维普期刊资源整合服务平台（V6.5）

538篇 您的检索式：作者名="Stephan B"

选中清除导出查看参考文献查看引证文献引用追踪共27页首页上一页第1页下一页末页 /27 跳转

	题名	作者	年代	出处	被引量
1	Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘	Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste	2008	Lancet Neurology2008，，5：	4
2	Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype.	C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf	2014	World Journal of Cardiology2014，6，4：	3
3	Loss of the tissue- specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma 显示文摘	Sturm I Stephan C Gillissen B	2006	Cell Death Differ2006，13，4：	1
4	Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective pro-tection of phenolic functions 显示文摘	Mohamed B Stephane L Aziz A	2002	Tetrahedron2002，58，10：	1
5	Response of long rods to moving lateral pressure pulse: numerical evaluation in DYNA3D显示文摘	Sikhanda S Stephan B	2001	International Journal of Impact Engineering2001，26，：	1
6	Biochar amendment techniques for upland rice product in Northern Laos:Soil physical properties,leaf SPAD and grain yield显示文摘	ASAI H SAMSON B K STEPHAN H M	2009	Field crops research2009，111，：	1
7	Nucleic acid-based biomarkers in body fluids of patients with urologic malignancies显示文摘	Ralla B Stephan C Meller S	2014	Crit Rev Clin Lab Sci2014，51，4：	1
8	Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid 显示文摘	KARINE B STEPHAN R	2002	J Pharmacol Exp Ther2002，302，：	1
9	The Oxidation State of Phospholipids Controls the Oxidative Burst in Neutrophil Granulocytes显示文摘	STEPHAN B BERIT R AKOS L	2008	J Immunology2008，181，：	1
10	Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective protection of phenolic functions 显示文摘	Mohamed B Stephane L Aziz A	2002	Tetrahedron2002，58，10：	1
11	Noninvasive coronary artery imaging:magnetic resonance angiography and multidetector computed tomography angiography显示文摘	David A Stephan A Matthew B	2008	Circulation2008，118，5：	1
12	Deletion of M2 gene reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity显示文摘	Ursula J.B Stephane B Quynh N.P		0，，11：	1
13	Injectable tissue-engineered bone repair of a rat calvarial defect显示文摘	Stephan SJ Tholpady SS Gross B		0，，05：	1
14	Prognostic Value of Systemic Endothelial Dysfunction in Patients With Acute Coronary Syndromes: Further Evidence for the Existence of the 'Vulnerable' Patient显示文摘	Stephan F Susanne B Andreas M	2004	Circulation2004，110，：	1
15	High-flow nasal oxygen vs noninvasive positive airway pressure in hypox- emic patients after cardiothoracic surgery: a randomized clinical Trial显示文摘	Stephan F Barrucand B Petit P	2015	JAMA2015，313，23：	1
16	显示文摘	Stephane C Thomas R Martine L B	2007	IEEE Trans Comp and Pack Tech2007，30，：	1
17	Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: Interaction with the transporters on Caco-2 cells显示文摘	Stephan AM Ulrich FS Stefan B	2008	Int J Pharm2008，362，12：	1
18	Interleukin 6 activates heat shock protein 90B gene expression 显示文摘	Stephanou A Amin B Isenberg DA	1997	Biochem J1997，，：	1
19	Investigation of the mechanismof chlorination of glyphosate and glycine in water显示文摘	AKBAR M MARIAN B STEPHAN B	2006	Water Research2006，40，：	1
20	Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘	Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch Eckhart Dühmke Hans-Konrad Müller-Hermelink? Klaus Wilms§	2000	Gastroenterology2000，，5：	1

返回顶部每页显示：

共27页首页上一页第1页下一页末页 /27 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示