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1Clinical importance of aspirin and clopidogrel resistance显示文摘Aspirin and clopidogrel are important components of medical therapy for patients with acute coronary syndromes, for those who received coronary artery stents and in the secondary prevention of ischaemic stroke. Despite their use, a significant number of patients experience recurrent adverse ischaemic events. Interindividual variability of platelet aggregation in response to these antiplatelet agents may be an explanation for some of these recurrent events, and small trials have linked 'aspirin and/or clopidogrel resistance', as measured by platelet function tests, to adverse events. We systematically reviewed all available evidence on the prevalence of aspirin/clopidogrel resistance, their possible risk factors and their association with clinical outcomes. We also identified articles showing possible treatments. After analyzing the data on different laboratory methods, we found that aspirin/clopidogrel resistance seems to be associated with poor clinical outcomes and there is currently no standardized or widely accepted definition of clopidogrel resistance. Therefore, we conclude that specific treatment recommendations are not established for patients who exhibit high platelet reactivity during aspirin/clopidogrel therapy or who have poor platelet inhibition by clopidogrel.Gergely Feher Andrea Feher Gabriella Pusch Katalin Koltai Antal Tibold Beata Gasztonyi Elod Papp Laszlo Szapary Gabor Kesmarky Kalman Toth 2010World Journal of Cardiology2010,2,7:36
2抗血小板聚集药物的机制研究进展显示文摘通过文献综述,发现抗血小板聚集药物在心血管疾病中有良好应用,但其出血不良反应仍存在,一些新药机制不明确。因此,抗血小板聚集的机制研究还需加快。一种新型的抗血小板聚集药物终将诞生,如EP3受体抑制剂,为新抗血小板聚集药物的研究提供思路。王晓锋 陈乃宏 王文 2010中国康复理论与实践2010,16,10:11
3解读PRoFESS研究对缺血性卒中抗血小板治疗实践的影响显示文摘备受关注的卒中二级预防有效性试验(PRoFESS,Prevention Regimen for Effectively Avoiding Second Strokes)研究近期在《新英格兰杂志》上正式发表[1],该研究被视为迄今最大规模的卒中二级预防研究,来自35个国家和地区的695个中心参与了该研究,共收集20332例患者,其中亚洲人群占36%,中国贡献了18%的研究病例。王伊龙 王春雪 赵性泉 王拥军 2008中国卒中杂志2008,3,12:6
4浅谈药理学教学中抗血小板药物的知识拓展显示文摘抗血小板药物在心血管疾病中有广泛的应用,但其仍存在出血不良反应,这是由于一些新药机制不明确所造成的。因此,抗血小板药物的机制研究还需加快。新型的抗血小板药物终将诞生,如前列腺素EP3受体抑制剂,为新抗血小板聚集药物的研究提供思路。白莉 宋宇 吴宿慧 2014中国西部科技2014,13,1:0
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