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| 1 | Helicobacter pylori and oral pathology:Relationship with the gastric infection显示文摘Helicobacter pylori(H.pylori)has been found in the oral cavity and stomach,and its infection is one of the most frequent worldwide.We reviewed the literature and conducted a Topic Highlight,which identified studies reporting an association between H.pylori-infection in the oral cavity and H.pylori-positive stomach bacterium.This work was designed to determine whether H.pylori is the etiologic agent in periodontal disease,recurrent aphthous stomatitis(RAS),squamous cell carcinoma,burning and halitosis.Record selection focused on the highest quality studies and meta-analyses.We selected 48 articles reporting on the association between saliva and plaque and H.pylori-infection.In order to assess periodontal disease data,we included 12 clinical trials and 1 meta-analysis.We evaluated 13 published articles that addressed the potential association with RAS,and 6 with squamous cell carcinoma.Fourteen publications focused on our questions on burning and halitosis.There is a close relation between H.pylori infection in the oral cavity and the stomach.The mouth is the first extra-gastric reservoir.Regarding the role of H.pylori in the etiology of squamous cell carcinoma,no evidence is still available. | Isabel Adler Andrea Muio Silvia Aguas Laura Harada Mariana Diaz Adriana Lence Mario Labbrozzi Juan Manuel Muio Boris Elsner Alejandra Avagnina Valeria Denninghoff | 2014 | World Journal of Gastroenterology2014，20，29： | 21 |
| 2 | IMPROVING EIGENVECTORS IN ARNOLDI'S METHOD显示文摘The Ritz vectors obtained by Arnoldi’s method may not be good approxima- tions and even may not converge even if the corresponding Ritz values do. In order to improve the quality of Ritz vectors and enhance the efficiency of Arnoldi type algorithms, we propose a strategy that uses Ritz values obtained from an m-dimensional Krylov subspace but chooses modified approximate eigenvectors in an (m + 1)-dimensional Krylov subspace. Residual norm of each new approximate eigenpair is minimal over the span of the Ritz vector and the (m+1)th basis vector, which is available when the m-step Arnoldi process is run. The resulting modi- fied m-step Arnoldi method is better than the standard m-step one in theory and cheaper than the standard (m + 1)-step one. Based on this strategy, we present a modified m-step restarted Arnoldi algorithm. Numerical examples show that the modified m-step restarted algorithm and its version with Chebyshev acceleration are often considerably more efficient than the standard (m+ 1)-step restarted ones. | Zhong-xiao Jia (Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, China) Ludwig Elsner (Fakultat fur Mathematik, University Bielefeld, Postfach 100131, 33501 Bielefeld,Germany) | 2000 | Journal of Computational Mathematics2000，18，3： | 4 |
| 3 | Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease显示文摘Parkinson's disease is a neurodegenerative disease.Oxidative stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this disease.Physical exercise can regulate oxidative stress.The purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's disease.The aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise program.Our results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's disease.Compared with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session.Our results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme activity.These results could better help understand the target of oxidative stress in Parkinson's disease.This study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK). | Caroline Dani Isabel Teixeira Proenca Jessica Marinho Pamela Peccin Ivy Reichert Vital da Silva Simone Nique Vera Striebel Daniela Pochmann Viviane Rostirola Elsner | 2020 | Neural Regeneration Research2020，15，11： | 4 |
