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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Comparative efficacy of once daily, 5-day short-course therapy with clarithromycin extended-release versus twice daily, 7-day therapy with clarithromycin immediate-release in acute bacterial exacerbation of chronic bronchitis显示文摘 | Gotfried M Notario G Spiller J | 2005 | Curr Med Res Opin2005，21，2： | 1 |
| 3 | Production of yellow color inflowers: redirection of flavonoid biosynthesis in Petunia 显示文摘 | Davis K M Bloor S J Spiller G B | 1998 | Plant J1998，，13： | 1 |
| 4 | Localized defects in multilayers coatings显示文摘 | Stearns D G Mirkarimi P B Spiller E | 2004 | Thin Solid Film2004，446，： | 1 |
| 5 | Role of water-soluble dietary fiber in the management of elevated plasma cholesterol in healthy subjects 显示文摘 | Haskell W L Spiller G A Jensen C D | 1992 | The American Journal of Cardiology1992，69，5： | 1 |
| 6 | Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system显示文摘 | John M Hebden Clive G Wilson Robin C Spiller | 1999 | Pharm Res1999，16，7： | 1 |
| 7 | Production of yellow color in flowers: redirection of falconoid biosynthesis in Petunia 显示文摘 | Davies K M Bloor S J Spiller G B | 1998 | Plant Journal1998，13，2： | 1 |
| 8 | Irritable bowel syndrome,inflammatory bowel disease and the microbiome显示文摘 | Major G Spiller R | 2013 | Curr Opin Endocrinol Diabetes Obes2013，，27： | 1 |
| 9 | Nucleation and growth of thin films显示文摘 | Venables J Spiller G Hanbucken M | 1984 | Rep Prog Phys1984，47，： | 1 |
| 10 | Electronic Shopping: The Effect of Customer Interfaces on Traffic and Sales 显示文摘 | Lohse G L Spiller P | 1998 | Communica- tions of the ACM1998，419，7： | 1 |
| 11 | Coxsackie B viruses that use human DAF as a receptor infect pig cells via pig CAR and do not use pig DAF 显示文摘 | Spiller OB Goodfellow G David J | 2002 | J Gen Vir2002，83，1： | 1 |
| 12 | How to sustain the customer experience:an overview of experience Components that co-create value with the customer显示文摘 | Gentile C Spiller N Noci G | | 0，，： | 1 |
| 13 | 查看详情显示文摘 | Losi P Briganti E Magera A Spiller D Ristori C Battolla B Balderi M Kull S Balbarini A Stefano R D Soldani G | | 0，，： | 1 |
| 14 | A case of vinblastine overdose managed with plasma exchange显示文摘 | Spiller M Marson P Perilongo G | 2005 | Pediatr Blood Cancer2005，45，3： | 1 |
| 15 | Safety of an astaxanthin-rich haematococcus pluvialis algal extract: a randomized clinical trial显示文摘 | Spiller G A Dewell A | 2003 | J Med Food2003，6，1： | 1 |
| 16 | InternetRetail Store De- sign: How the User Interface Influences Traffic and Sales显示文摘 | LOHSE G L SPILLER P | 1999 | Journal of Computer-Mediated Communi- cation1999，5，2： | 1 |
| 17 | Time-dependent melting and superheating of lead crystallites显示文摘 | | 1982 | Philos Mag A1982，46，： | 1 |
| 18 | Health effect of mediterranean diets and monounsaturated facts显示文摘 | Spiller G A | 1991 | Cereal Foods World1991，36，9： | 1 |
| 19 | Multi-parameter analysis of the kinetics of NF-κB signalling and transcription in single living cells显示文摘 | Nelson G Paraoan L Spiller DG | 2002 | Cell Sci2002，115，6： | 1 |
| 20 | How to Sustain the Customer Experi- ence: An Overview of Experience Components that Co-create Value With the Customer显示文摘 | Gentile C Spiller N Noci G | 2007 | European Management Journal2007，25，5： | 1 |
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