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| 1 | Methane production and small intestinal bacterial overgrowth in children living in a slum显示文摘AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests.METHODS:This transversal study included 85 children residing in a slum and 43 children from a private school,all aged between 6 and 10 years,in Osasco,Brazil.For characterization of the groups,data regarding the socioeconomic status and basic housing sanitary conditions were collected.Anthropometric data was obtained in children from both groups.All children completed the hydrogen(H 2) and methane(CH 4) breath test in order to assess small intestinal bacterial overgrowth(SIBO).SIBO was diagnosed when there was an increase in H 2 ≥ 20 ppm or CH 4 ≥ 10 ppm with regard to the fasting value until 60 min after lactulose ingestion.RESULTS:Children from the slum group had worse living conditions and lower nutritional indices than children from the private school.SIBO was found in 30.9%(26/84) of the children from the slum group and in 2.4%(1/41) from the private school group(P = 0.0007).Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school(P = 0.007).A higher concentration of hydrogen in the small intestine(P < 0.001) and in the colon(P < 0.001) was observed among the children from the slum group with SIBO when compared to children from the slum group without SIBO.Methane production was observed in 63.1%(53/84) of the children from the slum group and in 19.5%(8/41) of the children from the private school group(P < 0.0001).Methane production was observed in 38/58(65.5%) of the children without SIBO and in 15/26(57.7%) of the children with SIBO from the slum.Colonic production of hydrogen was lower in methaneproducing children(P = 0.017).CONCLUSION:Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane production.Hydrogen is a substrate for methane production in the colon. | Carolina Santos Mello Soraia Tahan Lígia Cristina FL Melli Mirian Silva do Carmo Rodrigues Ricardo Martin Pereira de Mello Isabel Cristina Affonso Scaletsky Mauro Batista de Morais | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Corporate Social Responsibility and Resource-Based Perspectives显示文摘 | Manuel Castelo Branco Lúcia Lima Rodrigues | 2006 | Journal of Business Ethics2006，，2： | 3 |
| 3 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 4 | Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats 显示文摘 | Gondim F A Rodrigues C L da-Graca J R | 2001 | Auton Neurosci2001，87，1： | 1 |
| 5 | On Rational Resursive Sequences 显示文摘 | Koeie V L Ladas G Rodrigues I W | 1993 | J Math Anal Appl1993，173，： | 1 |
| 6 | Treatment of node-negative infra-centimetric HER2+ invasive breast carcinomas:a joint AERIO/REMAGUS study显示文摘 | Rodrigues MJ Wassermann J Albiges-Sauvin L | 2009 | J Clin Onco12009，27，15： | 1 |
| 7 | Blood pressure response to physical exertion in adolescents: influence of overweight and obesity显示文摘 | Carletti L Rodrigues AN Perez A J | 2008 | Arq Bras Cardiol2008，91，1： | 1 |
| 8 | Normal human monocytes exposed to glioma cells acquire myeloid-derived suppressor cell-like properties显示文摘 | RODRIGUES J C GONZALEZ G C ZHANG L | 2010 | Neuro Oncol2010，12，4： | 1 |
| 9 | lmmunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculo- sis infection and disease显示文摘 | Rodrigues D S Medeiros E A Weckx L Y | 2002 | Clin Exp Immunol2002，128，1： | 1 |
| 10 | A mul- tiobjective modeling approach to locating incinerators 显示文摘 | Alada - Almeida L Coutinho - Rodrigues J Current J | 2009 | Socio -Economic Planning Sciences2009，，2： | 1 |
| 11 | Exploit- ing dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS) for sequential de- termination of trace elements in blood using a dilute- and-shoot procedure显示文摘 | Batista BL Rodrigues JL Nunes JA l | 2009 | Anal Chim Acta2009，639，12： | 1 |
| 12 | Char- acterization of complex networks: a survey of measurements 显示文摘 | COSTA L F RODRIGUES F A TRAVIESO G | 2007 | Advances in Physics2007，56，1： | 1 |
| 13 | Piecewise-affine state feedback for piecewise-affine slab systems using convex optimization 显示文摘 | RODRIGUES L BOYD S | 2005 | Systems and Control Letters2005，，54： | 1 |
| 14 | In vitro reconstitution of an abscisic acid signalling pathway显示文摘 | FUJII H CHINNUSAMY V RODRIGUES A RUBIO S AATONI R PARK S Y CUTLER S R SHEEN J ROTRIGUES P L ZHU J K | 2009 | Nature2009，462，： | 1 |
| 15 | Spatial and temporal variation of phytoplankton in two subtropical Brazilian reservoirs 显示文摘 | BORGES P A F TRAIN S RODRIGUES L C | 2008 | Hydrobiologia2008，607，： | 1 |
| 16 | My- cobacterial heat shock protein 70 induces interleu- kin-10 production: immunomodulation of synovial cell cytokine profile and dendritic cell maturation 显示文摘 | Detanico T Rodrigues L Sabritto AC | 2004 | ClinExp Immunol2004，135，2： | 1 |
| 17 | Novel core (polyester)-shell (polysaccharide) nanoparticles :protein loading and surface modification with leetins显示文摘 | Rodrigues J S Santos-Magalhaes N S Coelho L C B B | 2003 | Journal of Controlled Release2003，92，： | 1 |
| 18 | Novel core (polyester) -shell (polysaccharide) nanoparticles:protein loading and surface modification with lectins显示文摘 | Rodrigues J S Santos-Magalhes N S Coelho L C B B | 2003 | J Controlled Release2003，92，12： | 1 |
| 19 | Global gap analysis:priority regions for expanding the global protected-area network显示文摘 | Rodrigues A S L H R Akcakaya S J Andelman | 2004 | Bio Science2004，54，12： | 1 |
| 20 | Fructooli-gosaccharide production by Penicillium expansum显示文摘 | PRATA M B MUSSATTO S I RODRIGUES L R | 2010 | Biotechnology Letters2010，32，6： | 1 |
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