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| 1 | Command and Control Cities in Global Space-economy Before and after 2008 Geo-economic Transition显示文摘The global economic downturn caused primarily by the US sub-prime mortgage crisis in 2007 engendered revenue loss of the multinational corporations.Existing studies have yet to depict the detrimental impacts on city's command and control functions induced by the sub-prime mortgage crisis together with its residual wave of global economic recession on the global spatial economy.Recent and previous studies have produced an 'instant history' of the global spatial economy before the global economic downturn undermines the global economy in late 2008.However,the waxes and wanes of major cities' command and control functions on the global economic arena before and after the outbreak of financial crisis and its associated geo-economic transitions are still poorly understood.This paper attempts to contribute a new set of customized data to update and fill in the gap in the literature with the investigation of the command and control functions of cities around the world from 2005 to 2009.Particular attentions are paid to the time-space relationship of the geo-economic transition that can capture the recent historical images of the command and control situation of different cities in the world. | Ernest Ka Shing LEE Simon Xiaobin ZHAO Yang XIE | 2012 | Chinese Geographical Science2012，22，3： | 5 |
| 2 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 3 | Long-Term Morbidity and Oncologic Outcomes of Laparoscopic-Assisted Anterior Resection for Upper Rectal Cancer: Ten-Year Results of a Prospective, Randomized Trial显示文摘 | Simon S. M. Ng Ka Lau Leung Janet F. Y. Lee Raymond Y. C. Yiu Jimmy C. M. Li Sophie S. F. Hon | 2009 | Diseases of the Colon & Rectum2009，，： | 2 |
| 4 | 轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗显示文摘王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://gffzz25d7f5dd9bdf4c9eh5wuwqcv6qbuv69bp.ffgz.tsg.suse.edu.cn/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 | 王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 | 2019 | 英国医学杂志中文版2019，22，5： | 2 |
| 5 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 2 |
| 6 | Laparoscopic-Assisted Versus Open Abdominoperineal Resection for Low Rectal Cancer: A Prospective Randomized Trial显示文摘 | Simon S. M. Ng FRCSEd (Gen) Ka Lau Leung MD FRCS (Edin) Janet F. Y. Lee MD FRCSEd (Gen) Raymond Y. C. Yiu FRCSEd (Gen) Jimmy C. M. Li FRACS Anthony Y. B. Teoh MRCS (Edin) Wing Wa Leung MSc | 2008 | Annals of Surgical Oncology2008，，9： | 2 |
| 7 | DNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein显示文摘 | Simon BE Cornell KA Clark TR | 2003 | Infect Immun2003，71，11： | 1 |
| 8 | Liver microsomal parameters relates to oxidative stress and antioxidant systems in hyperthyroid rats subjected to acute lindane treatment显示文摘 | Simon Giavarotti KA Rodrigues L Rodrigues T | 1998 | Free Radic Res1998，29，1： | 1 |
| 9 | ParaceUin-1, a renal tight junction protein required for paracellular Mg2+ resorption显示文摘 | Simon DB Lu Y Choate KA | 1999 | Science1999，285，： | 1 |
| 10 | Stromal proges-terone receptors mediate induction of Indian Hedgehog(IHH)in uterine epithelium and its downstream targetsin uterine Stroma显示文摘 | Simon L Spiewak KA Ekman GC | 2009 | Endocrinol2009，150，8： | 1 |
| 11 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 1 |
| 12 | Laparoscopic-Assisted Versus Open Abdominoperineal Resection for Low Rectal Cancer: A Prospective Randomized Trial显示文摘 | Simon S. M. Ng FRCSEd (Gen) Ka Lau Leung MD FRCS (Edin) Janet F. Y. Lee MD FRCSEd (Gen) Raymond Y. C. Yiu FRCSEd (Gen) Jimmy C. M. Li FRACS Anthony Y. B. Teoh MRCS (Edin) Wing Wa Leung MSc | 2008 | Annals of Surgical Oncology2008，，9： | 1 |
| 13 | Laparoscopic-Assisted Versus Open Abdominoperineal Resection for Low Rectal Cancer: A Prospective Randomized Trial显示文摘 | Simon S. M. Ng Ka Lau Leung Janet F. Y. Lee Raymond Y. C. Yiu Jimmy C. M. Li Anthony Y. B. Teoh Wing Wa Leung | 2008 | Annals of Surgical Oncology2008，，9： | 1 |
| 14 | The use of platelet-rich plasma in arthroscopy and sports medicine:optimizing the healing environment显示文摘 | Lopez-Vidriero E Goulding KA Simon DA | 2010 | Arthroscopy2010，26，： | 1 |
| 15 | Atopic dermatitis in children in the United States, 1997 -2004 : visit trends, patient and provider characteristics ,and prescribing patterns 显示文摘 | Horii KA Simon SD Liu DY | 2007 | Pediatrics2007，120，3： | 1 |
| 16 | Paracellin- 1, a renal tight junction protein required for paracellular Mg2_ resorption显示文摘 | Simon DB Lu Y Choate KA | 1999 | Science1999，285，： | 1 |
| 17 | Psychological issues in craniofacial care: state of the art显示文摘 | Endrigam C Kapp - Simon KA | 1999 | Cleft Palate Cranio:- fau1999，36，1： | 1 |
| 18 | Laparoscopic-assisted versus open total mesorectal excision with anal sphincter preservation for mid and low rectal cancer: a prospective, randomized trial显示文摘 | Simon S. M. Ng Janet F. Y. Lee Raymond Y. C. Yiu Jimmy C. M. Li Sophie S. F. Hon Tony W. C. Mak Dennis K. Y. Ngo Wing Wa Leung Ka Lau Leung | 2014 | Surgical Endoscopy2014，，1： | 1 |
| 19 | Inhibition of Escherichia coli biofilm formation by self assembled monolayers of functional alkanethiols on gold显示文摘 | Hou S Burton EA Simon KA | 2007 | Appl Environ Microbiol2007，73，13： | 1 |
| 20 | Enhancement of lindane - induced liver oxidative stress and hepatotoxicity by thyreid hormone is reduced by gadolinium chloride 显示文摘 | Simon - Giavarotti KA Giavarotti L Comes LF | 2002 | Free Radic Res2002，36，10： | 1 |
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