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| 1 | Identification of quantitative trait loci associated with salt tolerance at seedling stage from Oryza rufipogon显示文摘土壤咸度是影响工厂生长和庄稼生产的主要不能生活的压力之一。在现在的学习,在米饭幼苗舞台的盐忍耐用 87 根基因渗入线(IL ) 被评估,它从在精英 indica 栽培变种 Teqing 和普通野米饭(Oryza rufipogon Griff ) 的就职之间的一个十字被导出。实质的变化为包括盐忍耐 20 的四个特点(圣) 被观察,相对的根干燥重量(RRW ) ,干燥重量(RSW ) 和相对总数弄干的相对射击重量(RTW ) 。圣断然显著地所有另外的三个特点地被相关。与这四个特点联系的 15 通常认为的量的特点 loci (QTL ) 的一个总数用单个点的分析被检测,它位于染色体 1, 2, 3, 6, 7, 9 和 10 与解释 phenotypic 变化的 8%26% 。O。在 13 QTL (86.7%) 的导出 rufipogon 的等位基因能在 Teqing 背景改进盐忍耐。影响 RRW, RSW 和 RTW 的四 QTL 簇在染色体上被发现 6, 7, 9 和 10 分别地。在这四 QTL 簇之中,包括三 QTL (qRRW10, qRSW10 和 qRTW10 ) 的主要的簇在染色体 10 的长手臂上在制造者 RM271 附近被发现,并且 O。分别地,当 phenotypic 变化由这解释为三个特点的三单个 QTL 从 19% ~ 26% 变化了时,在这三 loci 的导出 rufipogon 的等位基因与 22.7% , 17.3% 和 18.5% 的添加剂效果增加了 RRW, RSW 和 RTW。另外,几腌容忍的 IL 被选择并且能被用于识别并且利用有利的盐从普通野米饭的容忍的基因并且在盐使用容忍的米饭繁殖编程序。 | Lei Tian,Lubin Tan,Fengxia Liu,Hongwei Cai,Chuanqing Sun State Key Laboratory of Plant Physiology and Biochemistry,National Centre for Evaluation of Agricultural Wild Plant(Rice), Laboratory of Crop Heterosis and Utilization of Ministry of Education Beijing Key Laboratory of Crop Genetic Improvement and Genome of Ministry of Agriculture,Department of Plant Genetics and Breeding,China Agricultural University,Beijing 100193,China | 2011 | Journal of Genetics and Genomics2011，38，12： | 26 |
| 2 | Isolation and Purification of Isoaloeresin D and Aloin from Aloe vera by High-speed Counter-current Chromatography显示文摘Objective To develop an efficient method to isolate and purify the main components isoaloeresin D and aloin from Aloe vera for its industrial production.Methods High-speed counter-current chromatography was used to isolate isoaloeresin D and aloin in a one-step separation from dried crude extract of A.vera.The biphasic solvent system composed of hexane-ethyl acetate-acetone-water(0.2:5:1.5:5) was used at a flow rate of 1.0 mL/min,while the lipophilic phase was selected as the mobile phase and the apparatus was rotated at 840 r/min.The effluent was detected at 254 nm.Results Isoaloeresin D(53.1 mg) and aloin(106.9 mg) were separated from the crude extract(384.7 mg) with the purities of 98.6% and 99.5%,respectively.Conclusion HSCCC is a powerful technique for isolation and separation of chemical composition from aloe. | WAN Jin-zhi1,CHEN Xin-xia1,QIU Chun-mei1,LIN Xiang-cheng2 1.Laboratory for Pharmaceutical Analysis and Quality Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China 2.Institute of Fine Chemicals and Synthetic Drugs,Sun Yat-sen University,Guangzhou 510006,China | 2010 | Chinese Herbal Medicines2010，2，2： | 12 |
| 3 | FOXP3 expression and clinical characteristics of hepatocellular carcinoma显示文摘AIM: To study the biological and clinical characteristics of transcription factor forkhead box protein 3 (FOXP3) in hepatocellular carcinoma (HCC). METHODS: We analyzed the expression and localization of FOXP3 in HCC tissues and cell lines to evaluate its biological features. The relationship between FOXP3 staining and clinical risk factors of HCC was assessedto identify the clinical characteristics of FOXP3 in HCC. RESULTS: The mRNA and protein