|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Air/CO2 cooling garment: Description and benefits of use for subjects exposed to a hot and humid climate during physical activities显示文摘The severity of the hot and humid conditions to which miners are exposed increases as the depth of the work site increases.This can cause heat stress that can greatly affect the health and safety of workers.To resolve this,a cooling garment has been developed that uses an atmospheric discharge of liquid CO2 to create a cool microclimate with an average temperature of 12.5(±0.4)℃ beneath the garment.To evaluate the garment's cooling efficiency,19 male subjects participated in an experimental procedure.The two modes,cooling on and off,were compared.Significant physiological differences were found between the two modes after minute 27(p<0.05)until the end of the recovery phase for the heart rate(maximum difference of 10 beats per minute)and the internal body temperature(maximum difference of 0.33℃).It was found that the modes also affected the subjects'perceptions.The ON-mode was associated with better well-being and thermal comfort,and reduced humidity sensation.Perceptions of exertion were lower in the ON-mode condition from minute 2.The findings provide strong evidence of the ability of this cooling garment to reduce heat stress in hot and humid conditions similar to those encountered in deep mines. | Chady Al Sayed Ludwig Vinches Olivier Dupuy Wafa Douzi Benoit Dugue Stephane Halle | 2019 | International Journal of Mining Science and Technology2019，29，6： | 10 |
| 2 | The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells显示文摘 | Andrea Rückle Emanuel Haasbach Ilkka Julkunen Oliver Planz Christina Ehrhardt Stephan Ludwig | 2012 | Journal of Virology2012，，18： | 1 |
| 3 | The influenza virus PB1-F2 protein has interferon antagonistic activity显示文摘 | Sabine E. Dudek Ludmilla Wixler Carolin Nordhoff Alexandra Nordmann Darisuren Anhlan Viktor Wixler Stephan Ludwig | 2011 | Biological Chemistry2011，，12： | 1 |
| 4 | Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria显示文摘 | Michaela Aichler Mareike Elsner Natalie Ludyga Annette Feuchtinger Verena Zangen Stefan K Maier Benjamin Balluff Cédrik Sch?ne Ludwig Hierber Herbert Braselmann Stephan Meding Sandra Rauser Hans Zischka Michaela Aubele Manfred Schmitt Marcus Feith Stefani | 2013 | J Pathol2013，，4： | 1 |
| 5 | Location of liver metastases reflects the site of the primary colorectal carcinoma显示文摘 | Ralf Konopke Marius Distler Stefan Ludwig Stephan Kersting | 2008 | Scandinavian Journal of Gastroenterology2008，，2： | 1 |
| 6 | Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3显示文摘 | Christina Ehrhardt Christian Kardinal Walter J. Wurzer Thorsten Wolff Christoph von Eichel-Streiber Stephan Pleschka Oliver Planz Stephan Ludwig | 2004 | FEBS Letters2004，，： | 1 |
| 7 | Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria显示文摘 | Michaela Aichler Mareike Elsner Natalie Ludyga Annette Feuchtinger Verena Zangen Stefan K Maier Benjamin Balluff Cédrik Sch?ne Ludwig Hierber Herbert Braselmann Stephan Meding Sandra Rauser Hans Zischka Michaela Aubele Manfred Schmitt Marcus Feith Stefani | 2013 | J Pathol2013，，4： | 1 |
| 8 | Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury显示文摘 | Susanne Herold Stephan Ludwig Stephan Pleschka Thorsten Wolff | 2012 | Journal of Leukocyte Biology2012，，： | 1 |
| 9 | MEK-specific inhibitor U0126 blocks spread of borna disease virus in cultured cells 显示文摘 | OLIVER PLANZE STEPHAN PLESCHKA STEPHAN LUDWIG | 2001 | J Viro2001，75，： | 1 |
| 10 | Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis显示文摘 | Thiago D. Corrêa Madhusudanarao Vuda Annika Reintam Blaser Jukka Takala Siamak Djafarzadeh Martin W. Dünser Eliézer Silva Michael Lensch Ludwig Wilkens Stephan M. Jakob | 2012 | Critical Care Medicine2012，，10： | 1 |
| 11 | Optoacoustic microscopy at multiple discrete frequencies显示文摘Optoacoustic(photoacoustic)sensing employs illumination of transient energy and is typically implemented in the time domain using nanosecond photon pulses.However,the generation of high-energy short photon pulses requires complex laser technology that imposes a low pulse repetition frequency(PRF)and limits the number of wavelengths that are concurrently available for spectral imaging.To avoid the limitations of working in the time domain,we have developed frequency-domain optoacoustic microscopy(FDOM),in which light intensity is modulated at multiple discrete frequencies.We integrated FDOM into a hybrid system with multiphoton microscopy,and we examine the relationship between image formation