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| 1 | PROGRESS AND PROSPECTS IN CORPUS LINGUISTICS显示文摘 | JOHN SINCLAIR | 2004 | 现代外语2004，27，2： | 15 |
| 2 | Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist显示文摘AIM To investigate the impact of physical frailty on risk of hospitalisation in cirrhotic patients on the liver transplant waitlist.METHODS Cirrhotics listed for liver transplantation at a single centre underwent frailty assessments using the Fried Frailty Index, consisting of grip strength, gait speed, exhaustion, weight loss, and physical activity. Clinical and biochemical data including MELD score as collected at the time of assessment. The primary outcome was number of hospitalised days per year; secondary outcomes included incidence of infection. Univariable and multivariable analysis was performed using negative binomial regression to associate baseline parameters including frailty with clinical outcomes and estimated incidence rate ratios(IRR). RESULTS Of 587 cirrhotics, 64% were male, median age(interquartile range) was 60(53-64) years and MELD score was 15(12-18). Median Fried Frailty Index was 2(1-3); 31.6% were classified as frail(fried frailty ≥ 3). During 12 mo of follow-up, 43% required at least 1hospitalisation; 38% of which involved major infection.107/184(58%) frail and 142/399(36%) non-frail patients were hospitalised at least once(P < 0.001). In univariable analysis, Fried Frailty Index was associated with total hospitalisation days per year(IRR = 1.51,95%CI: 1.28-1.77; P ≤ 0.001), which remained significant on multivariable analysis after adjustment for MELD, albumin, and gender(IRR for frailty of 1.21,95%CI: 1.02-1.44; P = 0.03). Incidence of infection was not influenced by frailty.CONCLUSION In cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity. | Marie Sinclair Eduard Poltavskiy Jennifer L Dodge Jennifer C Lai | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 3 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 4 | 老年2型糖尿病管理全球指南显示文摘国际糖尿病联盟(IDF)在2013年发布了《老年2型糖尿病管理全球指南》.从本期开始我们将连载该指南的中文译文,希望对广大医务工作者有所帮助。 | Alan Sinclair Trisha Dunning Stephan Colagiuri 罗燮 | 2014 | 糖尿病天地(临床)2014，8，2： | 9 |
| 5 | Malnutrition in cirrhosis:More food for thought显示文摘Malnutrition is highly prevalent in liver cirrhosis and its presence carries important prognostic implications.The clinical conditions and pathophysiological mechanisms that cause malnutrition in cirrhosis are multiple and interrelated.Anorexia and liver decompensation symptoms lead to poor dietary intake;metabolic changes characterised by elevated energy expenditure,reduced glycogen storage,an accelerated starvation response and protein catabolism result in muscle and fat wasting;and,malabsorption renders the cirrhotic patient unable to fully absorb or utilise food that has been consumed.Malnutrition is therefore a considerable challenge to manage effectively,particularly as liver disease progresses.A high energy,high protein diet is recognised as standard of care,yet patients struggle to follow this recommendation and there is limited evidence to guide malnutrition interventions in cirrhosis and liver transplantation.In this review,we seek to detail the factors which contribute to poor nutritional status in liver disease,and highlight complexities far greater than“poor appetite”or“reduced oral intake”leading to malnutrition.We also discuss management strategies to optimise nutritional status in this patient group,which target the inter-related mechanisms unique to advanced liver disease.Finally,future research requirements are suggested,to develop effective treatments for one of the most common and debilitating complications afflicting cirrhotic patients. | Brooke Chapman Marie Sinclair Paul J Gow Adam G Testro | 2020 | World Journal of Hepatology2020，12，11： | 8 |
