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| 1 | Risk factors for clinically significant macular edema in a multi-ethnics population with type 2 diabetes显示文摘·AIM:To determine the risk factors of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR) in a multi-ethnics Malaysian population. ·METHODS:We performed a case control study in which 150 patients with bilateral NPDR and CSME in either eye were compared to 150 patients with bilateral NPDR and no CSME in both eyes. CSME and NPDR were graded according to Early Treatment of Diabetic Retinopathy Study criteria. Student's t-test, odds ratio and multiple logistic regression analysis were performed to analyze the duration of diabetes, body mass index (BMI), blood pressure(BP), total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TG), fasting blood glucose (FBG), HbA1c, full blood count, serum creatinine and proteinuria between the two groups. ·RESULTS:Both groups were matched in terms of age, gender and ethnicity. Duration of diabetes, total serum cholesterol, serum LDL, FBG, HbA1c and serum creatinine were significantly higher in the CSME group (P <0.05). The hemoglobin, packed cell volume were significantly lower in the CSME group (P <0.05). There was no significant difference for serum HDL, TG, BMI, systolic and diastolic BP. Multiple logistic regression analysis showed that total serum cholesterol and HbA1c had significantly high odds of developing CSME. ·CONCLUSION:HbA1c and total cholesterol are the two most important risk factors associated with CSME in patients with NPDR. | Ong Ming Jew Mohammadreza Peyman Subrayan Visvaraja | 2012 | International Journal of Ophthalmology(English edition)2012,5,4: | 7 |
| 2 | 皮质类固醇治疗外伤性视神经病变的四天关键时期显示文摘目的:评估静脉注射甲基强的松龙(IVMP)对外伤性视神经病变患者的疗效。
方法:回顾性分析2000-01至2007-06我院收治的16例外伤性视神经病变(TON)患者的临床资料。1g甲基强的松龙分3d静脉应用,然后口服泼尼松龙11d,并逐渐减量。记录从损伤开始到治疗开始的时间。视力变化是本研究结果的主要功能评价指标。在入院时,治疗后1,2,3d;1wk和1mo时,分别记录最佳矫正视力(BCVA)。
结果:共有16例患者纳入本研究,平均年龄为30岁,其中男性14例、女性2例。引起TON的主要原因有摩托车事故(占69%),打架斗殴(占19%)和体育运动(占12%)。所有患者都表现有相对传入性瞳孔障碍。在损伤后4d内开始静脉注射甲基强的松龙,采用Snellen视力表检查视力,绝大部分(56%)患者视力提高超过3行或大于等于0.5(6/12)。在损伤后5d以上才开始用类固醇治疗,视力则没有任何进步。
结论:治疗TON,静脉注射中等到大剂量甲基强的松龙仍将起到重要作用。静脉注射甲基强的松龙治疗TON可能存在伤后4d的关键时期,超过了这个时期,该治疗可能就毫无效果。但还需要有更多的研究来为我们提供有明显统计学意义的数据。 | Soon Lek Yap Angeline Diong Ching Nga Nadir Ali Mohamed Ali Visvaraja Subrayan | 2008 | 国际眼科杂志2008,8,3: | 6 |
| 3 | 人工晶状体前表面非球面化改良能够改善视觉质量(英文)显示文摘目的:根据对比敏感度结果比较前表面改良的非球面Tecnis Z9000 IOL和标准的911A IOL的光学性能。方法:Tecnis Z9000硅凝胶IOL和911A IOL具有共同的基本特征包括12mm总长度、三片直边双凸6mm的光学直径和成角的聚丙乙烯C襻。对连续10例双侧白内障患者(20眼)进行了随机前瞻研究,所有患者都接受了白内障超声乳化手术并随机于1眼植入Tecnis Z9000 IOL,另1眼在术后6wk内植入911A IOL作为对照,术后6wk进行对比敏感度检查,所得数据采用秩和检验进行比较。结果:随机植入Tecnis IOL组的术前平均最佳Snellen矫正视力为6/8.5(0.70),植入911AIOL组为6/9.4(0.64),所有20眼术后最佳矫正视力都达到了6/6(1.0)。术后对比敏感度分析发现两组在12和18cpd(明视)、1.5和3cpd(暮视)以及1.5和3cpd(暮视伴眩光)均有统计学差异(P<0.05)结论:Tecnis Z9000 IOL被证明其对比敏感度在明视高空间频率和暮视低空间频率方面均显著优于911A IOL。 | V Subrayan E.Mavrikakis J.A.Bell | 2007 | 国际眼科杂志2007,7,4: | 4 |
| 4 | 玻璃体内注射曲安奈德治疗继发于IRVAN的黄斑水肿(英文)显示文摘目的:报告玻璃体内注射曲安奈德对特发性视网膜炎、血管炎、动脉瘤及视神经视网膜炎(IRVAN)所致的黄斑水肿的治疗效果。方法:病例报告。结果:患者诊断为特发性视网膜炎、血管炎、动脉瘤及视神经视网膜炎导致的伴有视力丧失的继发性黄斑水肿。玻璃体内注射曲安奈德后黄斑水肿减轻,视力显著改善。结论:以前的报告建议采取全视网膜光凝,玻璃体切除术及全身和眼部类固醇治疗。对于继发于IRVAN的黄斑水肿和血管炎,玻璃体内注射曲安奈德是一种安全有效的治疗方法。 | Terrence Kwong-Weng Soong Visvaraja Subrayan Choo May May | 2010 | 国际眼科杂志2010,10,11: | 4 |
