|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 3 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 4 | Autogenous iliac crest bone graft: complications and functional assessment 显示文摘 | Goulet JA Senunas LE De Silva GL | 1997 | Clin Orthop1997，339，1： | 1 |
| 5 | Hydrotherapy versusconventional land-base显示文摘 | Silva LE Valim V Pessanha AP | 2008 | Physical Therapy2008，88，1： | 1 |
| 6 | Least limiting water range:A potential indicator of changes in near-surface soil physical quality afterthe conversion of Brazilian Savanna into pasture显示文摘 | LEO T P DA SILVA AP MACEDO M C M | 2006 | Soil&Tillage Re-search2006，88，： | 1 |
| 7 | predictive factors for response to Lamivudine in chronic hepatitis B显示文摘 | Da Silva LC da Fonseca LE carrilho FJ | 2000 | Rev Inst Med Trop Sao Paulo2000，42，： | 1 |
| 8 | Phosphorus as an early marker of morbidity and mortality in type 2 chronic kidney disease diabetic patients显示文摘 | Ana Paula Silva André Fragoso Ana Pinho Nelson Tavares Ana Camacho Marília Faísca Pedro Le?o Neves | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 9 | Synthesis of 1,8-cineole and 1,4-cineole by isomerization of α-terpineol catalyzed by heteropoly acid显示文摘 | LE?O LANA E J DA SILVA ROCHA K A KOZHEVNIKOV I V | 2006 | Journal of Molecular Catalysis A:Chemical2006，259，12： | 1 |
| 10 | Effect of rotary or manual instrumentation, with or without a calcium hydroxide 1% chlorhexidlne intracanal dressing,on the healing of experimentally induced chronic periapieal lesions 显示文摘 | ANDIARA DE ROSSI LE'A AB SILVA MARIO R LEOUARDO | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，99，5： | 1 |
| 11 | The role of mossy cell death and activation of protein synthesis in the sprouting of dentate mossy fibers: evidence from calretinin and neo-timm staining in pilocarpine-epileptic mice 显示文摘 | Silva JG Mello LE | 2000 | Epilepsia2000，41，16： | 1 |
| 12 | Progressive load training for the quadriceps muscle associated with proprioception exercises for the prevention of falls in postmenopausal women with osteoporosis:a randomized controlled trial显示文摘 | Teixeira LE Silva KN Imoto AM | 2010 | Osteoporos Int2010，21，4： | 1 |
| 13 | Chemical composition changes in eucalyptus and pinus woods submitted to heat treatment显示文摘 | Brito J O Silva F G Leāo M M | 2008 | Bioresource Technology2008，99，： | 1 |
| 14 | Hydrotherapy versus conven- tional land-based exercise for the management of patients with osteoar- thritis of the knee: a randomized clinical trial 显示文摘 | Silva LE Valim V Pessanha AP | 2008 | Phys Ther Volume2008，88，1： | 1 |
| 15 | Progressive load training for the quadriceps muscle associated with proprioception exercises for the prevention of falls in postmenopausal women with osteoporosis: a randomized controlled trial显示文摘 | Teixeira LE Silva KN Imoto AM | 2010 | Osteoporos Int2010，21，4： | 1 |
| 16 | Radiation therapy and chemotherapy-induced oral mucositis显示文摘 | Volpato LE Silva TC Oliveira TM | 2007 | Braz J Otorhinolaryngol2007，73，4： | 1 |
| 17 | Hydrotherapy versus conventional land-based exercise for the management of patients with osteoarthritis of the knee: a randomized clinical trial显示文摘 | Silva LE Valim V Pessanha AP | 2008 | Phys Ther2008，88，1： | 1 |
| 18 | Efficacy and tolerability of long - term therapy using high lamivudine dose for the treatment of chronic hepatitis B显示文摘 | Da Silva LC Pinho JR Sitnik R Da Fonseca LE Carrilho FJ | 2001 | J Gastroenterol2001，36，7： | 1 |
| 19 | Hydrotherapy versus conventional land-based exercise for the management of patients with osteoarthritis of the knee:a randomized clinical trial显示文摘 | Silva LE Valim V Pessanha AP el al | 2008 | Physical Therapy Volume2008，88，1： | 1 |
| 20 | Control of the estrous cycle in guinea-pig ( Cavia porcellus )显示文摘 | A. Grégoire A. Allard E. Huamán S. León R.M. Silva S. Buff M. Berard T. Joly | 2012 | Theriogenology2012，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员