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| 1 | Mitochondrial metabolism and cancer显示文摘Glycolysis 长在癌症房间为精力生产和 anabolism 的生长被看作了主要新陈代谢的过程。尽管如此的一个看法为仍然在诊所被使用的强大的成像工具的发展是有帮助的,线粒体在 oncogenesis 起一个关键作用,现在是清楚的。除施加中央 bioenergetic 函数以外,线粒体确实为肿瘤同化提供积木,控制氧化还原作用和钙动态平衡,参予 transcriptional 规定,并且管理房间死亡。因此,线粒体为新奇 anticancer 代理人的发展组成有希望的目标。然而,肿瘤产生,进行,并且回答功能依靠未经触动的 mitochondrial 新陈代谢到在有主人免疫系统,和许多免疫学的亲密串音的上下文的治疗。这里,我们考察房间内在的癌症和线粒体影响都 oncogenesis 通过走的房间外来的机制,与指向为癌症治疗的 mitochondrial 新陈代谢的治疗学的潜力的一个焦点。 | Paolo Ettore Porporato Nicoletta Filigheddu José Manuel Bravo-San Pedro, Guido Kroemer, Lorenzo Galluzzi José Manuel Bravo-San Pedro, Guido Kroemer José Manuel Bravo-San Pedro, Guido Kroemer José Manuel Bravo-San Pedro, Guido Kroemer José Manuel Bravo-San Pedro, Guido Kroemer Guido Kroemer Guido Kroemer Lorenzo Galluzzi Lorenzo Galluzzi | 2018 | Cell Research2018，28，3： | 33 |
| 2 | MLKL regulates necrotic plasma membrane permeabilization显示文摘 | Lorenzo Galluzzi | 2014 | Cell Research2014，24，2： | 12 |
| 3 | Calreticulin and cancer显示文摘Calreticulin(CALR)is an endoplasmic reticulum(ER)-resident protein involved in a spectrum of cellular processes.In healthy cells,CALR operates as a chaperone and Ca^(2+)buffer to assist correct protein folding within the ER.Besides favoring the maintenance of cellular proteostasis,these cell-iintrinsic CALR functions support Ca^(2+)-dependent processes,such as adhesion and integrin signaling,and ensure normal antigen presentation on MHC Class I molecules.Moreover,cancer cells succumbing to immunogenic cell death(ICD)expose CALR on their surface,which promotes the uptake of cell corpses by professional phagocytes and ultimately supports the initiation of anticancer immunity.Thus,loss-of-function CALR mutations promote oncogenesis not only as they impair cellular homeostasis in healthy cells,but also as they compromise natural and therapy-driven immunosurveillanee.However,the prognostic impact of total or membrane-exposed CALR levels appears to vary considerably with cancer type.For instance,while genetic CALR defects promote pre-neoplastic myeloproliferation,patients with myeloproliferative neoplasms bearing CALR mutations often experience improved overall survival as compared to patients bearing wild-type CALR.Here,we discuss the context-dependent impact of CALR on malignant transformation,tumor progression and response to cancer therapy. | Jitka Fucikova Radek Spisek Guido Kroemerc Lorenzo Galluzzi | 2021 | Cell Research2021，31，1： | 12 |
| 4 | Mechanisms of p53-mediated mitochondrial membrane permeabilization显示文摘 | Eugenia Morselli | 2008 | Cell Research2008，18，7： | 3 |
| 5 | Editing the Shape Morphing of Monocomponent Natural Polysaccharide Hydrogel Films显示文摘Shape-morphing hydrogels can be widely used to develop artificial muscles,reconfigurable biodevices,and soft robotics.However,conventional approaches for developing shape-morphing hydrogels highly rely on composite materials or complex manufacturing techniques,which limit their practical applications.Herein,we develop an unprecedented strategy to edit the shape morphing of monocomponent natural polysaccharide hydrogel films via integrating gradient cross-linking density and geometry effect.Owing to the synergistic effect,the