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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Toward conceptualizing and measuring cognitive structures显示文摘 | Kanwar Rajesh Jerry C Olson and Laura S Sims | 1981 | Advances in Consumer Research1981，8，： | 1 |
| 3 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 4 | Characteristics of basalt fiber as a strengthening material for concrete structures 显示文摘 | Sim J S Park C W Moon D Y | 2005 | Composites Part B2005，，36： | 1 |
| 5 | A parametric formulation of the generalized spectral subtraction method 显示文摘 | Sim B L Tong Y C Chang J S | 1998 | IEEE Trans on Speech and Audio Pro- cessing1998，6，4： | 1 |
| 6 | Influence of dietary energy source on performance and fatty liver syn- drome in White Leghorn laying hens显示文摘 | Bragg D B Sim J S Hodgson G C | 1973 | Poult Sci1973，52，2： | 1 |
| 7 | Anti-solvent co-crystallization of carbamazepine and saccharin显示文摘 | Wang I C Lee M J Sim S J | 2013 | Int J Pharm2013，450，： | 1 |
| 8 | Physicians' knowledge about ionizing radiation and radiological imaging techniques: a cross-sectional survey显示文摘 | Yucel A Alyesil C Sim S | 2011 | Acta Radiol2011，52，5： | 1 |
| 9 | Thermal characterization of Al2O3 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes 显示文摘 | Sim L C Ramanan S R Ismail H | 2005 | Thermochimia Acta2005，430，12： | 1 |
| 10 | A compact lumped-element lowpass filter using low temperature cofired ceramic technology 显示文摘 | Sim S H Kang C Y Choi J W | 2003 | J Eur Ceram Soc2003，23，： | 1 |
| 11 | Orientation characterization and photoconductive properties of ethylenediamine bridged silicon phthalocyanine polymer thin film显示文摘 | SIM J H ONG B S REED C A | 1996 | Thin Solid Films1996，40，2： | 1 |
| 12 | Thermal characterization of Al2O3 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes显示文摘 | SIM L C RAMANAN S R ISMAIL H | 2005 | Thermochimia Acta2005，430，12： | 1 |
| 13 | Thermal characterization of A1203 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes 显示文摘 | Sim L C Ramanan S R Ismail H | 2005 | ThermochimicaActa2005，430，12： | 1 |
| 14 | Determination of pyrazine and flavor variations inpeanutgenotypes during roasting显示文摘 | Baker G L Cornell J A Gorbet D W Okeefe S F Sims C A Talcott ST | 2003 | Journal of Food Science2003，68，1： | 1 |
| 15 | Transferability of cereal EST-SSR markers to ryegrass显示文摘 | Sim S C Yu J K Jo Y K | 2009 | Genome2009，52，5： | 1 |
| 16 | Quantitative detection of DNA by autocatalyticenlargenment of hybridized gold nanoprobes显示文摘 | Zhan Z Cao C Sim S J | | 0，，： | 1 |
| 17 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 18 | Optimising train movements through coast control using genetic algorithms显示文摘 | Chang C S Sim S S | 1997 | IEE Proceedings-Electric Power Application1997，144，1： | 1 |
| 19 | Flavor and oxidative stability of roasted high oleic acid peanuts显示文摘 | Braddock J C Sims C A O'Keefe S K | 1995 | J Food Sci1995，60，3： | 1 |
| 20 | Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice显示文摘 | Cho S Y Sim J S Jeong C S | 2004 | Biol Pharm Bull2004，27，1： | 1 |
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