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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification显示文摘AIM:To study whether selected bacterial 16S ribosomal RNA(rRNA)gene phylotypes are capable of disting- uishing irritable bowel syndrome(IBS). METHODS:The faecal microbiota of twenty volunteers with IBS,subdivided into eight diarrhoea-predominant (IBS-D),eight constipation-predominant(IBS-C)and four mixed symptom-subtype(IBS-M)IBS patients,and fifteen control subjects,were analysed at three time-points with a set of fourteen quantitative real-timepolymerase chain reaction assays.All assays targeted 16S rRNA gene phylotypes putatively associated with IBS,based on 16S rRNA gene library sequence analysis. The target phylotypes were affiliated with Actinobac-teria,Bacteroidetes and Firmicutes.Eight of the target phylotypes had less than 95%similarity to cultured bacterial species according to their 16S rRNA gene sequence.The data analyses were made with repeated-measures ANCOVA-type modelling of the data and principle component analysis(PCA)with linear mixed-effects models applied to the principal component scores. RESULTS:Bacterial phylotypes Clostridium cocleatum 88%,Clostridium thermosuccinogenes 85%,Coprobacillus catenaformis 91%,Ruminococcus bromii-like, Ruminococcus torques 91%,and R.torques 93%were detected from all samples analysed.A multivariate analysis of the relative quantities of all 14 bacterial 16S rRNA gene phylotypes suggested that the intestinal microbiota of the IBS-D patients differed from other sample groups.The PCA on the first principal component(PC1),explaining 30.36%of the observed variation in the IBS-D patient group,was significantly altered from all other sample groups(IBS-D vs control, P=0.01;IBS-D vs IBS-M,P=0.00;IBS-D vs IBS-C, P=0.05).Significant differences were also observed in the levels of distinct phylotypes using relative values in proportion to the total amount of bacteria.A phy- lotype with 85%similarity to C.thermosuccinogenes was quantified in significantly different quantities among the IBS-D and control subjects(-4.08±0.90 vs -3.33±1.16,P=0.04)and IBS-D and IBS-M subjects (-4.08±0.90 vs-3.08±1.38,P=0.05).Furthermore,a phylotype with 94%similarity to R.torques was more prevalent in IBS-D patients'intestinal micro- biota than in that of control subjects(-2.43±1.49 vs -4.02±1.63,P=0.01).A phylotype with 93%simi- larity to R.torques was associated with control sam- ples when compared with IBS-M(-2.41±0.53 vs -2.92±0.56,P=0.00).Additionally,a R.bromii-like phylotype was associated with IBS-C patients in com- parison to control subjects(-1.61±1.83 vs-3.69± 2.42,P=0.01).All of the above mentioned phylotype specific alterations were independent of the effect of time. CONCLUSION:Significant phylotype level alterationsin the intestinal microbiotas of IBS patients were observed,further emphasizing the possible contribution of the gastrointestinal microbiota in IBS. | Anna Lyra Teemu Rinttil Janne Nikkil Lotta Krogius-Kurikka Kajsa Kajander Erja Malinen Jaana Mtt Laura Mkel Airi Palva | 2009 | World Journal of Gastroenterology2009，15，47： | 26 |