expression of FOXP3 were found in some hepatoma cell lines. Immunohistochemical (IHC) analysis of HCC sections revealed that 48% of HCC displayed FOXP3 staining, but we did not find any FOXP3 staining in normal liver tissues and para-tumor tissues. IHC and Confocal analysis showed that the expressions of FOXP3 were mainly present in the nucleus and cytoplasm of tumor cells in tissues or cell lines. In HCC, the distribution of FOXP3 was similar to that of the cirrhosis, but not to the hepatitis B virus. Those findings implicate that FOXP3 staining seems to be associated with the high risk of HCC. CONCLUSION: The clinical characteristics of FOXP3 in HCC warrants further studies to explore its functions and roles in the cirrhosis and development of HCC. | Wei-Hua Wang, Jun-Zhi Wang, National Center for Safety Evaluation of Drugs, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China Wei-Hua Wang, Chang-Li Jiang, Cun Zhang, Bo Yan, Wei Zhang, Wei Han, Ying-Qi Zhang, Biotechnology Center, School of Pharmacy, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Wei-Hua Wang, Chang-Li Jiang, Cun Zhang, Bo Yan, Wei Zhang, Wei Han, Ying-Qi Zhang, State Key Laboratory of Cancer Biology, Xi’an 710032, Shaanxi Province, China Wei Yan, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Yu-Hai Zhang, Department of Health Statistics, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Jiang-Tao Yang, Department of Pathology, Xi’an Gaoxin Hospital, Xi’an 710032, Shaanxi Province, China | 2010 | World Journal of Gastroenterology2010，16，43： | 10 |
| 4 | Discussion on the Index System of Intensive Land Use Evaluation in Development Area显示文摘The establishment of evaluation index system is the key to the evaluation of intensive land use.On the basis of expounding connotation,characteristics and the principle of establishing evaluation index system,and as for the problems existing in Evaluation Regulation(Trial)of Intensive Land Use in Development Area,regarding the evaluation index system of intensive land use in the development area,in the light of the connotation of intensive land use in development area,coupled with the practical situation of the land use in China's development area,after referring to the research achievements of domestic and abroad scholars,some suggestions are put forward in order to improve and perfect the evaluation index system of intensive land us in development area. | LIU Xiang-dong1,GAO Jie2 1.School of Land Science and Technology,China University of Geosciences,Beijing 100083,China 2.Weida Real Estate Evaluation Corporation of Henan Province,Luoyang 471000,China | 2011 | Asian Agricultural Research2011，3，2： | 7 |
| 5 | Corrosion behavior of Mg-Y alloy in NaCl aqueous solution | Xin Zhang a,b,c,Kui Zhang a,Xia Deng a,Hongwei Li b,c,Yongjun Li a,Minglong Ma a,Ning Li b,c,Yanlong Wang b,c a State Key Laboratory for Fabrication and Processing of Nonferrous Metals,Beijing General Research Institute for Nonferrous Metals,Beijing 100088,China b Beijing Engineering Research Center for Advanced Manufacturing and Evaluation of Special Vehicle Parts,Beijing 100072,China c Center of Technology,Beijing North Vehicle Group Corporation,Beijing 100072,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 7 |
