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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Sex determination in mammalian germ cells显示文摘细菌细胞是精子和卵母细胞的先锋并且因此为种的幸存是批评的。在哺乳动物,他们在胎儿的生活期间被指定,移居到发展中的性腺然后经历他们在期间被指示的一个批评时期,到,由身体采用适当性命运。在一个胎儿的卵巢,细菌房间进入成熟分裂并且,在一个胎儿的睾丸承诺卵子发生,他们避免入口进成熟分裂并且相反经历有丝分裂的拘捕并且向精子发生成熟。这里,我们讨论我们到目前为止对细菌房间的性特定的区别的规定知道的,就体的房间,以及在细菌房间以内的批评内在的变化生产的外来的分子的暗示而言。这评论几乎专门集中于我们这些事件的理解在老鼠模型。 | Cassy M Spiller Josephine Bowles | 2015 | Asian Journal of Andrology2015，17，3： | 2 |
| 3 | Political institutions and electric utility investment:A cross-nation analysis 显示文摘 | BERGARA M E HENISZ W J SPILLER P T | 1998 | California Management Review1998，40，2： | 1 |
| 4 | Environmental relevance of heavy metal substituted chlorophylls using the example of water plants显示文摘 | Kupper H Kupper F Spiller M | 1996 | J Exp Bot1996，47，： | 1 |
| 5 | Environmental relevance of heavy metal-substituted chlorophylls using the example of water plants显示文摘 | Kupper H Kupper F Spiller M | 1996 | Exp Bot1996，47，： | 1 |
| 6 | Towards a unified genetie map for diploid roses显示文摘 | Spiller M Linde M Oyant L H S | 2011 | Theor Appl Genet2011，122，： | 1 |
| 7 | Membrane complement regulators protect against the development of type Ⅱ collagen induced arthritis in rats显示文摘 | Mizuno M Nishikawa K Spiller OB | 2001 | Arthritis Rheum2001，44，10： | 1 |
| 8 | Effects of iron and oxygen on chlorophyll biosynthesis in vivo observations on iron and oxygen-defieient plants 显示文摘 | Spiller S C Castelfranco A M Castelfranco P A | 1982 | Plant Physiol1982，69，1： | 1 |
| 9 | Environmental Rel evanee of Heavy Metal-Substituted Chlorophylls U sing the Example of Water Plants显示文摘 | Kupper H Kupper F Spiller M | 1996 | Journal of Ex perimental Botany1996，47，： | 1 |
| 10 | Comparative efficacy of once daily, 5-day short-course therapy with clarithromycin extended-release versus twice daily, 7-day therapy with clarithromycin immediate-release in acute bacterial exacerbation of chronic bronchitis显示文摘 | Gotfried M Notario G Spiller J | 2005 | Curr Med Res Opin2005，21，2： | 1 |
| 11 | Production of yellow color inflowers: redirection of flavonoid biosynthesis in Petunia 显示文摘 | Davis K M Bloor S J Spiller G B | 1998 | Plant J1998，，13： | 1 |
| 12 | Environmental relevance of heavy metal-substituted chlorophylls using the example of water plants显示文摘 | KUPPER H KIIPPER F SPILLER M | 1996 | Journal of Experimental Botany1996，47，295： | 1 |
| 13 | Intestinal barrier function in health and gastrointestinal disease显示文摘 | Camilleri M Madsen K Spiller R | 2012 | Neurogastro- enterolMotil2012，24，6： | 1 |
| 14 | Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system显示文摘 | John M Hebden Clive G Wilson Robin C Spiller | 1999 | Pharm Res1999，16，7： | 1 |
| 15 | Effect of ab;orbable topical Hemostatic agents on the relaxation time of blood:an in vitro study with implications for postoperativ emagnetic resonance imaging显示文摘 | Spiller M Tenner MS Couldwell WT | 2001 | J Neurosurg2001，95，4： | 1 |
| 16 | The my-ostatin gene is a downstream target gene of basic helix-loop-helixtranscription factor MyoD 显示文摘 | SPILLER M P KAMBADUR R JEANPLONG F | 2002 | Molecular and Cellular Biology2002，22，20： | 1 |
| 17 | Production of yellow color in flowers: redirection of falconoid biosynthesis in Petunia 显示文摘 | Davies K M Bloor S J Spiller G B | 1998 | Plant Journal1998，13，2： | 1 |
| 18 | Intestinal barrier function in health and gastrointestinal disease 显示文摘 | Camilleri M Madsen K Spiller R | 2012 | Neurogastroenterol Motil2012，24，6： | 1 |
| 19 | Nucleation and growth of thin films显示文摘 | Venables J Spiller G Hanbucken M | 1984 | Rep Prog Phys1984，47，： | 1 |
| 20 | The myosta- tin gene is a downstream target gene of basie helix-loop- helix transcription factor MyoD 显示文摘 | Spiller M P Kambadur R leanplong F | 2002 | Molecular and Cellu- lar Biology2002，22，20： | 1 |
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