| 3 | Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis显示文摘 | Kang KB Wang TT Woon CT Cheah ES Moore XL Zhu C Wong MC | 2007 | 中国神经肿瘤杂志2007，5，2： | 8 |
| 4 | 醛固酮可通过NLRP3炎症小体诱导小鼠肝星状细胞活化和肝纤维化显示文摘【据《J Gastroenterol Hepatol》2020年6月报道】题:醛固酮通过NLRP3炎症小体诱导小鼠肝星状细胞活化和肝纤维化(作者Li Y等)已有证据表明,醛固酮和NLRP3炎症小体是诱导肝星状细胞活化以及肝纤维化的重要因素。然而,醛固酮与NLRP3炎症小体在肝星状细胞激活以及肝纤维化过程中是否存在相互作用,目前尚不清楚。该研究旨在探讨醛固酮与NLRP3炎症小体在调控肝星状细胞活化以及肝纤维化形成过程中的相互作用关系。 | LI Y ZHANG YJ CHEN TT 李洋 李旭 | 2020 | 临床肝胆病杂志2020，36，8： | 7 |
| 5 | 一步浸渍合成具有多重孔隙的铸型炭体(英文)显示文摘 以多孔块状硅体为模板,通过一步浸渍、炭化、酸处理工艺,制备出结构可控、孔隙联通且具有多重孔隙的铸型炭体。分别采用氮吸附技术、高分辨透射电镜和扫描电镜对模板硅、硅碳复合物及相应炭体进行了结构表征。从微米尺度分析,该炭体是由高度联接的枝状结构单元为骨架构筑而成。与模板硅相比较,此炭体是硅体的正复本。从纳米尺度分析,这种炭体枝状骨架是由分布均匀且相互连接的中孔构成,此中孔及其孔壁对应于模板硅的孔壁及中孔,是多孔硅的负复本。此外构成中孔的炭骨架本体又含有大量炭化过程产生的微孔。因此该法合成的铸型炭具有孔隙高度发达和结构层层嵌套的特点。 | 陆安慧 Jan-Henrik Smtt Mika Lindn Ferdi Schüth | 2003 | 新型炭材料2003，18，4： | 6 |
| 6 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 7 | 颈总动脉内径与心血管事件及死亡风险研究:4项队列研究的汇总分析显示文摘颈动脉内径增加是动脉重构的表现,且可能是心血管病的危险因素。研究者评估颈动脉内径与脑卒中、冠状动脉性心脏病、心血管病及全因死亡的关系,并探讨与血压有关的中膜增厚、动脉僵硬、动脉壁应力及动脉硬化等动脉重构过程能否解释此关系。 | Sedaghat S van Sloten TT Laurent S London GM Pannier Kavousi M Mattace-Raso F Franco OH Boutouyrie P Ikram MA Stehouwer CDA 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，7： | 4 |
| 8 | 当今关于不稳定型心肌缺血的概念显示文摘不稳定型心肌缺血在临床、化学、血管造影和病理学方面有明确的特征,据此提出了合适的治疗措施。 | Bashour TT 黄震华 | 1989 | 国外医学(心血管疾病分册)1989，16，1： | 4 |
| 9 | Entrepreneurs innovation bringing job satisfaction,work-family balance,and life satisfaction:In China and around the world显示文摘Entrepreneurs work such,as innovation,may bring financial benefits and non-pecuniary benefits,such as well-being.Entrepreneurial innovation expectedly benefits an individuals job satisfaction,balance between work and family,and life satisfaction.This is tested for entrepreneurs in China and around the world,with a globally representative sample of 33,519 entrepreneurs,including 786 in China.Among entrepreneurs around the world,innovation benefits job satisfaction,the balance between work and family,and life satisfaction.In China,specifically,entrepreneurs innovation also benefits their satisfaction with the balance between work and family and with life. | Kent Wickstrøm Jensen Ye Liu Thomas Schøtt | 2017 | International Journal of Innovation Studies2017，1，4： | 2 |
| 10 | 血压变异性加大与认知功能减退相关显示文摘由于预期寿命增加,越来越多的人将面临与增龄相关的认知困难。因此,确定认知障碍的可改变的风险因素非常重要。极短期到中期的血压变异性(blood pressure variability,BPV)可能就是这样一个因素,因为它可能导致脑缺血。 | Zhou TL Kroon AA van Sloten TT van Boxtel MPJ Verhey FRJ Schram MT Kohler S Stehouwer CDA Henry RMA 刘莉(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 11 | Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features显示文摘 | Thwaites GE Chau TT Stepniewska K et a1 | 2002 | Lancet2002，360，9342： | 2 |
