|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 3 | Macroeconomics and reality 显示文摘 | SIMS C A | 1980 | Econometrica1980，48，5： | 1 |
| 4 | Macroeconomics and Reality显示文摘 | Sims C A | 1980 | Econometrica1980，，48： | 1 |
| 5 | Nonmehing-flesh trait in peaches is not related to low ethylene production rates显示文摘 | Brovelli E A Brecht J K Sherman W B Sims C A | 1999 | HortScience1999，34，： | 1 |
| 6 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 7 | Macroeconomics andreality显示文摘 | SIMS C A | 1980 | Econometrica1980，48，： | 1 |
| 8 | Physicians' knowledge about ionizing radiation and radiological imaging techniques: a cross-sectional survey显示文摘 | Yucel A Alyesil C Sim S | 2011 | Acta Radiol2011，52，5： | 1 |
| 9 | Orientation characterization and photoconductive properties of ethylenediamine bridged silicon phthalocyanine polymer thin film显示文摘 | SIM J H ONG B S REED C A | 1996 | Thin Solid Films1996，40，2： | 1 |
| 10 | Human endometrial CD98 is essential for blastocyst adhesion显示文摘 | Domínguez F Simón C Qui(n)onero A | | 0，，10： | 1 |
| 11 | Comparison of interwar and postwar cycles: Monetarism reconsidered 显示文摘 | Sims C A | 1980 | American Economic Review1980，，70： | 1 |
| 12 | Supercritical carbon dioxide extraction efficiency for carotenes from carrots by RSM显示文摘 | Balaban M O Sims C A | 1996 | Journal of Food Science1996，61，75： | 1 |
| 13 | Money,income and causality显示文摘 | Sims C A | 1972 | American Economic Review1972，62，： | 1 |
| 14 | Airway risk in hospitalized trauma patients with cervical injuries requiring halo fixation显示文摘 | SIMS C A BERGER D L | 2002 | Ann Surg2002，235，2： | 1 |
| 15 | Determination of pyrazine and flavor variations inpeanutgenotypes during roasting显示文摘 | Baker G L Cornell J A Gorbet D W Okeefe S F Sims C A Talcott ST | 2003 | Journal of Food Science2003，68，1： | 1 |
| 16 | A simple model for study of the determination of the price level and the interaction of monetary and fis- cal policy显示文摘 | Sims C A | 1994 | Economic Theory1994，，3： | 1 |
| 17 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 18 | Interpreting the macroeconomic time series facts: The effects of monetary policy显示文摘 | Sims C A | 1992 | European Eco- nomic Review1992，36，5： | 1 |
| 19 | Storage water activity affects flavor fade in high and normal oleic peanuts显示文摘 | Reed K A Sims C A Gorbet D W | 2002 | Food Research Intemational2002，35，： | 1 |
| 20 | Macroeconomics and reality显示文摘 | Sims C A | 1980 | Econometrics1980，48，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员