shape morphing of chitosan(CS)hydrogel films with gradient cross-linking density can be facilely edited by changing their geometries(length-to-width ratios or thicknesses).Therefore,helix,short-side rolling,and longside rolling can be easily customized.Furthermore,various complex artificial 3D deformations such as artificial claw,horn,and flower can also be obtained by combining various flat CS hydrogel films with different geometries into one system,which can further demonstrate various shape transformations as triggered by pH.This work offers a simple strategy to construct a monocomponent hydrogel with geometry-directing programmable deformations,which provides universal insights into the design of shape-morphing polymers and will promote their applications in biodevices and soft robotics. | Hao Hu Chao Huang Massimiliano Galluzzi Qiang Ye Rui Xiao Xuefeng Yu Xuemin Du | 2021 | Research2021，，1： | 3 |
| 6 | Immunogenic Cell Death in Cancer Therapy显示文摘 | Guido Kroemer Lorenzo Galluzzi Oliver Kepp Laurence Zitvogel | 2013 | Annual Review of Immunology2013，，： | 2 |
| 7 | Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance显示文摘 | Laurence Zitvogel Lorenzo Galluzzi Mark J. Smyth Guido Kroemer | 2013 | Immunity2013，，1： | 2 |
| 8 | FADD: an endogenous inhibitor of RIP3-driven regulated necrosis显示文摘 | Lorenzo Galluzzi Oliver Kepp Guido Kroemei | 2011 | Cell Research2011，21，10： | 2 |
| 9 | Distinctive clinical features of mild cognitive impairment with subcortical cerebrovascular disease 显示文摘 | Galluzzi S Sheu CF Zanetti O | 2005 | Dement Geriatr Cogn2005，19，： | 1 |
| 10 | Management Strategies for Herpes Zoster and Postherpetic Neuralgia显示文摘 | Galluzzi DO | 2007 | J Am Osteopath Assoc2007，1073，： | 1 |
| 11 | Necroptosis:a specialized pathway of programmed necrosis 显示文摘 | Galluzzi L Kroemer G | 2008 | Cell2008，135，7： | 1 |
| 12 | Necroptosis :A specialized pathway of programmed necrosis显示文摘 | Galluzzi L Kroemer G | 2008 | Cell2008，135，7： | 1 |
| 13 | Regulation of autophagy by cytoplasmic p53 显示文摘 | Tasdemir E Maiuri MC Galluzzi L | 2008 | Nat Cell Biol2008，10，6： | 1 |
| 14 | Classification of cell death : recommendations of the Nomenclature Committee on Cell Death 2009 显示文摘 | Kroemer G Galluzzi L Vandenabeele P | 2009 | Cell Death Differ2009，16，1： | 1 |
| 15 | Mild cognitive impairment with subcortical vascular features : clinical characteristics and outcome显示文摘 | Frisoni GB Galluzzi S Bresciani L | 2002 | J Neurol2002，249，10： | 1 |
| 16 | Topical therapies in the management pain显示文摘 | Stanos 8P Galluzzi KE | 2015 | Postgrad Meal2015，125，41： | 1 |
| 17 | Mitochondrial membrane permeabilization in cell death 显示文摘 | Kroemer G Galluzzi L Brenner C | 2007 | Physiol Rev2007，87，1： | 1 |
| 18 | Caspase-3 and prostaglandinssignal for tumor regrowth in cancer therapy显示文摘 | Galluzzi L Kepp O Kroemer G | 2012 | Oncogene2012，31，23： | 1 |
| 19 | Targeting mitochondria for cancer therapy 显示文摘 | Fulda S Galluzzi L Kroemer G | 2010 | Nat Rev Drug Discov2010，9，6： | 1 |
| 20 | Hippocampal and amyg- dalar volume changes in elderly patients with Alzheimer's disease and schizophrenia显示文摘 | Prestia A Boccardi M Galluzzi S | 2011 | Psychiatry Res2011，192，： | 1 |
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