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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | Interaction between duct fires and ventilation flow-An experimental study显示文摘 | Lee C K Chaiken R F Singer J M | 1979 | Combust Sci Technol1979，20，： | 2 |
| 3 | Coexistence of occult vascular malformations and developmental venous anomalies in the central nervous system: MR evaluation 显示文摘 | Abe T Singer R J Marks MP | 1998 | Am J Nenroradiol1998，19，： | 1 |
| 4 | In vitro antimicrobial activity against 10 North American and European Lawsonia intracellularis isolates显示文摘 | WATTANAPHANSAK S SINGER R S GEBHART C J | 2009 | Vet Microbiol2009，134，34： | 1 |
| 5 | Fluorescence in situ hybridization: past, present and future 显示文摘 | Levsky J M Singer R H | 2003 | Journal of Cell Science2003，116，14： | 1 |
| 6 | Intramedullary nailing for the treatment of dislocated pedi- atric radial neck fractures 显示文摘 | Eberl R Singer G Fruhmann J Saxena A Hoellwarth ME | 2010 | Eur J Pediatr Surg2010，20，4： | 1 |
| 7 | The Impact of Corporate Social Responsiveness on Shareholder Wealth 显示文摘 | Holman W R New J R Singer D | 1985 | Research in Corporate Social Performance and Policy1985，，7： | 1 |
| 8 | CVD-diamond single-crystal growth 显示文摘 | Schwarz S Rottmair C Hirmke J Rosiwal S Singer R F | 2004 | Journal of Crystal Growth2004，271，： | 1 |
| 9 | The sleep disorders invcnroty an instrument for studiees of sleep disturbancc in persons with Alzheimets disease 显示文摘 | TRACTEN BENG R E SINGER C M CUMMINGS J L | 2003 | J Sleep Res2003，12，4： | 1 |
| 10 | Computer Control of Multiple-Site Track Correlation 显示文摘 | Singer R A Kanyuck A J | 1971 | Automation1971，7，： | 1 |
| 11 | Cutaneous wound healing 显示文摘 | Singer A J Clark R A | 1999 | N Engl J Med1999，341，： | 1 |
| 12 | Haeraodgnamic evidence for cardic stress during lransurethd prostatectomy显示文摘 | Evans J W Singer M Chapple C R | 1992 | BMJ1992，304，6828： | 1 |
| 13 | Spatial variability of wheat yield and soil properties on complex hills显示文摘 | Miller P M Singer M J Nielsen D R | 1988 | Soil Science Society of America Journal1988，52，： | 1 |
| 14 | The Influences of Salaries and “Opportunity Costs”on Teachers’Career Choices:Evidence from North Carolina显示文摘 | Murnane R Singer J Willett J | | 0，，3： | 1 |
| 15 | Uncemented total hip arthropl inosteonecrosis:a 2-to 10-year evalution显示文摘 | Stulberg BN Singer R Goldner J | 1997 | Clin Orthop Relat Res1997，，334： | 1 |
| 16 | The tight calorie control study (TI-CACOS) : a prospective, randomized, controlled pilot study of nutri-tional support in critically ill patients显示文摘 | Singer P Anbar R Cohen J | 2011 | Intensive Care Med2011，37，4： | 1 |
| 17 | Winter cereal canopy effect on cereal and interseeded legume productivity 显示文摘 | Blaser B C Singer J W Gibson L R | 2011 | Agronomy Journal2011，103，4： | 1 |
| 18 | Fluorescence in situ hybridization:past, present and Future显示文摘 | Levsky J M Singer R H | 2003 | Journal of Cell Science2003，116，： | 1 |
| 19 | Conjugation of camptothecins to poly-(L-glutamic acid) 显示文摘 | Singer J W Devries P Bhatt R | 2000 | Ann Nat Y Acad Sci2000，922，： | 1 |
| 20 | Empathic Neural Responses are Modulated by the PerceivedFairness of Others 显示文摘 | Singer T Seymour B 0 ’ Doherty J P Stephan K E Dolan R J FrithC D | 2006 | Nature2006，，439： | 1 |
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