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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Influence of Rotational Speed on Microstructure and Mechanical Properties of Dissimilar Metal AISI 304-AISI 4140 Continuous Drive Friction Welds显示文摘Fundamental investigation of continuous drive friction welding of austenitic stainless steel (AISI 304) and low alloy steel (AISI 4140) is described. The emphasis is made on the influence of rotational speed on the microstructure and mechanical properties such as hardness, tensile strength, notch tensile strength and impact toughness of the dissimilar joints. Hardness profiles across the weld show the interface is harder than the respective parent metals. In general, maximum peak hardness is observed on the stainless steel side, while other peak hardness is on the low alloy steel side. A trough in hardness distribution in between the peaks is located on the low alloy steel side. Peak hardness on the stainless steel and low alloy steel side close to the interface increases with a decrease in rotational speed. All transverse tensile joints fractured on stainless steel side near the interface. Notch tensile strength and impact toughness increase with increase in rotational speed up to 1 500 r/min and decrease thereafter. The mechanism of influence of rotational speed for the observed trends is discussed in the torque, displacement characteristics, heat generation, microstructure, fractography and mechanical properties. | G Subhash Chander G Madhusudhan Reddy A Venugopal Rao | 2012 | Journal of Iron and Steel Research(International)2012，19，10： | 2 |
| 3 | Critical Appraisal of Limiting Strain Rates for CompressionTesting of Ceramics in a Split Hopkinson Pressure Bar显示文摘 | Subhash G | 1994 | American Ceramic Society1994，77，1： | 1 |
| 4 | A mieromeehanieal mod- el for high-strain rate behavior of eeramies显示文摘 | Raviehandran G Subhash G | 1995 | Inter- national Journal of Solids and Structures1995，32，1718： | 1 |
| 5 | Effects of cell shape and cell wall thickness variations on the elastic properties of two- dimensional cellular solids显示文摘 | Li K Gao X L Subhash G | 2005 | International Journal of Solids and Structures2005，42，5： | 1 |
| 6 | Cortisol promotes and integrates the osmotic competence of the organs in North African catfish (Clarias gariepinus Burchell): Evidence from in vivo and in situ approaches显示文摘 | Babitha G S Subhash P M C | 2010 | General and Comparative Endocrinology2010，168，1： | 1 |
| 7 | Critical appraisal of limiting strain rates for compression testing of ceramics in a split Hopkinson pressure bar显示文摘 | Ravichandran G Subhash G | 1994 | J Am Ceram Soc1994，77，1： | 1 |
| 8 | Critical appraisal oflimiting strain rates for compression testing of ceramics in a splitHopkinson pressure bar 显示文摘 | RAVICHANDRAN G SUBHASH G | 1994 | Journal of the American CeramicSociety1994，77，1： | 1 |
| 9 | Critical appraisal of limiting strain rates for compression testing of ceramics in a split Hopkinson pressure bar显示文摘 | Ravichandran G Subhash G | 1994 | Journal of the American Ceramic Society1994，77，1： | 1 |
| 10 | Critical Appraisal of Limiting Strain Rates for Compression Testing of Ceramics in a Split Hopkinson Pressure Bar显示文摘 | Ravichandran G Subhash G | 1994 | Journal of American Ceramic Society1994，77，： | 1 |
| 11 | Characteristics of Residual Plastic Zone under Static and Dynamic Vickers Indentations显示文摘 | KoePPel B J Subhash G | 1999 | Wear1999，224，： | 1 |
| 12 | Influence of lateral confinement on dynamic damage evolution during uniaxial compressive response of brittle solids显示文摘 | HUANG Cheng-yi Subhash G | 2003 | Journal of the Mechanics and Physics of Solids2003，51，： | 1 |
| 13 | Critical appraisal of limiting strain rates for compression testing of ceramics in a split Hopkinson pressure bar显示文摘 | RAVICHANDRAN G SUBHASH G | 1994 | Journal of the American Ceramic Society1994，77，1： | 1 |
| 14 | A dynamic damage growth model for uniaxial compressive response of rock aggregates显示文摘 | Huang C Y Subhash G | | 0，，05： | 1 |
| 15 | Dynamic Vickers Indentation of Brittle Ma- terials显示文摘 | Anton R J Subhash G | 2000 | Wear2000，239，： | 1 |
| 16 | A Computational Approach for the Classification of FEM Axisymmetric Stress as per ASME Code显示文摘 | Narasaiah G L Subhash G | 1986 | Pressure Vessel and Piping Technology1986，109，： | 1 |
| 17 | A dynamic dam- age growth model for uniaxial compressive responseof rock aggregates显示文摘 | Huang C Y Subhash G Vitton S J | 2002 | Mechanics of Materials2002，34，5： | 1 |
| 18 | A phenomenoIogical constitutive model for foams under large deformation显示文摘 | Liu Q Subhash G | 2004 | Polymer Engineering and Science2004，44，5： | 1 |
| 19 | Influence of lateral confine ment on dynamic damage evolution during uniaxial compressive response of brittle solids 显示文摘 | Huang C Y Subhash G | 2003 | Journal of the Mechanics and Physics of Solids2003，51，6： | 1 |
| 20 | Critical appraisal of limiting strain rates for compression testing of ceramics in a split Hopkinson pressure bar显示文摘 | Ravichandran G Subhash G | 1994 | Journal of American Ceramic Society1994，77，1： | 1 |
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