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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 3 | Primary pediatric mid-brain lymphoma:Report of a rare pediatric tumor in a rare location显示文摘Primary central nervous system lymphoma(PCNSL) is a rare disease in pediatric age group. A thirteen-yearold male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation. The patient was alive without disease 12 mo after completion of treatment. This case highlights importance of keeping PCNSL as differential in brain stem lesions of pediatric patients also. Radiation and chemotherapy remains the most important treatment for such patients. | Rony Benson Supriya Mallick Suvendu Purkait Vaishali Suri K P Haresh Subhash Gupta Dayanand Sharma Pramod Kumar Julka Goura Kishore Rath | 2016 | World Journal of Clinical Cases2016，4，12： | 2 |
| 4 | Changes in blue-green and chlorophyll fluorescence emission and fluorescence ratios during senescence of tobacco plants显示文摘 | Subhash N Wenzel O Lichtenthaler H K | 1999 | Remote Sensing of Environment1999，69，： | 1 |
| 5 | Effects of cell shape and cell wall thickness variations on the elastic properties of two- dimensional cellular solids显示文摘 | Li K Gao X L Subhash G | 2005 | International Journal of Solids and Structures2005，42，5： | 1 |
| 6 | Geography of Venture Capital Financing:A Global Perspective显示文摘 | | 2007 | Journal of Wealth Management2007，9，4： | 1 |
| 7 | Tobacco Rattle Virus Vector: A Rapid and Transient Means of SilencingManduca sexta Genes by Plant Mediated RNA Interference显示文摘 | Pavan K Sagar Subhash P Ian T B | 2012 | PLoS ONE2012，7，31： | 1 |
| 8 | Determination of lectin in very dilute solution with umbelliferyl sugars by fluorescence quenching 显示文摘 | Pradip K Datta Subhash Ch Bera | 1989 | Analytica Chimica Acta1989，220，： | 1 |
| 9 | Effect of mulch and irrigation on tuber size, canopy temperature, water use and yield of potato: Solanum tuberosum显示文摘 | Chandra Subhash Singh R D Bhatnagar V K | 2002 | Indian Journal of Agronomy2002，47，3： | 1 |
| 10 | Epstein- barr virus protein can upregulate cyclo-oxygenase-2 expression through association with the suppressor of metastasis Nm23-H1显示文摘 | RAJEEV K SUBHASH C VERMA | 2006 | J Virol2006，80，： | 1 |
| 11 | Is basiliximab induction, a novel risk factor for new onset diabetes after transplantation for living donor renal allograft recipients?显示文摘 | Narayan Prasad Desraj Gurjer Dharmender Bhadauria Amit Gupta Aneesh Srivastava Anupama Kaul Akhilesh Jaiswal Brijesh Yadav Subhash Yadav Raj K Sharma | 2014 | Nephrology2014，，4： | 1 |
| 12 | Mechanics of Materials显示文摘 | Meyers M A Subhash G Kad B K | 1994 | 17: 1751994，17，： | 1 |
| 13 | Evaluation of cyclic hot corrosion behavior of detonation gun sprayed Cr3C2-25% NiCr coatings on nickel-and iron-based superalloys 显示文摘 | Subhash K Jayaganthan R Satya P | 2009 | Surface & Coatings Technology2009，203，8： | 1 |
| 14 | Biodegradable polymeric nanoparticles based drug delivery systems 显示文摘 | Avnesh K Sudesh KY Subhash CY | 2010 | Colloids and Sur- faces B : B iointerfaces2010，75，1： | 1 |
| 15 | Transition metal complexes of semicarbazones and thiosem icarbazones 显示文摘 | Subhash P George B K | 1985 | Coordination Chemistry Reviews1985，63，： | 1 |
| 16 | Sex detection of Carica papaya and Cycascircinalis in pre-flowering stage by ISSR and RAPD 显示文摘 | Gaurab G Subhash K R Kaushik G | 2007 | Current Science2007，92，4： | 1 |
| 17 | Structural,dielectric and magnetic properties of NiCuZn ferrite grown by citrate precursor method显示文摘 | MUKESH C D VERM A A SUBHASH C K | | 0，，： | 1 |
| 18 | Measuring dimensions of manufacturing flexibility显示文摘 | Lori L Koste Manoj K Malhotra Subhash Sharma | 2004 | Journal of Operations Management2004，22，2： | 1 |
| 19 | Evolution of mi- crostructure and shear-band formation in α-hep titanium 显示文摘 | Meyers M A Subhash G Kad B K | 1994 | Mech Mater1994，17，23： | 1 |
| 20 | Laser-induced damage to spray pyrolysis deposited transparent conducting films显示文摘 | Radhakrishnan P Sathianandan K Subhash N | 1986 | J Appl Phys1986，59，3： | 1 |
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