| 4 | Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring显示文摘It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear. | Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe Mega Gabriela dos Santos Salvalaggio Matilde Achaval Viviane Rostirola Elsner Simone Marcuzzo | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 5 | 直肠癌切除术后2周和12周临时性回肠造口关闭对比:来自前瞻性多中心随机对照研究的警示显示文摘背景:低位前切除术后临时性回肠造口关闭的最佳时机仍然是未能明确的。目的:本研究旨在对早期(2周)和晚期(12周)造口关闭进行比较。设计:平行、多中心、随机、对照临床研究。设置:该研究在3家瑞士医院开展。患者:因癌症而接受低位前切除术和临时性回肠造口术的患者。干预:患者被随机分配至早期关闭组或晚期关闭组。在造口关闭之前,对结肠吻合的完整性进行检查。 | 马志明 ELSNER A BROSI P WALENSI M | 2021 | 结直肠肛门外科2021，27，5： | 3 |
| 6 | Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study显示文摘A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of stroke.Thus,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these patients.Physical exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different populations.However,little is reported on this in post-stroke patients.The purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke individuals.In this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and post-intervention.After intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone group.There was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES groups.After intervention,a better cognitive performance was found in both groups compared with before the intervention.After intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone group.In addition,the intervention induced lower levels of lipid peroxidation.After intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the EXE group alone.In each group,both histone deacetylase(HDAC2)and histone acetyltransferase activities were increased after intervention compared with before the intervention.These findings suggest that a single exercise session with WalkAide FES is more effective on balance ability and cognitive performance compared with conventional exercise alone in post-stroke patients.This is likely to be related to the regulation of oxidative stress markers.The present study was approved by the Research Ethics Committee of the Methodist University Center-IPA(approval No.2.423.376)on December 7,2017 and registered in the Brazilian Registry of Clinical Trials—ReBEC(RBR-9phj2q)on February 11,2019. | Viviane Rostirola Elsner Lucieli Trevizol Isadora de Leon Marcos da Silva ThaynáWeiss Milena Braga Daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio | 2021 | Neural Regeneration Research2021，16，5： | 3 |
| 7 | Distinct antifibrogenic effects of erlotinib,sunitinib and sorafenib on rat pancreatic stellate cells显示文摘AIM:To study if three clinically available small molecule kinase inhibitors(SMI),erlotinib,sunitinib and sorafenib,exert antifibrogenic effects on pancreatic stellate cells(PSC)and analyze the basis of their action.METHODS:Cultured rat PSC were exposed to SMI.Cell proliferation and viability were assessed employing 5-bromo-2’-deoxyuridine incorporation assay and flow cytometry,respectively.2-Deoxy-2-[18F]fluoroglucose(18F-FDG)uptake was measured to study metabolic activity.Exhibition of the myofibroblastic PSC phenotype was monitored by immunofluorescence analysis ofα-smooth muscle actin(α-SMA)expression.Levels of mRNA were determined by real-time PCR,while protein expression and phosphorylation were analyzed by immunoblotting.Transforming growth factor-β1 (TGF-β1)levels in culture supernatants were quantified by ELISA.RESULTS:All three SMI inhibited cell proliferation and18F-FDG uptake in a dose-dependent manner and without significant cytotoxic effects.Furthermore,additive effects of the drugs were observed.Immunoblot analysis showed that sorafenib and