| 5 | Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury显示文摘 | Sang-Bing Ong Sapna Subrayan Shiang Y. Lim Derek M. Yellon Sean M. Davidson Derek J. Hausenloy | 2010 | Circulation2010,,18: | 3 |
| 6 | 黄斑色素光学密度、中央黄斑厚度与体重指数的关系(英文)显示文摘目的:评估黄斑色素光学密度(MPOD)、中央黄斑厚度与体重指数(BMI)的关系。方法:这是一项在单一机构中进行比较的横断面研究。本研究共纳入210名符合入选标准的志愿者。使用黄斑色素筛选剂II对受试者MPOD进行测量。使用SD Cirrus OCT测量中央黄斑厚度。记录所有眼MPOD和OCT信息。使用Microsoft~?Excel,SPSS和R进行数据分析。结果:MPOD和中央黄斑厚度之间呈明显正相关(r=0.42,P<0.01)。同时,MPOD和BMI之间呈明显负相关(r=-0.23,P<0.01)。结论:研究得出,MPOD和中央黄斑厚度之间呈明显正相关。还需要进一步研究中央凹的详细结构及其与MPOD的关系。研究发现了MPOD与BMI之间呈明显正相关,且得出BMI的降低可能会增加黄斑色素的密度,这有助于预防年龄相关性黄斑变性(ARMD)。 | Lee Hong Nien Fazliana Ismail Rafidah Sudarno Angela Loo Voon Pei Visvaraja Subrayan | 2019 | 国际眼科杂志2019,19,5: | 3 |
| 7 | 玻璃体切割术联合人工晶状体巩膜固定术治疗眼外伤的疗效(英文)显示文摘目的:探讨玻璃体切割术(pars plana vitrectomy,PPV)联合人工晶状体(intraocular lens,IOL)巩膜固定术治疗眼外伤的疗效。方法:系列病例回顾性分析。将马来西亚大学医学中心接受PPV联合IOL巩膜固定术的8例连续性病例纳入研究,其中1例患者双眼均受伤,共有9眼。对现阶段视力,手术技巧,并发症及术后疗效进行分析。结果:9眼中有8眼(89%)视力提高。术后主要并发症是眼压升高,无缝线破裂。结论:PPV联合IOL巩膜固定术对有眼外伤病史的患者有非常好的疗效。 | Angela V PLoo Sujaya Singh Mohammadreza Peyman Visvaraja Subrayan | 2012 | 国际眼科杂志2012,12,6: | 2 |
| 8 | Inhibiting mitochondrial fission protects the heart against isehemia/reperfusion injury显示文摘 | Ong SB Subrayan S Lim SY | 2010 | Circulation2010,121,18: | 1 |
| 9 | Comparison of B-scan sonographic measurements of optic cup with fund us photographic measu-rements显示文摘 | Ali NA Subrayan V Reddy SC | | 0,,05: | 1 |
| 10 | Inhibiting mitochondrialfission protects the heart against ischemia/reperfusion injury 显示文摘 | Ong SB Subrayan S Lim SY | 2010 | Circulation2010,121,18: | 1 |
| 11 | An overview of materials composed of carbon and nitrogen显示文摘 | Subrayan R P Rasmussen P G | 1995 | Trends in Polymer Science1995,3,: | 1 |
| 12 | Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion iniury 显示文摘 | Ong SB Subrayan S Lim SY | 2010 | Circulation2010,121,18: | 1 |
| 13 | Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury显示文摘 | ONG S B SUBRAYAN S LIM S Y | 2010 | Circulation2010,121,18: | 1 |
| 14 | Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury 显示文摘 | Ong SB Subrayan S Lim SY | 2010 | Circulation2010,121,18: | 1 |
| 15 | Inhibiting mitochon- drial fission protects the heart against ischemia/reperfu- sion injury 显示文摘 | Ong SB Subrayan S Lin~ SY | 2010 | Circulation2010,121,18: | 1 |
| 16 | An overview of materials composed of carbon and nitrogen显示文摘 | SUBRAYAN R P RASMUSSEN P G | 1995 | Trends in polymer science1995,3,: | 1 |
| 17 | Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury 显示文摘 | Ong SB Subrayan S Lira SY ct al | 2010 | Circulation2010,121,18: | 1 |
| 18 | Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury显示文摘 | Ong S B Subrayan S Lim S Y | 2010 | Circulation2010,121,: | 1 |
| 19 | Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury显示文摘 | ONG S B SUBRAYAN S LIM S Y | 2010 | Circulation2010,121,18: | 1 |
| 20 | Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury显示文摘 | Ong SB Subrayan S Lira SY | 2010 | Circulation2010,121,18: | 1 |