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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease显示文摘Parkinson's disease is a neurodegenerative disease.Oxidative stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this disease.Physical exercise can regulate oxidative stress.The purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's disease.The aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise program.Our results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's disease.Compared with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session.Our results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme activity.These results could better help understand the target of oxidative stress in Parkinson's disease.This study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK). | Caroline Dani Isabel Teixeira Proenca Jessica Marinho Pamela Peccin Ivy Reichert Vital da Silva Simone Nique Vera Striebel Daniela Pochmann Viviane Rostirola Elsner | 2020 | Neural Regeneration Research2020，15，11： | 4 |
| 3 | Three-dimensional imaging of the uterus:The value of the coronal plane显示文摘Advent in three-dimensional(3D) imaging technology has seen 3D ultrasound establish itself as a useful adjunct complementary to traditional two-dimensional imaging of the female pelvis. This advantage largely arises from its ability to reconstruct the coronal plane of the uterus, which allows further delineation of many gynecological disorders. 3D imaging of the uterus is now the preferred imaging modality for assessing congenital uterine anomalies and intrauterine device localization. Newer indications include the diagnosis of adenomyosis. It can also add invaluable information to delineate other endometrial and myometrial pathology such as fibroids and endometrial polyps. | Lufee Wong Nikki White Jayshree Ramkrishna Edward Araujo Júnior Simon Meagher Fabricio Da Silva Costa | 2015 | World Journal of Radiology2015，7，12： | 3 |
| 4 | Differential effects of CB1and opioid agonists on two populations of adult rat dorsal root ganglion neurons显示文摘 | Khasabova IA Harding-Rose C Simone DA | 2004 | J Neurosci2004，24，7： | 1 |
| 5 | Virtual fluoroscopy: computer- assisted fluoroscopic navigation显示文摘 | Foley KT Simon DA Rampersaud YR | 2010 | Spine2010，26，4： | 1 |
| 6 | Metallothionein is part of a zinc - scavenging mechanism for cell survival under conditions of extreme zinc deprivation显示文摘 | Suhy DA Simon KD Linzer DI | 1999 | J biol Chem1999，274，： | 1 |
| 7 | Metallothionein is part of a zinc scavenging mechanism for cell survival under conditions of extreme zinc deprivation显示文摘 | Suhy DA Simon KD Linzer DI | 1999 | J Biol chem1999，274，14： | 1 |
| 8 | A phase lI trial of gemcitabine/carboplatin with or without trastuzumab in the first- line treatment of patients with metastatic breast cancer显示文摘 | Yardley DA Burris HA 3rd Simons L | 2008 | Clin Breast Cancer2008，8，5： | 1 |
| 9 | Female infertility in mice lacking connexin37 显示文摘 | Simon AM Goodenough DA Li E | 1997 | Nature1997，585，6616： | 1 |
| 10 | Mechanism of can- cer pain显示文摘 | Schmidt BL Hamamoto DT Simone DA | 2010 | Mol Interv2010，10，3： | 1 |
| 11 | Mice lacking connex in40 have cardiac conduction abnormalities characteristic of at rioventricular block and bundle branch block显示文摘 | Simon AM Goodenough DA Paul DL | 1998 | Curr Boil1998，8，5： | 1 |
| 12 | Ethanol and the nervous system显示文摘 | Charness ME Simon RP Greenberg DA | 1989 | N Engl J Med1989，321，7： | 1 |
| 13 | Response properties of mechanoreceptors and nociceptors in mouse glabrous skin:an in vivo study显示文摘 | Cain DM Khasabov SG Simone DA | 2001 | J Neurophysiol2001，85，4： | 1 |
| 14 | p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci显示文摘 | Simone C Forcales SV Hill DA | 2004 | Nat Genet2004，36，7： | 1 |
| 15 | Matrix metalloproteinase gene polymorphisms :lack of association with chronic obstructive pulmonary disease in a Brazilian population 显示文摘 | Schirmer H Basso da Silva L Teixeira P J Moreira J S Moreira A L Simon D | 2009 | Genet Mol Res2009，8，3： | 1 |
| 16 | Virtual fluoroscopyl显示文摘 | FOLEY KT SIMON DA RAMPERSAUD YR | 2001 | Spine2001，26，4： | 1 |
| 17 | The use of platelet-rich plasma in arthroscopy and sports medicine:optimizing the healing environment显示文摘 | Lopez-Vidriero E Goulding KA Simon DA | 2010 | Arthroscopy2010，26，： | 1 |
| 18 | Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons 显示文摘 | Khasabova IA Harding-Rose C Simone DA | 2004 | J Neurosci2004，24，7： | 1 |
| 19 | Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy显示文摘 | Uhelski ML Khasabova IA Simone DA | 2015 | J Neurophysiol2015，113，5： | 1 |
| 20 | Virtual Fluoroscopy for Cervical Spine Surgery显示文摘 | Foley K Rampersaud YR Simone DA | 1999 | Proceedings of the 27th Meeting of the Cervical Spine Research Society Seattle Washington1999，12，： | 1 |
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