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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 3 | Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs显示文摘For human immunodeficiency virus(HIV)-infected patients, the 1990s were marked by the introduction of highly active antiretroviral therapy(HAART) representing a new perspective of life for these patients. The use of HAART was shown to effectively suppress the replication of HIV-1 and dramatically reduce mortality and morbidity, which led to a better and longer quality of life for HIV-1-infected patients. Apart from the substantial benefits that result from the use of various HAART regimens, laboratory and clinical experience has shown that HAART can induce severe and considerable adverse effects related to metabolic complications of lipid metabolism, characterized by signs of lipodystrophy, insulin resistance, central adiposity, dyslipidemia, increased risk of cardiovascular disease and even an increased risk of atherosclerosis. New drugs are being studied, new therapeutic strategies are being implemented, and the use of statins, fibrates, and inhibitors of intestinal cholesterol absorption have been effective alternatives. Changes in diet and lifestyle have also shown satisfactory results. | Joel da Cunha Luciana Morganti Ferreira Maselli Ana Carolina Bassi Stern Celso Spada Sérgio Paulo Bydlowski | 2015 | World Journal of Virology2015，4，2： | 9 |
| 4 | 金刚石中硫同位素组成揭示大陆形成过程的差异性显示文摘厚的岩石圈地幔的出现使得地球古老大陆变得稳定,然而关于这些古老大陆岩石圈地幔的形成却存在不同的成因解释。一些学者认为古老的大陆岩石圈地幔可通过俯冲洋壳平流增厚或堆叠等水平构造过程形成,而其他学者则认为地幔柱增生、海洋高原基底的熔融或地幔柱熔融残留物的底辟作用等垂向构造过程,在古老大陆岩石群地幔的形成过程中扮演了重要角色。目前,关于最早岩石圈的形成是通过水平还是垂向增生方式完成依然存在很大的争议,而不同的增生模式对于理解地球早期演化和板块作用的起始时限具有完全不同的意义。 | Smit K V Shirey S B Hauri E H Stern R A 袁超 | 2019 | 矿物岩石地球化学通报2019，38，5： | 5 |
| 5 | Incidence of Clostridium perfringens in broiler chickens and their environment during production and processing显示文摘 | CRAVEN S E STERN N J BAILEY J S | 2001 | Avian Dis2001，45，： | 1 |
| 6 | Assessing Reseller Performance from the Perspective of the Supplier显示文摘 | KUMAR N STERN L W ACHROL R S | 1992 | Journal of Marketing Research1992，29，5： | 1 |
| 7 | Event-related potentials as an index of cognitive function during recovery from severe closed head injury显示文摘 | Keren O Ben-Dror S Stern MJ | 1998 | J Head Trauma Rehabil(S0885-9701)1998，13，3： | 1 |
| 8 | The determinants of national innovative capacity显示文摘 | FurmanJ L Porter ME Stern S | 2002 | Research Policy2002，31，6： | 1 |
| 9 | Treatment of B-lymphoproliferative disorder with a monoclonal anti-interlenkin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial显示文摘 | Haddad E Paezesny S Leblond V Seigneurin JM Stern M Achkar A | 2001 | Blood2001，97，6： | 1 |
| 10 | Maintenance and re- lapse after weight loss in women:Behavioral aspects显示文摘 | KAYMAN S BRUVOLD W STERN J S | 1990 | Am Jf Clinical Nutrit1990，52，： | 1 |
| 11 | The Determinants of National Innovative Capacity显示文摘 | FURMAN J L PORTER M E STERN S | 2002 | Research Policy2002，31，8： | 1 |
| 12 | Bilateral intralobar pulmonary sequestration in a newborn, case report and review of the literature on bilateral pulmonary sequestrations显示文摘 | Stern R Berger S Casauha C | 2007 | J Pediatr Surg2007，42，4： | 1 |
| 13 | Mushrooms,Tumors, and Irnmunily 显示文摘 | Borchers A T Stern J S Hanckman R M | 1999 | Proceedings of the Society for Experimental Biology and Medicine1999，221，： | 1 |
| 14 | Influence of activation state of ErbB - 2 ( HER - 2 ) on response to adjuvant cyclophosphamide, doxo- rubicin,and fluorouracil for stage Ⅱ, node -positive breast cancer: study 8541 from the Cancer and Leukemia Group B显示文摘 | DiGiovanna MP Stern DF Edgerton S | 2008 | J Clin Oncol2008，26，14： | 1 |
| 15 | Structure/permeability relationships of siliconcontaining polyimides显示文摘 | Stern S A Vaidyanathan R | 1990 | Journal of Membrane Science1990，49，1： | 1 |
| 16 | Electrodeposition of tantalum carbide coatings from molten salts显示文摘 | Stern K H Gadomski S T | 1983 | J Electrochem Soc1983，130，2： | 1 |
| 17 | The determinants of national innovative capacity显示文摘 | FURMAN JL PORTER E STERN S | | 0，，： | 1 |
| 18 | The determinants of national innovative capacity 显示文摘 | Furman J J Porter M E Stern S | 2002 | Research Policy2002，，31： | 1 |
| 19 | Water births compared with land births an observation study of nine years显示文摘 | Geissbuehler V Stern S Eberhand J | 2004 | J Perinat Med2004，32，4： | 1 |
| 20 | The determinants of national innovative capacity 显示文摘 | Furman J L Porter M E Stern S | 2002 | Research Policy2002，31，6： | 1 |
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