sunitib,but not erlotinib,efficiently blocked activation of the AKT pathway,while all three drugs displayed little effect on phosphorylation of ERK1/2.Cells treated with sorafenib or sunitinib expressed less interleukin-6 mRNA as well as less collagen type 1 mRNA and protein.Sorafenib was the only drug that also upregulated the expression of matrix metalloproteinase-2 and reduced the secretion of TGF-β1 protein.All three drugs showed insignificant or discordant effects on the mRNA and protein levels ofα-SMA.CONCLUSION:The tested SMI,especially sorafenib,exert inhibitory effects on activated PSC,which should be further evaluated in preclinical studies. | Anne Elsner Falko Lange Brit Fitzner Martin Heuschkel Bernd Joachim Krause Robert Jaster | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 8 | Variations in Typhoon Landfalls over China显示文摘内部在在中国上的台风 landfalls 的年度可变性用历史、现代的记录被调查。为在中国上在热带气旋活动在北方的主张之上证实并且详细描述到南方变化的目的,在每年的活动的 north-to-south 反关联在历史的气旋记录被证实。当在广东的省上的气旋活动高时(低) ,它趋于低(高度) 在福建的省上。一个类似的空间变化用一个因素分析模型在现代记录被识别,它描出在从在福建,台湾,浙江,上海,江苏,和山东的北省上的活动的广东和海南的南部的省上的台风活动。一乍见陆地代表每年跟随活动的这个模式到的度的台风活动索引被用来识别相关气候变量。在夏天期间在西北的太平洋上包括蒙古和西方的中国和海表面温度(SST ) 之间的海平面的压力差别的一个有用统计回归模型解释中的 26% 个内部年度可变性乍见陆地索引。这被建议一比正常纵贯的压力坡度增加强壮表面在东方在北中国上的风流动;这,在太平洋,上结合了更低的 SST 向南部的中国拿更西的课程的帮助台风。 | Emily A.FOGARTY James B. ELSNER Thomas H. JAGGER Kam-biu LIU Kin-sheun LOUIE | 2006 | Advances in Atmospheric Sciences2006，23，5： | 2 |
| 9 | Synthetic as compared with natural vitamin E is preferentially excreted as α-CEHC in human urine: studies using deuterated α-tocopheryl acetates显示文摘 | Maret G. Traber Angelika Elsner Regina Brigelius-Flohé | 1998 | FEBS Letters1998，，1： | 2 |
| 10 | The hydrometallurgical treatment of zinc silicate ores 显示文摘 | Matthew I G Elsner D | 1977 | Metallurgical Transactions B1977，8，1： | 1 |
| 11 | The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands显示文摘 | Elsner L Muppala V Gehrmann M | 2007 | J Immunol2007，179，8： | 1 |
| 12 | Control of the growth of zinc-iron phases in the hot-dip galvanizing process 显示文摘 | CULCASI J D SER P R ELSNER C I DI SARLI A R | 1999 | Surf Coat Technol1999，122，1： | 1 |
| 13 | Impairment of the hatching process following IVF in the human and improvement of im- plantation by assisting hatching using micromanipulation 显示文摘 | Cohen J Elsner C Kort H | 1990 | HumRepmd1990，5，1： | 1 |
| 14 | Antifungal effect of high- and low-molecular-weight chitosan hydrochloride, carboxymethyl chitosan, chitosan oligosaccharide and N-acetyl-D-glucosamine against Candida albicans, Candida krusei and Candida glabrata显示文摘 | SEYFARTH F SCHLIEMANN S ELSNER P | 2008 | Int J Pharm2008，353，： | 1 |
| 15 | Antifungal effect ofhigh and low-molecular-weight chitosan hydrochloride,carboxy-methyl chitosan,chitosan oligosaccharide and N-acetyl-D-glu-cosamine against Candida albicans,Candida krusei and Candidaglabrata显示文摘 | Seyfarth F Schliemann S Elsner P | 2008 | Int J Pharm2008，353，12： | 1 |
| 16 | Relationship between texture and corrosion resistance in hot-dip galvanized steel sheets显示文摘 | SERE P R CULCASI J D ELSNER C I DI SARLI A R | 1999 | Surface and Coatings Technology1999，122，6： | 1 |
| 17 | Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines显示文摘 | Elsner J Boeekler F Heinemann F W | 2005 | J Med Chem2005，48，： | 1 |
| 18 | Maibach characteristics of the aging skin显示文摘 | Farage MA Miller KW Elsner P | 2013 | Advances in Wound Care2013，2，1： | 1 |
| 19 | Platelet P-select in an dGPIIb/IIIa expression after liver transplantation and resee- tion显示文摘 | Beeker T Jttner B Elsner HA | 2004 | Transpl Int2004，17，： | 1 |
| 20 | Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-betareceptors Ⅰ and Ⅱ 显示文摘 | Guerrero Esteo M Sanchez Elsner T Letamendia A | 2002 | J Biol Chem2002，277，29： | 1 |
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