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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer显示文摘 | Konstantinopoulos PA Spentzos D Karlan BY | 2010 | J Clin Oncol2010，28，22： | 1 |
| 3 | Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy显示文摘 | Out HH Can H Spentzos D | 2007 | Diabetes Care2007，30，3： | 1 |
| 4 | Formative evaluation of a prototype system for automated analysis of mass spectrometry data显示文摘 | Li M Spentzos D | 2005 | AMIA Annu Symp Proc2005，，： | 1 |
| 5 | Keapl mutations and Nrf2 pathway activation in epithelial ovarian cancer 显示文摘 | KONSTANTINOPOULOS PA SPENTZOS D FOUNTZILAS E | 2011 | Cancer Res2011，71，15： | 1 |
| 6 | Prediction of diabetic nephropathy using urine proteomic profiling 10 years pri- or to development of nephropathy 显示文摘 | Otu HH Can H Spentzos D | 2007 | Diabetes Care2007，30，3： | 1 |
| 7 | Keapl mutations and Nrf2 pathway activation in epithelial? ovarian cancer显示文摘 | Konstantinopoulos PA Spentzos D Fountzilas E | 2011 | Cancer Res2011，71，15： | 1 |
| 8 | IGF ax- is gene expression patterns are prognostic of survival in epi- thelial ovarian cancer 显示文摘 | SPENTZOS D CANNISTRA SA GRALL FA | 2007 | Endocr Relat Cancer2007，14，3： | 1 |
| 9 | Keapl mutations and Nrf2 pathway activation in epithelial ovarian cancer显示文摘 | Konstantinopoulos PA Spentzos D Fountzilas E | 2011 | Cancer Res2011，71，15： | 1 |
| 10 | Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy 显示文摘 | Out HH Can H Spentzos D | 2007 | Diabetes Care2007，30，： | 1 |
| 11 | Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome显示文摘 | Wolf C. Prall Akos Czibere Franck Grall Dimitrios Spentzos Ulrich Steidl Aristoteles Achilles Nikolaus Giagounidis Andrea Kuendgen Hasan Otu Astrid Rong Towia A. Libermann Ulrich Germing Norbert Gattermann Rainer Haas Manuel Aivado | 2009 | International Journal of Hematology2009，，2： | 1 |
| 12 | Gene signatures of progression and metastasis in renal cell cancer 显示文摘 | Jones J Otu H Spentzos D | 2005 | Clin Cancer Res2005，11，16： | 1 |
| 13 | Gene - expression profiling in epithelial ovarian cancer显示文摘 | Konstantinopoulos PA Spentzos D Cannistra SA | 2008 | Nature Clinical Practice Oncology2008，5，10： | 1 |
| 14 | Computational fluid dynamic study of three-dimensional dynamic stall of various platform shapes显示文摘 | Spentzos A Barakos G N Badcock K J Richards B E Coton F N Galbraith R A McD | 2007 | Journal of Aircraft2007，44，4： | 1 |
| 15 | Prediction of diabeticnephropathy using urine proteomic profiling 10 years prior todevelopment of nephropathy显示文摘 | Otu HH Can H Spentzos D | 2007 | Diabetes Care2007，30，3： | 1 |
| 16 | IGF axis gene expression patterns are prognostic of survival in epithe- lialovarian cancer 显示文摘 | Spentzos D Cannistra SA Grall F | 2007 | Endocr Relat Eancer2007，14，3： | 1 |
| 17 | Gene signatures of progression and metastasis in renal cell cancer显示文摘 | Jones J Otu H Spentzos D Kolia S Inan M Beecken W D | 2005 | Clin Cancer Res2005，11，： | 1 |
| 18 | Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy 显示文摘 | Otu HH Can H Spentzos D | 2007 | Diabetes Care2007，30，3： | 1 |
| 19 | Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy显示文摘 | Otu HH Can H Spentzos D | 2007 | Diabetes Care2007，30，3： | 1 |
| 20 | Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy显示文摘 | Otu HH Can H Spentzos D | 2007 | Diabetes Care2007，30，3： | 1 |
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