |
| 19 | Comparison of Edge Detectors显示文摘 | Mike Heath Sudeep Sarkar Thomas Sanocki Kevin Bowyer | 1998 | Computer Vision and Image Understanding1998，，1： | 1 |
| 20 | Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging显示文摘 | Sathya Prakash Manimunda Paluru Vijayachari Raghuraj Uppoor Attayur Purushottaman Sugunan Shiv Shankar Singh Subhodh Kumar Rai Anakkathil Balan Sudeep Nagarajan Muruganandam Itta Krishna Chaitanya Dev Reddy Guruprasad | 2010 | Transactions of the Royal Society of Tropical Medicine and Hygiene2010，，6： | 1 |
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