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177篇 您的检索式:作者名="Berta P"
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1Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments显示文摘The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies.Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López 2023Neural Regeneration Research2023,18,9:3
2A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘 Berta P Palmer MS 1990Nature1990,346,6218:1
3A gene from the human sex determining region encodes a protein with homology to a conserved DNA binding motif显示文摘Sinclau AH Berta P Palmer MS 1990Nature1990,346,:1
4A gene from the human sex-determining region encodes a protein with homology to a conserved DNA binding motif显示文摘Sinclair A H Berta P Palmer M S 1990Nature1990,346,:1
5A gene from the human sex-determining region encodes aprotein with homology to a conserved DNA-binding motif显示文摘Sinclair AH Berta P 1990Nature1990,346,:1
6A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘Sinclair A H Berta P Palmer M S 1990Nature1990,346,:1
7A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif 显示文摘Sinclair A H Berta P Palmer M S 1990Nature1990,346,:1
8A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘Sinclair AH Berta P Palmer MS 1990Nature1990,346,6281:1
9Genome-wide analysis of Sox genes in Drosophila melanogaster 显示文摘Cremazy F Berta P Girard F 2001Mech Dev2001,109,:1
10An experimental and numerical investigation of n-heptane/air counter-flow partially premixed flames and emission of NOx and PAH species显示文摘Berta P Aggarwal S K Purl I K 2006Combustion and Flame2006,145,4:1
11A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif 显示文摘Sinclair AH Berta P Palmer MS 1990Nature1990,346,6281:1
12A gene from the human sex-determining region encode a protein with homology to a conserved DNA-binding motif显示文摘Sinclair A H Berta P Palmer M S 1990Nature1990,346,:1
13Expression pattern of the Sox31 gene during zebrafish embryonic development显示文摘Girard F Crmazy F Berta P 2001Mech Dev2001,100,1:1
14Protein-A immunoadsorption in immunosuppression-resistant myasthenia gravis显示文摘Antozzi C Berta E Confalonieri P 1994Lancet1994,343,8889:1
15Sox neuro, a new Drosophila Sox gene expressed in the developing central nervous system 显示文摘Cremazy F Berta P Girard F 2000Mech Dev2000,93,12:1
16A gene from the human sex- determining region encodes a protein with homology to a conserved DNA-binding motif 显示文摘Sinclair A H Berta P Palmer M S 1990Nature1990,346,:1
17A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘Sinclair AH Berta P 1990Nature1990,346,:1
18A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘Sinclair A H Berta P Palmer M S 1990Nature1990,346,6281:1
19A gene form the human sex- determining region encodes a protein with homology to a cnsered DNA- binding motif显示文摘Sinclair A H Berta P Palmer M S 1990Nature1990,346,:1
20A gene from the human sex-deteriming region encodes a protein with homology to a conserved DNA-binding motif显示文摘Sinclair A H Berta P Palmer M S 1990Nature1990,346,:1
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