|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | A second conserved GAF domain cysteine is required for the blue/green photoreversibility of cy- anobacteriochrome TIr0924 from Thermosynecho- coccus elongates 显示文摘 | Rockwell N C Njuguna S L Roberts L Castillo E Parson V L Dwojak S Lagarias J C Spiller S C | 2008 | Biochemistry2008，47，： | 1 |
| 3 | Irritable bowel syndrome: a little understood organic bowel disease? 显示文摘 | Talley N J Spiller R | 2010 | Lancet2010，360，9332： | 1 |
| 4 | Fare determination in airline hub-and-spoke networks显示文摘 | Brueckner Jan K N J Dyer P T Spiller | 1992 | Rand Journal of Economics1992，23，： | 1 |
| 5 | Irritable bowel syndrome: a little understood organic bowel disease? 显示文摘 | Talley N J Spiller R | 2010 | Lancet2010，360，9332： | 1 |
| 6 | A, et aL Inhihitinn of nuclearfactor kappa-B signaling reduces growth in m<*dullul)last?ma in ww显示文摘 | Spiller S h’ IxtgKflon N J Deckanl I | 2011 | BMC Cancer2011，，11： | 1 |
| 7 | The preferential dopamine D3 receptor antagonist S33138 inhibits co-caine reward and cocaine-triggered relapse to drug-seeking behaviorin rats显示文摘 | Peng XQ Ashby CR Jr Spiller K Li X Li J Thomasson N | 2009 | Neuropharmacology2009，56，4： | 1 |
| 8 | How to sustain the customer experience:an overview of experience Components that co-create value with the customer显示文摘 | Gentile C Spiller N Noci G | | 0，，： | 1 |
| 9 | Irritable bowel syndrome: a little understood organic bowel disease显示文摘 | Talley N J Spiller R | 2002 | Lancet2002，360，： | 1 |
| 10 | How to Sustain the Customer Experi- ence: An Overview of Experience Components that Co-create Value With the Customer显示文摘 | Gentile C Spiller N Noci G | 2007 | European Management Journal2007，25，5： | 1 |
| 11 | Effect of a diet high in monounsaturated fat from almonds on plasma cholesterol and lipoproteins 显示文摘 | Spiller G A Jenkins D J Cragen L N | 1992 | J Am Coll Nutr1992，11，2： | 1 |
| 12 | Irritable bowel syndrome: a little un- derstood organic bowel disease 显示文摘 | Talley N J Spiller R | 2002 | Lancet2002，360，： | 1 |
| 13 | Inhibition of nuclear factor kappa-B signaling reduces growth in medul- loblastoma in vivo显示文摘 | SPILLER SE LOGSDON N J DECKARD LA | 2011 | BMC cancer2011，11，1： | 1 |
| 14 | Working memory capacity and retrieval from long-term memory: the role of controlled search显示文摘 | Unswortb N Brewer GA Spillers GJ | 2013 | Mem Cognit2013，41，2： | 1 |
| 15 | Working memory capacity and retrieval limitations from long-term memory: an examination of differences in accessibility显示文摘 | Unsworth N Spillers GJ Brewer GA | 2012 | Q J Exp Psychol2012，65，12： | 1 |
| 16 | Actor-network theory and stakeholder collaboration: The case of cultural districts 显示文摘 | Arnaboldi M Spiller N | 2011 | Tourism Management2011，32，3： | 1 |
| 17 | Calcium-dependent regulation of the cell cycle via a novel MAPK- NF-kappaB pathway in Swiss 3 3'3 cells 显示文摘 | See V Rajala N K Spiller D G | 2004 | J Cell Biol2004，166，5： | 1 |
| 18 | Calcium-dependent regulation of the cell cycle via a novel MAPK-NF-kappaB pathway in Swiss 3T3 cells显示文摘 | SEE V RAJALA N K SPILLER D G | 2004 | J Cell Biol2004，166，5： | 1 |
| 19 | How to Sustain the Customer Experience:An Overview of Experience Components that Co- create Value with the Customer显示文摘 | GENTILE C SPILLER N NOCI G | 2007 | European Management Journal2007，25，5： | 1 |
| 20 | Stylet activities and potato virus Y vector efficiencies by the aphids Brachycaudus helichrysi and Drepanosiphum pla- tanoidis 显示文摘 | POWELL G HARRINGTON R SPILLER N J | 1992 | Entomol Exp App1992，62，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员