| 6 | 阿片成瘾者中的人格障碍问题显示文摘本文采用多种人格障碍筛查表对接受戒毒治疗的80例阿片成瘾者进行了测查。结果显示,各种人格障碍(personalitydisorders,PDs)的现患率为86%,其中戏剧性PD、依赖性PD、回避性PD和边缘性PD各分别占44%、36%、35%和76%。具有统计学意义的多种PD为:(1)依赖性-回避性(OR值=13.9;95%可信限范围=4.55,42.83);(2)戏剧性-依赖性(OR值=2.8;95%可信限范围=1.11,7.26);(3)边缘性-戏剧性(OR值=5.5;95%可信限范围=1.45,20.87);(4)边缘性-依赖性(OR值=3.9;95%可信限范围=1.04,15.04)。此结果提示,在阿片成瘾者中存在着各种严重的人格障碍。 | Adenekan Oyefeso, Hamid Ghodse, Carmel Clancy, Vanessa Crawford, Stephen Byrne(Research Evaluation and Monitoring Unit Department of Psychiatry of Addictive Behaviour St George’s Hospital Medical School London SW17 ORE) | 1998 | 中国药物依赖性杂志1998，7，2： | 6 |
| 7 | 儿科人群药物临床试验技术指导原则(征求意见稿)显示文摘临床上儿科超说明书用药极为普遍,如何使儿童安全、有效用药是药物研发领域的热点,但是规范与推动儿科药物临床试验是一项全球性的难题。儿科人群的生理机能与成人相比具有其特殊性,因此,儿科人群药物临床试验相比于成人临床试验面临更全面和更完善的方案设计和可操作要求。近些年来,美国和欧盟已陆续颁布了针对儿科人群药物临床试验的指导性建议,加强对其试验过程的规范力度;但是在我国,目前颁布的与药物临床试验相关的法律法规或指南要求中,尚并未专门针对儿科人群药物临床试验提出具体的指导建议。2015年8月4日,国家食品药品监督管理总局药品审评中心发布了《儿科人群药物临床试验技术指导原则》征求意见稿。这是我国药品监管部门首次专门针对儿科人群药物临床试验提出的指导性建议。该指导原则制订的目的是进一步规范我国儿科人群药物临床试验设计,提高试验质量,使试验数据能充分地支持儿科药物上市,同时避免不必要的重复试验。该指导原则为国内儿科药物研发企业及儿科药物临床试验机构提供了可参考的临床试验基本原则和操作指南。 | Center for Drug Evaluation,China Food and Drug Administration | 2015 | 中国临床药理学杂志2015，31，16： | 5 |
| 8 | 中国发展指数(2008)编制成果研究显示文摘'中国人民大学中国发展指数(2008)'对我国省级行政区社会经济综合发展的均衡性进行了分析。报告得出的初步结论是:我国的综合发展仍然保持较明显的区域效应,呈现板块式结构的特征。但是,区域发展的板块格局稳中有变,相对落后地区板块中包含的省区数目有所减少;绝大多数省区稳定持续增长,中西部地区发展开始增速;相当多的省区在注重经济发展的同时,已开始注重社会环境发展,大多数省区越来越重视社会经济综合发展的均衡性;某些发达省区的增速相对变缓,社会经济综合发展模式有待调整。 | Survey and Evaluation Center of China,Renmin University of China | 2009 | 中国人民大学学报2009，23，1： | 4 |
| 9 | 2015年全球医药行业预测,展望2020年(Ⅰ)显示文摘本期全球医药行业预测报告,汇集了Evaluate Pharma从多方面对行业的分析,从世界金融市场出发,全面展望2015至2020年间行业的预期表现。基于对世界5000强制药和生物技术公司的追踪分析,重点探讨处方药销售、专利风险、研发支出、全球品牌药物销售以及各治疗领域市场表现的趋势,同时简要回顾2014年行业表现。 | Evaluate Pharma | 2015 | 药学进展2015，39，8： | 3 |
| 10 | 2015年孤儿药研发分析报告(Ⅰ)显示文摘本期孤儿药研发分析报告,汇集了Evaluate Pharma的众多分析数据,从世界金融市场出发,高度洞察2015—2020年间值得期待的孤儿药市场。基于对世界5000强制药和生物技术公司的跟踪分析,重点探讨与解析作为处方药的孤儿药相对于非孤儿药的销售市场趋势、欧美对孤儿药的认定、相关产品和药企的表现、孤儿药Ⅲ期临床研发支出以及投资回报等。 | Evaluate Pharma 无 | 2016 | 药学进展2016，40，1： | 2 |
| 11 | Guidelines on clinical research evaluation of artificial intelligence in ophthalmology(2023)显示文摘With the upsurge of artificial intelligence(AI)technology in the medical field,its application in ophthalmology has become a cutting-edge research field.Notably,machine learning techniques have shown remarkable achievements in diagnosing,intervening,and predicting ophthalmic diseases.To meet the requirements of clinical research and fit the actual progress of clinical diagnosis and treatment of ophthalmic AI,the Ophthalmic Imaging and Intelligent Medicine Branch and the Intelligent Medicine Committee of Chinese Medicine Education Association organized experts to integrate recent evaluation reports of clinical AI research at home and abroad and formed a guideline on clinical research evaluation of AI in ophthalmology after several rounds of discussion and modification.The main content includes the background and method of developing this guideline,an introduction to international guidelines on the clinical research evaluation of AI,and the evaluation methods of clinical