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| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | Cerebellum and neurodegenerative diseases:Beyond conventional magnetic resonance imaging显示文摘The cerebellum plays a key role in movement control and in cognition and cerebellar involvement is described in several neurodegenerative diseases.While conventional magnetic resonance imaging(MRI) is widely used for brain and cerebellar morphologic evaluation,advanced MRI techniques allow the investigation of cerebellar microstructural and functional characteristics.Volumetry,voxel-based morphometry,diffusion MRI based fiber tractography,resting state and task related functional MRI,perfusion,and proton MR spectroscopy are among the most common techniques applied to the study of cerebellum.In the present review,after providing a brief description of each technique's advantages and limitations,we focus on their application to the study of cerebellar injury in major neurodegenerative diseases,such as multiple sclerosis,Parkinson's and Alzheimer's disease and hereditary ataxia.A brief introduction to the pathological substrate of cerebellar involvement is provided for each disease,followed by the review of MRI studies exploring structural and functional cerebellar abnormalities and by a discussion of the clinical relevance of MRI measures of cerebellar damage in terms of both clinical status and cognitive performance. | Enricomaria Mormina Maria Petracca Giulia Bommarito Niccolò Piaggio Sirio Cocozza Matilde Inglese | 2017 | World Journal of Radiology2017，9，10： | 5 |
| 3 | Hypertransaminasemia in the course of infection with SARS-CoV-2:Incidence and pathogenetic hypothesis显示文摘In patients infected with severe acute respiratory syndrome coronavirus 2,the respiratory symptoms,such as fever,cough and dyspnea,are the most frequent clinical manifestations.These patients may also present with less well-defined symptoms like diarrhea,nausea,vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical course.In a few cases,these symptoms may also present before the appearance of respiratory symptoms.To penetrate the body,Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors,which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver cholangiocytes.In several cases,viral RNA is detectable in the stool of patients with coronavirus disease 2019(COVID-19).The liver damage seems to show a multifactorial origin.About 2%-11%of patients with COVID-19 have known underlying hepatic pathologies.In 14%-53%of COVID-19 cases,there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19,especially during hospitalization. | Maddalena Zippi Sirio Fiorino Giuseppe Occhigrossi Wandong Hong | 2020 | World Journal of Clinical Cases2020，8，8： | 4 |
| 4 | A techno-economic and life cycle assessment for the production of green methanol from CO_(2): catalyst and process bottlenecks显示文摘The success of catalytic schemes for the large-scale valorization of CO_(2) does not only depend on the development of active,selective and stable catalytic materials but also on the overall process design.Here we present a multidisciplinary study(from catalyst to plant and techno-economic/lifecycle analysis)for the production of green methanol from renewable H2 and CO_(2).We combine an in-depth kinetic analysis of one of the most promising recently reported methanol-synthesis catalysts(InCo)with a thorough process simulation and techno-economic assessment.We then perform a life cycle assessment of the simulated process to gauge the real environmental impact of green methanol production from CO_(2).Our results indicate that up to 1.75 ton of CO_(2) can be abated per ton of produced methanol only if renewable energy is used to run the process,while the sensitivity analysis suggest that either rock-bottom H2 prices(1.5$kg1)or severe CO_(2) taxation(300$per ton)are needed for a profitable methanol plant.Besides,we herein highlight and analyze some critical bottlenecks of the process.Especial attention has been paid to the contribution of H2 to the overall plant costs,CH4 trace formation,and purity and costs of raw gases.In addition to providing important information for policy makers and industrialists,directions for catalyst(and therefore process)improvements are outlined. | Tomas Cordero-Lanzac Adrian Ramirez Alberto Navajas Lieven Gevers Sirio Brunialti Luis MGandía Andrés T.Aguayo S.Mani Sarathy Jorge Gascon | 2022 | Journal of Energy Chemistry2022，31，5： | 3 |
| 5 | Vitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis:a systematic review and meta-analysis显示文摘AIM To assess vitamin E efficacy,defined as its ability to induce hepatitis B e antigen(HBeAg) seroconversion,in children with HBeAg-positive persistent hepatitis.METHODS In July 2016,we extracted articles published in MEDLINE and the Cochrane Library using the following search terms:'chronic hepatitis B','children','childhood','therapy','treatment','vitamin E','tocopherols','tocotrienols'.Only randomized controlled trials(RCTs) published in English language were collected.RESULTS Three RCTs met inclusion criteria and were considered in the present meta-analysis.Overall,23/122 children in the treatment group underwent HBeAg seroconversion vs 3/74 in the control group(OR=3.96,95%CI:1.18-13.25,P=0.025).CONCLUSION Although our meta-analysis has several limits,including the very small number of available studies and enrolled children with HBeAg positivity-related hepatitis,it suggests that vitamin E use may enhance the probability to induce HBeAg seroconversion in these patients.Further well designed and adequately sized trials are required to confirm or deny these very preliminary results. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Paolo Leandri Elisabetta Loggi Pietro Andreone | 2017 | World Journal of Hepatology2017，9，6： | 2 |
