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您的检索式：作者名="da Fonseca LE"
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| 1 | predictive factors for response to Lamivudine in chronic hepatitis B显示文摘 | Da Silva LC da Fonseca LE carrilho FJ | 2000 | Rev Inst Med Trop Sao Paulo2000，42，： | 1 |
| 2 | Efficacy and tolerability of long - term therapy using high lamivudine dose for the treatment of chronic hepatitis B显示文摘 | Da Silva LC Pinho JR Sitnik R Da Fonseca LE Carrilho FJ | 2001 | J Gastroenterol2001，36，7： | 1 |
| 3 | Predictive factors for respone to lamivudine in chronic hepatitis B显示文摘 | Da Fonseca LE | 2000 | Rev Inst Med Trop San Paulo2000，42，4： | 1 |
| 4 | Multi-omics Analysis of Young Portulaca oleracea L.Plants’Responses to High NaCl Doses Reveals Insights into Pathways and Genes Responsive to Salinity Stress in this Halophyte Species显示文摘Soil salinity is among the abiotic stressors that threaten agriculture the most,and purslane(Portulaca oleracea L.)is a dicot species adapted to inland salt desert and saline habitats that hyper accumulates salt and has high phytoremediation potential.Many researchers consider purslane a suitable model species to study the mechanisms of plant tolerance to drought and salt stresses.Here,a robust salinity stress protocol was developed and used to characterize the morphophysiological responses of young purslane plants to salinity stress;then,leaf tissue underwent characterization by distinct omics platforms to gain further insights into its response to very high salinity stress.The salinity stress protocol did generate different levels of stress by gradients of electrical conductivity at field capacity and water potential in the saturation extract of the substrate,and the morphological parameters indicated three distinct stress levels.As expected from a halophyte species,these plants remained alive under very high levels of salinity stress,showing salt crystal-like structures constituted mainly by Na^(+),Cl^(−),and K^(+)on and around closed stomata.A comprehensive and large-scale metabolome and transcriptome single and integrated analyses were then employed using leaf samples.The multi-omics integration(MOI)system analysis led to a data-set of 51 metabolic pathways with at least one enzyme and one metabolite differentially expressed due to salinity stress.These data sets(of genes and metabolites)are valuable for future studies aimed to deepen our knowledge on the mechanisms behind the high tolerance of this species to salinity stress.In conclusion,besides showing that this species applies salt exclusion already in young plants to support very high levels of salinity stress,the initial analysis of metabolites and transcripts data sets already give some insights into other salt tolerance mechanisms used by this species to support high levels of salinity stress. | Vivianny Nayse Belo Silva Thalliton Luiz Carvalho da Silva Thalita Massaro Malheiros Ferreira Jorge Candido Rodrigues Neto AndréPereira Leão JoséAntônio de Aquino Ribeiro Patrícia Verardi Abdelnur Leonardo Fonseca Valadares Carlos Antônio Ferreira de Sousa Manoel Teixeira Souza Júnior | 2023 | Phenomics2023，3，1： | 0 |
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