and modulation frequency,showcase high-fidelity images with increasing numbers of modulation frequencies from phantoms and in vivo,and identify a redundancy in optoacoustic measurements performed at multiple frequencies.We demonstrate that due to high repetition rates,FDOM achieves signal-to-noise ratios similar to those obtained by time-domain methods,using commonly available laser diodes.Moreover,we experimentally confirm various advantages of the frequency-domain implementation at discrete modulation frequencies,including concurrent illumination at two wavelengths that are carried out at different modulation frequencies as well as flow measurements in microfluidic chips and in vivo based on the optoacoustic Doppler effect.Furthermore,we discuss how FDOM redefines possibilities for optoacoustic imaging by capitalizing on the advantages of working in the frequency domain. | Stephan Kellnberger Dominik Soliman George J.Tserevelakis Markus Seeger Hong Yang Angelos Karlas Ludwig Prade Murad Omar Vasilis Ntziachristos | 2018 | Light(Science & Applications)2018，7，1： | 0 |
| 12 | MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination显示文摘Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and mortality.There remains a medical need for vaccines against these pathogens.CMV(cytomegalovirus)is aβ-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8+T cells are maintained for a lifetime.Hence,CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous pathogens.We generated two recombinant murine CMV(MCMV)vaccine vectors expressing hemagglutinin(HA)of influenza A virus(MCMV^(HA))or the spike protein of severe acute respiratory syndrome coronavirus 2(MCMV^(S)).A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses,which strengthened over time.Importantly,MCMV^(HA)-vaccinated mice were protected from illness following challenge with the influenza virus,and we excluded that this protection was due to the effects of memory T cells.Conclusively,we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens. | Yeonsu Kim Xiaoyan Zheng Kathrin Eschke M.Zeeshan Chaudhry Federico Bertoglio Adriana Tomić Astrid Krmpotić Markus Hoffmann Yotam Bar-On Julia Boehme Dunja Bruder Thomas Ebensen Linda Brunotte Stephan Ludwig Martin Messerle Carlos Guzman Ofer Mandelboim Michael Hust Stefan Pöhlmann Stipan Jonjić LukaČičin-Šain | 2022 | Cellular & Molecular Immunology2022，19，2： | 0 |
| 13 | Direct nanoscopic observation of plasma waves in the channel of a graphene field-effect transistor显示文摘Plasma waves play an important role in many solid-state phenomena and devices.They also become significant in electronic device structures as the operation frequencies of these devices increase.A prominent example is field-effect transistors(FETs),that witness increased attention for application as rectifying detectors and mixers of electromagnetic waves at gigahertz and terahertz frequencies,where they exhibit very good sensitivity even high above the cut-off frequency defined by the carrier transit time.Transport theory predicts that the coupling of radiation at THz frequencies into the channel of an antenna-coupled FET leads to the development of a gated plasma wave,collectively involving the charge carriers of both the two-dimensional electron gas and the gate electrode.In this paper,we present the first direct visualization of these waves.Employing graphene FETs containing a buried gate electrode,we utilize near-field THz nanoscopy at room temperature to directly probe the envelope function of the electric field amplitude on the exposed graphene sheet and the neighboring antenna regions.Mapping of the field distribution documents that wave injection is unidirectional from the source side since the oscillating electrical potentials on the gate and drain are equalized by capacitive shunting.The plasma waves,excited at 2 THz,are overdamped,and their decay time lies in the range of 25-70 fs.Despite this short decay time,the decay length is rather long,i.e.,0.3-0.5μm,because of the rather large propagation speed of the plasma waves,which is found to lie in the range of 3.5-7×10^(6)m/s,in good agreement with theory.The propagation speed depends only weakly on the gate voltage swing and is consistent with the theoretically predicted 1/4 power law. | Amin Soltani Frederik Kuschewski Marlene Bonmann Andrey Generalov Andrei Vorobiev Florian Ludwig Matthias M.Wiecha Dovile Cibiraite Frederik Walla Stephan Winnerl Susanne C.Kehr Lukas M.Eng Jan Stake Hartmut G.Roskos | 2020 | Light(Science & Applications)2020，9，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员