| 6 | Assessment of spray deposition and recycling rate in the vineyard from a new type of air-assisted tunnel sprayer显示文摘 | Gianfranco Pergher Rino Gubiani Sirio R.S. Cividino Daniele Dell’Antonia Corrado Lagazio | 2013 | Crop Protection2013，，： | 2 |
| 7 | Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis显示文摘BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the world.Their consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these patients.These risks also appear to be linked to the duration and the dosage.On the other hand,several studies have emerged with regard to the protective or therapeutic effects of these drugs.More and more evidence underlines the immunomodulatory and anti-fibrotic role of PPIs.In addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host cells.AIM To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and mortality.METHODS A literature review was performed in November 2020.The MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this topic.The search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and keywords.The MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were excluded.We tried to summarize and pool all the data if available.RESULTS A total of 9 studies were found that described the use of PPIs,of which only 5 clearly reported the severity and mortality data in SARS-CoV-2 patients.Our pooled incidence analysis of severe events did not differ between patients with and without PPIs(odds ratio 1.65,95%confidence interval:0.62-4.35)(P=0.314),or for mortality(odds ratio 1.77,95%confidence interval:0.62-5.03)(P=0.286).CONCLUSION Detailed and larger case studies are needed to accurately understand the role of PPIs in this viral infection. | Maddalena Zippi Sirio Fiorino Roberta Budriesi Matteo Micucci Ivan Corazza Roberta Pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong | 2021 | World Journal of Clinical Cases2021，9，12： | 2 |
| 8 | Long-term mortality and quality of life after prolonged mechanical ventilation显示文摘 | Lakshmipathi Chelluri Kyung Ah Im Steven H. Belle Richard Schulz Armando J. Rotondi Michael P. Donahoe Carl A. Sirio Aaron B. Mendelsohn Michael R. Pinsky | 2004 | Critical Care Medicine2004，，： | 1 |
| 9 | Patient's recollec-tion of stressful experiences while receiving prolongedmechanical ventilation in an intensive care unit显示文摘 | Rotondi A J Chelluri L Sirio C | 2002 | CritCare Med2002，30，4： | 1 |
| 10 | Patients'recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit显示文摘 | Rotondi AJ Chelluri L Sirio C | 2002 | Crit Care M ed2002，30，： | 1 |
| 11 | Patients' recollections ofstress- ful experiences while receiving prolonged mechanical ventilation in an intensive care unit 显示文摘 | Rotondi A J Chelluri L Sirio C | 2002 | Critical Care Medicine2002，30，4： | 1 |
| 12 | A cross-cultural comparison of critical care delivery:Japan and the United States显示文摘 | Sirio CA Tajimi K Taenaka N | | 0，，： | 1 |
| 13 | Emilin1 Links TGF-β Maturation to Blood Pressure Homeostasis显示文摘 | Luca Zacchigna Carmine Vecchione Antonella Notte Michelangelo Cordenonsi Sirio Dupont Silvia Maretto Giuseppe Cifelli Alessandra Ferrari Angelo Maffei Carla Fabbro Paola Braghetta Gennaro Marino Giulio Selvetella Alessandra Aretini Claudio Colonnese Umber | 2006 | Cell2006，，5： | 1 |
| 14 | Day of the week of intensive care admission and patient outcomes:a multisite regional evaluation显示文摘 | Barnett MJ Kaboli PJ Sirio CA | | 0，，6： | 1 |
| 15 | Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit 显示文摘 | Rotondi A J Chelluri L Sirio C | 2002 | Crit Care Med2002，30，4： | 1 |
| 16 | The landfill reinjection of concentrated leachate: Findings from a monitoring study at an Italian site显示文摘 | Paolo S. Calabrò Silvia Sbaffoni Sirio Orsi Emiliano Gentili Carlo Meoni | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 17 | Patients' Recollections of Stressful Experiences While Receiving Prolonged Mechanical Ventilation in an Intensive Care Unit显示文摘 | Rotondi A J Chelluri L Sirio C | 2002 | Crit Care Med2002，30，4： | 1 |
| 18 | Patients'recollections of stressful experiences while receiving prolonged mechanical ventilati- on in an intensive care unit 显示文摘 | Rotondi AT Chelluri L Sirio C | 2002 | Critical Care Medicine2002，30，4： | 1 |
| 19 | Patients’ recollections ofstressful experiences while receiving prolonged mechanicalventilation in an intensive care unit显示文摘 | Rotondi A Chelluri L Sirio CA | 2002 | Crit Care Med2002，30，4： | 1 |
| 20 | Pat ients/ recol-lections of stressful experiences while receivingprolonged mechanical venfilation in an intensivecare unit显示文摘 | Rotondi AJ CheUuri L Sirio C | 2002 | Crit Care Med2002，30，4： | 1 |
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