ophthalmic AI models.This guideline introduces general evaluation methods of clinical ophthalmic AI research,evaluation methods of clinical ophthalmic AI models,and commonly-used indices and formulae for clinical ophthalmic AI model evaluation in detail,and amply elaborates the evaluation methods of clinical ophthalmic AI trials.This guideline aims to provide guidance and norms for clinical researchers of ophthalmic AI,promote the development of regularization and standardization,and further improve the overall level of clinical ophthalmic AI research evaluations. | Wei-Hua Yang Yi Shao Yan-Wu Xu Expert Workgroup of Guidelines on Clinical Research Evaluation of Artificial Intelligence in Ophthalmology(2023) Ophthalmic Imaging and Intelligent Medicine Branch of Chinese Medicine Education Association Intelligent Medicine Committee of Chinese Medicine Education Association | 2023 | International Journal of Ophthalmology(English edition)2023，16，9： | 2 |
| 12 | Executive summary of the third report of the National Cholesterol Education Program(NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III ) 显示文摘 | Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults | 2001 | JAMA2001，285，19： | 1 |
| 13 | Executive summary of the third report of the national cholesterol education program expert panel on detection,evaluation,and treatment of high blood cholesterol in adults (adult treatment panelⅢ)显示文摘 | Evaluation and treatment of high blood cholesterol in adults | 2001 | JAMA2001，285，： | 1 |
| 14 | Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Perioperative Cardiovascular Evaluation for Noncardiac Surgery)显示文摘 | Guidelines for Perioperative Cardiovascular Evaluation for Noncardiac Surgery | 1996 | Circulation1996，93，： | 1 |
| 15 | (comments)显示文摘 | Johnson R E Dettre R H An evaluation of Neumanns Surface equation of state | 1989 | Langmuir1989，，5： | 1 |
| 16 | Comparison with positron emissiontomography values in chronic occlusion carotid disease显示文摘 | Kajimoto K Moriwaki H Yamada N ct al Cerebral he-modynamic evaluation using perfusion weighted magneticresonance imaging | 2003 | Stroke2003，34，7： | 1 |
| 17 | Fouling, chemical proper- ties and water chemistry on reverse osmosis rejection of seven ni- trosoalklyamines, including NDMA显示文摘 | Eva Steinle-Darling Marco Zedda Megan H Evaluating the impacts of membrane type coating | 2007 | Water Research2007，41，17： | 1 |
| 18 | Executive summary of the third report of the na- tional cholesterol education program (NCEP) expert panel on detec- tion, Evaluation, and treatment of high blood cholesterol in adults( A- dult Treatment Panel liI ) 显示文摘 | Expert Panel on Detection Evaluation and treatment of high bloodcholesterol in adults | 2001 | JAMA2001，285，19： | 1 |
| 19 | National Institutes of Health显示文摘 | Clinical guidelines on the identification evaluation and treatment of overweight and obesity in adults: the evidence report | 1998 | Obes Res1998，62，： | 1 |
| 20 | Component Testing, Characterization of Buckling-restrained Braces显示文摘 | Black C Makris N Aiken Seismic Evaluation and L | 2004 | Journal of Structural Engineering2004，130，6： | 1 |
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