|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?显示文摘The kallikrein-kinin system(KKS) is an intricate endogenous pathway involved in several physiological and pathological cascades in the brain. Due to the pathological effects of kinins in blood vessels and tissues, their formation and degradation are tightly controlled. Their components have been related to several central nervous system diseases such as stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy and others. Bradykinin and its receptors(B1R and B2R) may have a role in the pathophysiology of certain central nervous system diseases. It has been suggested that kinin B1R is up-regulated in pathological conditions and has a neurodegenerative pattern, while kinin B2R is constitutive and can act as a neuroprotective factor in many neurological conditions. The renin angiotensin system(RAS) is an important blood pressure regulator and controls both sodium and water intake. AngⅡ is a potent vasoconstrictor molecule and angiotensin converting enzyme is the major enzyme responsible for its release. AngⅡ acts mainly on the AT1 receptor, with involvement in several systemic and neurological disorders. Brain RAS has been associated with physiological pathways, but is also associated with brain disorders. This review describes topics relating to the involvement of both systems in several forms of brain dysfunction and indicates components of the KKS and RAS that have been used as targets in several pharmacological approaches. | Maria da Graa Naffah-Mazzacoratti Telma Luciana Furtado Gouveia Priscila Santos Rodrigues Simōes Sandra Regina Perosa | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 3 | Experimental behavior of a steel structure under natural fire 显示文摘 | Wald F Sim?es da Silva L Moore D B | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 4 | Human mesenchymal stem cells from the umbilical cord matrix: Successful isolation and ex vivo expansion using serum‐/xeno‐free culture media显示文摘 | Irina N. Sim?es Joana S. Boura Francisco dos Santos Pedro Z. Andrade Carla M. P. Cardoso Jeffrey M. Gimble Cláudia L. da Silva Joaquim M. S. Cabral | 2013 | Biotechnology Journal2013，，4： | 1 |
| 5 | The electronic properties of sputtered chromium and iron oxide films显示文摘 | G Goodlet S Faty S Cardoso P.P Freitas A.M.P Sim?es M.G.S Ferreira M Da Cunha Belo | 2003 | Corrosion Science2003，，6： | 1 |
| 6 | Experimental behavior of a steel structure under natural fire显示文摘 | Wald F Sim?es da Silva L Moore D B | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 7 | Sodium metabisulfite and sulfur dioxide release:An under recognizedhazard among shrimp fishermen显示文摘 | Atkinson DA Sim TC Grant JA | 1993 | Ann Allergy1993，71，： | 1 |
| 8 | Prevalence of nondiabetic renal disease in diabetic patients显示文摘 | Pham TT Sim JJ Kujubu DA | | 0，，03： | 1 |
| 9 | Sleep apnea in early and advanced chronic kidney disease:Kaiser Permanente Southern California cohort显示文摘 | Sim JJ Rasgon SA Kujubu DA | 2009 | Chest2009，135，3： | 1 |
| 10 | Relationships between leaf pigment content and spectral reflectance across a wide range of species, leaf structures and developmental stages显示文摘 | SIMS DA Gamon JA | 2002 | Remote Sensing of Environment2002，81，23： | 1 |
| 11 | Prevalence of nondiabetic renal dis-ease in diabetic patients显示文摘 | Pham TT Sim JJ Kujubu DA | | Am J Nephrol 207 27(3)0，300，： | 1 |
| 12 | Relationships between leaf pigment content and spectral reflectance across a wide range of species, leaf structures and developmental stages显示文摘 | Sims DA Gamon JA | 2002 | Remote Sensing of Environment2002，81，： | 1 |
| 13 | I Intercomparison of recruitment m - aneuver ef- ficacy in three models of acute lung injury 显示文摘 | Lim SC Adam a AB Sim onson DA eta | 2004 | Crit Care Med2004，32，： | 1 |
| 14 | Molecular characterization of Cryptosporidium spp. from fecal samples of birds kept in captivity in Brazil显示文摘 | Alex Akira Nakamura Daniel Castendo Sim?es R?mulo Godik Antunes Deuvania Carvalho da Silva Marcelo Vasconcelos Meireles | 2009 | Veterinary Parasitology2009，，1： | 1 |
| 15 | Relationships between leaf pigment content and spectral reflectance across a wide range of species,leaf structures and developmental stages显示文摘 | Sims DA Gamon JA | | 0，，2： | 1 |
| 16 | The effectiveness of endometrial ablation with the hydro therm ablator(HTA)for abnormal uterine bleeding显示文摘 | Iglesias DA Madani Sims S Davis JD | 2010 | Am J Obstet Gynecol2010，202，6： | 1 |
| 17 | Reevaluating the definition of intraretinal microvascular abnormalities and neovascularization elsewhere in diabetic retinopathy using optical coherence tomography and fluorescein angiography 显示文摘 | Lee CS Lee AY Sim DA | 2015 | Am J Ophthalmol2015，159，1： | 1 |
| 18 | Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice显示文摘 | Kathryn A.B. Sim?o da Silva Ana F. Paszcuk Giselle F. Passos Eduardo S. Silva Allisson Freire Bento Flavia C. Meotti Jo?o B. Calixto | 2011 | Pain2011，，8： | 1 |
| 19 | Para-metric analysis of the latera-l torsional buckling resistance ofsteel beams in case of fire显示文摘 | P M M Vila Real N Lopes L Sim es da Silva | 2007 | Fire Safety Journal2007，42，67： | 1 |
| 20 | Prevalence of nondiabetic renal disease in diabetic patients显示文摘 | Pham TT Sim J J Kujubu DA | 2007 | Am J Nephrol2007，27，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员