| 6 | The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?显示文摘当跟随主要人的 cytomegalovirus (HCMV ) 感染的主人免疫者反应在停止病毒复制和传播通常是有效的时,病毒从来没被主人并且象所有 herpesviruses 一样清除,永久坚持。至少部分地,这坚持被知道被 HCMV 的能力便于在感染是实质上沉默的与的 myeloid 在房间建立潜伏,重要地新病毒生产的全部的缺乏。然而,尽管病毒的抄写计划很在潜伏期间被压制,很多病毒的基因在蛋白质水平在潜伏的感染期间被表示,这些中的许多被显示了在潜伏的房间和它的环境上有深刻效果。有趣地,许多也在 lysin 的感染期间这些联系潜伏的基因被表示。因此,一样的有势力主人免疫者回答为什么在 lysin 的感染期间产生了到这些病毒的基因产品,没在潜伏期间被认出,从而允许隐而不见地的感染的房间的清理,是远非清楚的。从潜伏的复活也是调停 HCMV 的疾病的一个主要原因,特别地在损害的免疫者和免疫者天真,并且也是可能的是在被建议了与象动脉粥样硬化和一些瘤形成那样的长期的疾病被联系的长期的无临床症状的 HCMV 感染的病毒的主要来源。因而,理解潜伏并且隐而不见地的感染的房间为什么看起来是 immunoprivileged,为 HCMV 的致病的理解是关键的并且可以帮助设计策略消除潜伏的病毒水库,至少在某些临床的背景。 | Mark R Wills Emma Poole Betty Lau Ben Krishna John H Sinclair | 2015 | Cellular & Molecular Immunology2015，12，2： | 6 |
| 7 | 新商业时代茶叶企业应对电子商务“再中间化”策略研究显示文摘新商业时代,天猫、京东等线上超市产生,无人超市Taocafe落地,正重构以'人、货、场'等为传统商业要素的线下超市。互联网造就电子商务再中间化,并影响传统企业供应链管理。研究根据京东网145家店铺890个祁门红茶产品和天猫网151家店铺986个祁门红茶产品的销售数据,实证研究新商业时代茶叶企业应对电子商务'再中间化'策略。结果表明,祁门红茶类目的电子商务,20%店铺占据80%市场,80%店铺处于'不乐观'状态,仅占20%市场,线上超市'再中间化'趋势明显。新商业时代茶叶企业应对电子商务'再中间化'可持续竞争力在于:对接线上超市,加强营销链接强度,加强内容合作深度,扩大产品品类,探索产地直销模式。 | 吴自爱 Paul Sinclair 王剑程 柳思维 | 2017 | 农业经济与管理2017，，4： | 4 |
| 8 | A review of solar type Ⅲ radio bursts显示文摘Solar type Ⅲ radio bursts are an important diagnostic tool in the understanding of solar accelerated electron beams. They are a signature of propagating beams of nonthermal electrons in the solar atmosphere and the solar system. Consequently, they provide information on electron acceleration and transport, and the conditions of the background ambient plasma they travel through. We review the observational properties of type Ⅲ bursts with an emphasis on recent results and how each property can help identify attributes of electron beams and the ambient background plasma. We also review some of the theoretical aspects of type Ⅲ radio bursts and cover a number of numerical efforts that simulate electron beam transport through the solar corona and the heliosphere. | Hamish Andrew Sinclair Reid Heather Ratcliffe | 2014 | Research in Astronomy and Astrophysics2014，14，7： | 4 |
| 9 | Pharmacokinetic and toxicity study of intravitreal erythropoietin in rabbits显示文摘瞄准:为潜在的临床的使用学习 intravitreal erythropoietin (EPO ) 的 pharmacokinetics 和毒性。方法:为毒性学习,有 EPO 的 intravitreal 注射(IVit ) 的 4 个组(60 只兔子) 被学习(10U, 100U,或 1 000U ) 每为单个注射的眼睛和为每月的注射的 0.6 U/eye (在兔子的设计治疗学的水平)(6 ×) 。眼睛检查,闪光网膜电图(尔格) ,和荧光黄 angiography (FA ) 在注射前后被执行。兔子在不同间隔为组织学的学习被打死。为 pharmacokinetic 学习,在进左眼睛的 5 U EPO 的 IVit 以后, 44 只兔子在不同间隔,和 EPO 层次被打死在玻璃,水,视网膜和浆液被连接酶的免疫分析吸着剂试金。结果:根本,时间,点检验了,眼睛在正常限制以内。没有重要尔格或 FA 变化被观察。视网膜的组织学仍然保持未改变。在眼睛的分隔空间的 EPO 的 pharmacokinetic 侧面如下被总结。EPO 在的半衰期时间玻璃,水并且浆液分别地是 2.84, 3.24 和 2.12 d;并且 C 最大 分别地是 4615.75, 294.31 和 1.60 U/L。在注射眼睛的视网膜的 EPO 集中在 6 h 追随者注射在 1.36 U/g 蛋白质达到顶点,与观察是 3.42 d 的半衰期。结论:在一个宽范围的 EPO 的 IVit 很好被容忍,为兔子的保险箱看。在直到比治疗学的层次高的 10 褶层的剂量, EPO 与更快的清理有 pharmacokinetic 侧面,它为阵发性的 IVit 是有利的。 | Jing-fa ZHANG Ya-lan WU Jing-ying XU Wen YE Yu ZHANG Huan WENG Wo-dong SHI Guo-xu XU Luo LU Wei DAI Stephen H SINCLAIR Wei-ye LI Guo-tong XU | 2008 | Acta Pharmacologica Sinica2008，29，11： | 4 |