| 12 | Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat显示文摘Background:Current animal models of chronic pancreatitis(CP)often provide only limited pathophysio-logical insights since they incompletely reflect the human disease.CP induced by injection of dibutyltin dichloride(DBTC-pancreatitis)shares with human CP the important feature of extended fibrosis and would be an even more attractive model if it could be transferred from rats to mice,as recently sug-gested in the context of combined ethanol and DBTC application.This study aimed to evaluate the effects of DBTC in pancreas and liver of C57BL/6 mice,a strain commonly used to engineer genetic mouse mod-els.Methods:C57BL/6 mice and Lewis rats were exposed to variable doses of DBTC.After an investigation period of up to 4 weeks,laboratory findings and histopathological changes of pancreas and liver were evaluated.Results:Chronic DBTC-pancreatitis in rats was characterized by acinar cell damage,ductal changes,fi-brosis,and inflammatory cell infiltrates.Mice treated with DBTC at 6–8 mg/kg body weight,the standard doses in rats,showed transient increases of lipase activities but no morphological signs of chronic DBTC-pancreatitis 4 weeks after injection of the drug.Increased doses of 10–12 mg/kg DBTC were intolerable due to their high toxicity.In contrast,mice and rats presented with a similar histopathology of the liver that can be characterized as a chronic-proliferative DBTC-cholangitis with predominating damage and proliferation of the small bile ducts as well as secondary portal inflammatory cell infiltrates and a begin-ning portal fibrosis.Conclusions:The DBTC-model cannot be transferred from rats to C57BL/6 mice with respect to chronic DBTC-pancreatitis,but might be of interest to study DBTC-cholangitis in both species. | Friederike Lütt Luise Ehlers Horst Nizze Robert Jaster | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 2 |
| 13 | 不同膳食蛋白摄入量与男性心力衰竭风险的关系:Kuopio缺血性心脏病风险因子研究显示文摘已证实动物和植物蛋白摄入量与心血管病死亡风险有相反的相关性,但膳食蛋白是否与心力衰竭风险相关尚不清楚。为此,Virtanen等研究了不同食物来源的蛋白与心力衰竭风险的关系。研究包括了1984-1989年在Kuopio缺血性心脏病风险因子研究中基线年龄42-60岁的男性2441人,根据4d的膳食记录评估基线时的蛋白质摄入量,自国家登记处获取心力衰竭病例的数据。 | 刘莉 叶鹏 Virtanen HEK Voutilainen S Koskinen TT Mursu J Tuomainen TP Virtanen JK | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 14 | Total gastrectomy severely alters the central regulation of food intake in rats 显示文摘 | Zittel TT Glatzle J Muller M | 2002 | Ann Surg2002，236，2： | 2 |
| 15 | Repairing of goat tibial bone defects with BMP-2 gene-modified tissue-engineered bone显示文摘 | Dai KR Xu XL Tang TT Zhu ZA Yu CF Lou JR Zhang XL | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 16 | Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B显示文摘 | Liaw Y-F Leung NWY Chang TT | | 0，，： | 2 |
| 17 | The time course of changes in mRNA levels in tree shrew sclera during induced myopia and recovery 显示文摘 | Siegwart JT Jr Norton TT | 2002 | Invest Ophthalmol Vis Sci2002，43，7： | 2 |
| 18 | Comparison of limbal and conjunctival autograft transplantation in corneal surface reconstruction in rabbits显示文摘 | Tsai RJF Sun TT Tseng SCG | 1990 | Ophthalmology1990，97，4： | 2 |
| 19 | Apoptosis and caspases after ischemiareperfusion injury in rat retina 显示文摘 | Lam TT Abler AS Tso MM | 1999 | Invest Ophthalmol Vis Sci1999，40，5： | 2 |
| 20 | Partial and Complete Tear of the Anterior Cruciate Ligament显示文摘 | Chen WT Shih TT Tu HY | 2002 | Acta Radiol2002，43，5： | 1 |
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