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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | Postoperative impairment mucous transport in the lung 显示文摘 | Gamsu G Singer M M Vincent H H | 1976 | Am Rev Respir Dis1976，114，： | 2 |
| 3 | Transient source current formulation for the analysis of arbitrarily shaped dielectric/conducting composite structures 显示文摘 | Ramin A Singer H | 2010 | Engineering Analysis with Boundary Elements2010，34，5： | 1 |
| 4 | The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary corti- cal neurons 显示文摘 | SINGER C A FIGUEROA-MASOT X A BATCHELOR R H | 1999 | J Neurosci1999，19，7： | 1 |
| 5 | Understanding consumption-related sucralose emissions - A conceptual approach combining substance-flow analysis with sampling analysis 显示文摘 | Neset T S Singer H Longree P | 2010 | Sci Total Environ2010，408，16： | 1 |
| 6 | Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma- linolenic acid in ventilated patients with acute lung injury显示文摘 | Singer P Theilla M Fisher H | 2006 | Crit Care Med2006，34，4： | 1 |
| 7 | Occurrence and fate ofcarbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters 显示文摘 | Tixier C Singer H P Oellers S | 2003 | Environmental Science & Technology2003，37，6： | 1 |
| 8 | Creeping plumes 显示文摘 | Singer H | 1985 | Journal of Fluid Mechanics1985，158，： | 1 |
| 9 | The influence of hot working on the subsequent recrystallization oI a dispersion strengthened superalloy-MA 6000 显示文摘 | SINGER R F GESSINGER G H | 1982 | Metall Trans A1982，13，8： | 1 |
| 10 | Anti-inflammatory prop- erties of omega-3 fatty acids in critical illness: novel mecha- nisms and an integrative perspective 显示文摘 | Singer P Shapiro H Theilla M | 2008 | Intensive Care Med2008，34，9： | 1 |
| 11 | Fluorescence in situ hybridization: past, present and future 显示文摘 | Levsky J M Singer R H | 2003 | Journal of Cell Science2003，116，14： | 1 |
| 12 | Indoor pollutants emitted by office equipment: A review of re- ported data and information needs 显示文摘 | Destaillats H Maddalena R L Singer B C | 2008 | Atmospheric Environment2008，42，7： | 1 |
| 13 | First successful im plantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby显示文摘 | Zartner P Cesnjevar R Singer H | | 0，，04： | 1 |
| 14 | Bench-scale testing of a magnetic ion exchange resin for removal of disinfection by-product precursors 显示文摘 | Boyer T H Singer P C | 2005 | Water Res2005，39，7： | 1 |
| 15 | Manufactured Exports of Developing Countries and Their Terms of Trade since 1965 显示文摘 | Sarkar P Singer H | 1991 | World Development1991，19，4： | 1 |
| 16 | Health Insurance and Catastrophic Illness: A Report on the New Cooperative Medical System in Rural China 显示文摘 | Yi H Zhang L Singer K | 2009 | Health Economics2009，18，2： | 1 |
| 17 | Techniques of Low Pressure Chemical Vapor Deposition 显示文摘 | Singer P H | 1984 | Semiconductor International1984，7，5： | 1 |
| 18 | Anti-inflammatory properties of omega-3 fatty acids in critical illness:novel mechanisms and an integrative perspective显示文摘 | Singer P Shapiro H Theilla M | | 0，，9： | 1 |
| 19 | Social withdrawal afterlaryngectomy 显示文摘 | Danker H Wollbrlick D Singer S | 2010 | Eur Arch Otorhinolaryngol2010，267，4： | 1 |
| 20 | Beyond Terms of Trade: Convergence and Divergence 显示文摘 | Singer H W | 1999 | Journal of International Development1999，11，6： | 1 |
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