| 10 | The effects of selection for cold tolerance on cross-tolerance to other environmental stressors in Drosophila melanogaster显示文摘抽象生气忍耐,到一个环境压力的忍耐由此与忍耐被相关到另外的压力 ors,被认为在昆虫普遍。我们使用了果蝇 melanogaster Meigen 的线(双翅目:Drosophilidae ) 在 1-h 暴露为幸存选择了到 −5 ° C 检验这种选择导致到增加的公差到另外的压力的程度包括高、低的温度,干燥和饥饿。当选择在 −5 ° C 改进了忍耐到尖锐冷暴露和幸存时,有到另外的压力 ors 的忍耐上的选择政体的小效果。在到任何应力 ors 的忍耐之间没有关联,建议公差的不同机制。这支持争论在压力忍耐之间的关联在有 D 的选择实验期间。melanogaster 可能是巧合的。大小变硬热被基础忍耐显然在线之中抑制,但是快速的冷变硬的反应的大小没与基础冷忍耐被相关,暗示在可诱导、基础的忍耐之间的关系在高、低的温度不同。 | Heath A. MacMillan Jillian P. Walsh Brent J. Sinclair | 2009 | Insect Science2009，16，3： | 3 |
| 11 | An unsolved conundrum: the ideal follow-up strategy after curative surgery for colorectal cancer显示文摘 | Piriyah Sinclair Anjana Singh Amjid A. Riaz Alla Amin | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 12 | Uncovering the Extent of the Phraseological Tendency: Towards a Systematic Analysis of Concgrams显示文摘 | Winnie Cheng Chris Greaves John McH. Sinclair Martin Warren | 2009 | Applied Linguistics2009，，2： | 2 |
| 13 | Development of a Questionnaire to Measure the Level of Reflective Thinking显示文摘 | David Kember Doris Y. P. Leung Alice Jones Alice Yuen Loke Jan McKay Kit Sinclair Harrison Tse Celia Webb Frances Kam Yuet Wong Marian Wong Ella Yeung | 2000 | Assessment & Evaluation in Higher Education2000，，4： | 2 |
| 14 | Is there evidence of selection in the dopamine receptor D4 gene in Australian invasive starling populations?显示文摘 | Lee Ann ROLLINS Michael R. WHITEHEAD Andrew R WOOLNOUGH Ron SINCLAIR William B. SHERWIN | 2015 | Current Zoology2015，61，3： | 2 |
| 15 | Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer显示文摘The relationship between vitamin D metabolic enzymes (CYP27A1, CYP27B1, and CYP24A1) and vitamin D receptor (VDR) in nonmelanoma skin cancer (NMSC) development and progression is not entirely clear. However, several clinical studies and in vitro reports indicate a connection between vitamin D metabolic key players and NMSCs by demonstrating inhibitory effects on tumor cells and positive effects in skin cancer prevention of higher circulatory 25-hydroxyvitamin D [1]. Vitamin D synthesis is mediated via mitochondrial cytochrome P450 family hydroxylase enzymatic reactions: anabolic and catabolic hydroxylases (CYP27A1, CYP27B1, and CYP24A1). | Natalie Nemazannikova Gregory L. Blatch Crispin R. Dass Rodney Sinclair Vasso Apostolopoulos | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 2 |
| 16 | Health Maintenance in the Inflammatory Bowel Disease Patient显示文摘 | Jennifer A. Sinclair Sharmeel K. Wasan Francis A. Farraye | 2012 | Gastroenterology Clinics of North America2012，，2： | 2 |
| 17 | Metabolic response of sheep skin to a chronic infusion of a variant of insulin-like growth factor Ⅰ显示文摘 | Hocking Edwards J E Khalaf S K Sinclaire B R | 1995 | Biochem J1995，308，2： | 1 |
| 18 | Effect of protozoan predation on relative abundance of fast- and slow-growing bacteria 显示文摘 | Sinclair J L Alexander M | 1989 | Can J Microbiol1989，35，5： | 1 |
| 19 | Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells 显示文摘 | Hartigan-O' Connor D J Poon C Sinclair E | 2007 | J Immunol Methods2007，319，12： | 1 |
| 20 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘 | Berta P Palmer MS | 1990 | Nature1990，346，6218： | 1 |
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